TY - JOUR
T1 - A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
AU - Chuang, Shu Chun
AU - Stolzenberg-Solomon, Rachael
AU - Ueland, Per Magne
AU - Vollset, Stein Emil
AU - Midttun, Øivind
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine
AU - Morois, Sophie
AU - Clavel-Chapelon, Franoise
AU - Teucher, Birgit
AU - Kaaks, Rudolf
AU - Weikert, Cornelia
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Benetou, Vassiliki
AU - Naska, Androniki
AU - Jenab, Mazda
AU - Slimani, Nadia
AU - Romieu, Isabelle
AU - Michaud, Dominique S.
AU - Palli, Domenico
AU - Sieri, Sabina
AU - Panico, Salvatore
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Skeie, Guri
AU - Duell, Eric J.
AU - Rodriguez, Laudina
AU - Molina-Montes, Esther
AU - Huerta, José María
AU - Larrañaga, Nerea
AU - Gurrea, Aurelio Barricarte
AU - Johansen, Dorthe
AU - Manjer, Jonas
AU - Ye, Weimin
AU - Sund, Malin
AU - Peeters, Petra H M
AU - Jeurnink, Suzanne
AU - Wareham, Nicholas
AU - Khaw, Kay Tee
AU - Crowe, Francesca
AU - Riboli, Elio
AU - Bueno-De-Mesquita, Bas
AU - Vineis, Paolo
PY - 2011/8
Y1 - 2011/8
N2 - Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5′-phosphate, riboflavin, flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a nested case-control study in the EPIC cohort, which has an average of 9.6 years of follow-up (1992-2006), using 463 incident pancreatic cancer cases. Controls were matched to each case by center, sex, age (±1 year), date (±1 year) and time (±3 h) at blood collection and fasting status. Conditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence intervals (CI), adjusting for education, smoking status, plasma cotinine concentration, alcohol drinking, body mass index and diabetes status. We observed a U-shaped association between plasma folate and pancreatic cancer risk. The ORs for plasma folate ≤5, 5-10, 10-15 (reference), 15-20, and >20 nmol/L were 1.58 (95% CI = 0.72-3.46), 1.39 (0.93-2.08), 1.0 (reference), 0.79 (0.52-1.21), and 1.34 (0.89-2.02), respectively. Methionine was associated with an increased risk in men (per quintile increment: OR = 1.17, 95% CI = 1.00-1.38) but not in women (OR = 0.91, 95% CI = 0.78-1.07; p for heterogeneity
AB - Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5′-phosphate, riboflavin, flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a nested case-control study in the EPIC cohort, which has an average of 9.6 years of follow-up (1992-2006), using 463 incident pancreatic cancer cases. Controls were matched to each case by center, sex, age (±1 year), date (±1 year) and time (±3 h) at blood collection and fasting status. Conditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence intervals (CI), adjusting for education, smoking status, plasma cotinine concentration, alcohol drinking, body mass index and diabetes status. We observed a U-shaped association between plasma folate and pancreatic cancer risk. The ORs for plasma folate ≤5, 5-10, 10-15 (reference), 15-20, and >20 nmol/L were 1.58 (95% CI = 0.72-3.46), 1.39 (0.93-2.08), 1.0 (reference), 0.79 (0.52-1.21), and 1.34 (0.89-2.02), respectively. Methionine was associated with an increased risk in men (per quintile increment: OR = 1.17, 95% CI = 1.00-1.38) but not in women (OR = 0.91, 95% CI = 0.78-1.07; p for heterogeneity
KW - EPIC
KW - Folate
KW - One-carbon metabolism
KW - Pancreatic cancer
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UR - http://www.scopus.com/inward/citedby.url?scp=80051551995&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2011.02.007
DO - 10.1016/j.ejca.2011.02.007
M3 - Article
C2 - 21411310
AN - SCOPUS:80051551995
VL - 47
SP - 1808
EP - 1816
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 12
ER -