A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Shu Chun Chuang; Rachael Stolzenberg-Solomon; Per Magne Ueland; Stein Emil Vollset; Øivind Midttun; Anja Olsen; Anne Tjønneland; Kim Overvad; Marie Christine Boutron-Ruault; Sophie Morois; Franoise Clavel-Chapelon; Birgit Teucher; Rudolf Kaaks; Cornelia Weikert; Heiner Boeing; Antonia Trichopoulou; Vassiliki Benetou; Androniki Naska; Mazda Jenab; Nadia Slimani; Isabelle Romieu; Dominique S. Michaud; Domenico Palli; Sabina Sieri; Salvatore Panico; Carlotta Sacerdote; Rosario Tumino; Guri Skeie; Eric J. Duell; Laudina Rodriguez; Esther Molina-Montes; José María Huerta; Nerea Larrañaga; Aurelio Barricarte Gurrea; Dorthe Johansen; Jonas Manjer; Weimin Ye; Malin Sund; Petra H M Peeters; Suzanne Jeurnink; Nicholas Wareham; Kay Tee Khaw; Francesca Crowe; Elio Riboli; Bas Bueno-De-Mesquita; Paolo Vineis

doi:10.1016/j.ejca.2011.02.007

A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Shu Chun Chuang, Rachael Stolzenberg-Solomon, Per Magne Ueland, Stein Emil Vollset, Øivind Midttun, Anja Olsen, Anne Tjønneland, Kim Overvad, Marie Christine Boutron-Ruault, Sophie Morois, Franoise Clavel-Chapelon, Birgit Teucher, Rudolf Kaaks, Cornelia Weikert, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Androniki Naska, Mazda Jenab, Nadia SlimaniIsabelle Romieu, Dominique S. Michaud, Domenico Palli, Sabina Sieri, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Guri Skeie, Eric J. Duell, Laudina Rodriguez, Esther Molina-Montes, José María Huerta, Nerea Larrañaga, Aurelio Barricarte Gurrea, Dorthe Johansen, Jonas Manjer, Weimin Ye, Malin Sund, Petra H M Peeters, Suzanne Jeurnink, Nicholas Wareham, Kay Tee Khaw, Francesca Crowe, Elio Riboli, Bas Bueno-De-Mesquita, Paolo Vineis

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5′-phosphate, riboflavin, flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a nested case-control study in the EPIC cohort, which has an average of 9.6 years of follow-up (1992-2006), using 463 incident pancreatic cancer cases. Controls were matched to each case by center, sex, age (±1 year), date (±1 year) and time (±3 h) at blood collection and fasting status. Conditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence intervals (CI), adjusting for education, smoking status, plasma cotinine concentration, alcohol drinking, body mass index and diabetes status. We observed a U-shaped association between plasma folate and pancreatic cancer risk. The ORs for plasma folate ≤5, 5-10, 10-15 (reference), 15-20, and >20 nmol/L were 1.58 (95% CI = 0.72-3.46), 1.39 (0.93-2.08), 1.0 (reference), 0.79 (0.52-1.21), and 1.34 (0.89-2.02), respectively. Methionine was associated with an increased risk in men (per quintile increment: OR = 1.17, 95% CI = 1.00-1.38) but not in women (OR = 0.91, 95% CI = 0.78-1.07; p for heterogeneity

Original language	English
Pages (from-to)	1808-1816
Number of pages	9
Journal	European Journal of Cancer
Volume	47
Issue number	12
DOIs	https://doi.org/10.1016/j.ejca.2011.02.007
Publication status	Published - Aug 2011

Keywords

EPIC
Folate
One-carbon metabolism
Pancreatic cancer

ASJC Scopus subject areas

Cancer Research
Oncology

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Chuang, S. C., Stolzenberg-Solomon, R., Ueland, P. M., Vollset, S. E., Midttun, Ø., Olsen, A., Tjønneland, A., Overvad, K., Boutron-Ruault, M. C., Morois, S., Clavel-Chapelon, F., Teucher, B., Kaaks, R., Weikert, C., Boeing, H., Trichopoulou, A., Benetou, V., Naska, A., Jenab, M., ... Vineis, P. (2011). A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. European Journal of Cancer, 47(12), 1808-1816. https://doi.org/10.1016/j.ejca.2011.02.007

A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. / Chuang, Shu Chun; Stolzenberg-Solomon, Rachael; Ueland, Per Magne; Vollset, Stein Emil; Midttun, Øivind; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Boutron-Ruault, Marie Christine; Morois, Sophie; Clavel-Chapelon, Franoise; Teucher, Birgit; Kaaks, Rudolf; Weikert, Cornelia; Boeing, Heiner; Trichopoulou, Antonia; Benetou, Vassiliki; Naska, Androniki; Jenab, Mazda; Slimani, Nadia; Romieu, Isabelle; Michaud, Dominique S.; Palli, Domenico; Sieri, Sabina; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Skeie, Guri; Duell, Eric J.; Rodriguez, Laudina; Molina-Montes, Esther; Huerta, José María; Larrañaga, Nerea; Gurrea, Aurelio Barricarte; Johansen, Dorthe; Manjer, Jonas; Ye, Weimin; Sund, Malin; Peeters, Petra H M; Jeurnink, Suzanne; Wareham, Nicholas; Khaw, Kay Tee; Crowe, Francesca; Riboli, Elio; Bueno-De-Mesquita, Bas; Vineis, Paolo.

In: European Journal of Cancer, Vol. 47, No. 12, 08.2011, p. 1808-1816.

Research output: Contribution to journal › Article › peer-review

Chuang, SC, Stolzenberg-Solomon, R, Ueland, PM, Vollset, SE, Midttun, Ø, Olsen, A, Tjønneland, A, Overvad, K, Boutron-Ruault, MC, Morois, S, Clavel-Chapelon, F, Teucher, B, Kaaks, R, Weikert, C, Boeing, H, Trichopoulou, A, Benetou, V, Naska, A, Jenab, M, Slimani, N, Romieu, I, Michaud, DS, Palli, D, Sieri, S, Panico, S, Sacerdote, C, Tumino, R, Skeie, G, Duell, EJ, Rodriguez, L, Molina-Montes, E, Huerta, JM, Larrañaga, N, Gurrea, AB, Johansen, D, Manjer, J, Ye, W, Sund, M, Peeters, PHM, Jeurnink, S, Wareham, N, Khaw, KT, Crowe, F, Riboli, E, Bueno-De-Mesquita, B & Vineis, P 2011, 'A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition', European Journal of Cancer, vol. 47, no. 12, pp. 1808-1816. https://doi.org/10.1016/j.ejca.2011.02.007

Chuang, Shu Chun ; Stolzenberg-Solomon, Rachael ; Ueland, Per Magne ; Vollset, Stein Emil ; Midttun, Øivind ; Olsen, Anja ; Tjønneland, Anne ; Overvad, Kim ; Boutron-Ruault, Marie Christine ; Morois, Sophie ; Clavel-Chapelon, Franoise ; Teucher, Birgit ; Kaaks, Rudolf ; Weikert, Cornelia ; Boeing, Heiner ; Trichopoulou, Antonia ; Benetou, Vassiliki ; Naska, Androniki ; Jenab, Mazda ; Slimani, Nadia ; Romieu, Isabelle ; Michaud, Dominique S. ; Palli, Domenico ; Sieri, Sabina ; Panico, Salvatore ; Sacerdote, Carlotta ; Tumino, Rosario ; Skeie, Guri ; Duell, Eric J. ; Rodriguez, Laudina ; Molina-Montes, Esther ; Huerta, José María ; Larrañaga, Nerea ; Gurrea, Aurelio Barricarte ; Johansen, Dorthe ; Manjer, Jonas ; Ye, Weimin ; Sund, Malin ; Peeters, Petra H M ; Jeurnink, Suzanne ; Wareham, Nicholas ; Khaw, Kay Tee ; Crowe, Francesca ; Riboli, Elio ; Bueno-De-Mesquita, Bas ; Vineis, Paolo. / A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. In: European Journal of Cancer. 2011 ; Vol. 47, No. 12. pp. 1808-1816.

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abstract = "Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5′-phosphate, riboflavin, flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a nested case-control study in the EPIC cohort, which has an average of 9.6 years of follow-up (1992-2006), using 463 incident pancreatic cancer cases. Controls were matched to each case by center, sex, age (±1 year), date (±1 year) and time (±3 h) at blood collection and fasting status. Conditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence intervals (CI), adjusting for education, smoking status, plasma cotinine concentration, alcohol drinking, body mass index and diabetes status. We observed a U-shaped association between plasma folate and pancreatic cancer risk. The ORs for plasma folate ≤5, 5-10, 10-15 (reference), 15-20, and >20 nmol/L were 1.58 (95% CI = 0.72-3.46), 1.39 (0.93-2.08), 1.0 (reference), 0.79 (0.52-1.21), and 1.34 (0.89-2.02), respectively. Methionine was associated with an increased risk in men (per quintile increment: OR = 1.17, 95% CI = 1.00-1.38) but not in women (OR = 0.91, 95% CI = 0.78-1.07; p for heterogeneity ",

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