A unique case of an indolent myometrial T-Cell lymphoproliferative disorder with phenotypic features resembling uterine CD8+ resident memory T cells

Valentina Tabanelli, Riccardo Valli, Simona Righi, Giuseppe Nucera, Tomás Zecchini Barrese, Stefano Pileri, Elena Sabattini

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Indolent extranodal T-cell lymphoproliferative disorders have recently been described as new entities in the gastrointestinal tract and acral sites displaying clonal T-cell receptor (TCR) rearrangement and nonactivated cytotoxic CD8+ T-cell phenotypes.

Methods/Results: We report a unique case of an atypical myometrial T-cell lymphoproliferation in a 39-year-old multiparous woman, which shares many of the features mentioned above: CD8+/TIA1+/granzyme B- phenotype, clonal TCR rearrangement and indolent course.

Conclusion(s): We hypothesize that it might derive from a subset of uterine nonrecirculating CD8+ resident memory T cells expanded after repeated exposure to alloextravillous trophoblastic antigen.

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalPathobiology
Volume81
Issue number4
DOIs
Publication statusPublished - Nov 27 2014

Keywords

  • CD8
  • Cytotoxic phenotype
  • T-cell lymphoproliferation
  • Uterine lesions

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology
  • Medicine(all)

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