A unique case of an indolent myometrial T-Cell lymphoproliferative disorder with phenotypic features resembling uterine CD8+ resident memory T cells

Valentina Tabanelli; Riccardo Valli; Simona Righi; Giuseppe Nucera; Tomás Zecchini Barrese; Stefano Pileri; Elena Sabattini

doi:10.1159/000363346

A unique case of an indolent myometrial T-Cell lymphoproliferative disorder with phenotypic features resembling uterine CD8+ resident memory T cells

Valentina Tabanelli, Riccardo Valli, Simona Righi, Giuseppe Nucera, Tomás Zecchini Barrese, Stefano Pileri, Elena Sabattini

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Indolent extranodal T-cell lymphoproliferative disorders have recently been described as new entities in the gastrointestinal tract and acral sites displaying clonal T-cell receptor (TCR) rearrangement and nonactivated cytotoxic CD8+ T-cell phenotypes.

Methods/Results: We report a unique case of an atypical myometrial T-cell lymphoproliferation in a 39-year-old multiparous woman, which shares many of the features mentioned above: CD8+/TIA1+/granzyme B- phenotype, clonal TCR rearrangement and indolent course.

Conclusion(s): We hypothesize that it might derive from a subset of uterine nonrecirculating CD8+ resident memory T cells expanded after repeated exposure to alloextravillous trophoblastic antigen.

Original language	English
Pages (from-to)	176-182
Number of pages	7
Journal	Pathobiology
Volume	81
Issue number	4
DOIs	https://doi.org/10.1159/000363346
Publication status	Published - Nov 27 2014

Keywords

CD8
Cytotoxic phenotype
T-cell lymphoproliferation
Uterine lesions

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Cell Biology
Medicine(all)

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A unique case of an indolent myometrial T-Cell lymphoproliferative disorder with phenotypic features resembling uterine CD8+ resident memory T cells. / Tabanelli, Valentina; Valli, Riccardo; Righi, Simona; Nucera, Giuseppe; Barrese, Tomás Zecchini; Pileri, Stefano; Sabattini, Elena.

In: Pathobiology, Vol. 81, No. 4, 27.11.2014, p. 176-182.

Research output: Contribution to journal › Article › peer-review

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AU - Nucera, Giuseppe

AU - Barrese, Tomás Zecchini

AU - Pileri, Stefano

AU - Sabattini, Elena

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