Abstract
Objective: Indolent extranodal T-cell lymphoproliferative disorders have recently been described as new entities in the gastrointestinal tract and acral sites displaying clonal T-cell receptor (TCR) rearrangement and nonactivated cytotoxic CD8+ T-cell phenotypes.
Methods/Results: We report a unique case of an atypical myometrial T-cell lymphoproliferation in a 39-year-old multiparous woman, which shares many of the features mentioned above: CD8+/TIA1+/granzyme B- phenotype, clonal TCR rearrangement and indolent course.
Conclusion(s): We hypothesize that it might derive from a subset of uterine nonrecirculating CD8+ resident memory T cells expanded after repeated exposure to alloextravillous trophoblastic antigen.
| Original language | English |
|---|---|
| Pages (from-to) | 176-182 |
| Number of pages | 7 |
| Journal | Pathobiology |
| Volume | 81 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Nov 27 2014 |
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Keywords
- CD8
- Cytotoxic phenotype
- T-cell lymphoproliferation
- Uterine lesions
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Cell Biology
- Medicine(all)
Cite this
A unique case of an indolent myometrial T-Cell lymphoproliferative disorder with phenotypic features resembling uterine CD8+ resident memory T cells. / Tabanelli, Valentina; Valli, Riccardo; Righi, Simona; Nucera, Giuseppe; Barrese, Tomás Zecchini; Pileri, Stefano; Sabattini, Elena.
In: Pathobiology, Vol. 81, No. 4, 27.11.2014, p. 176-182.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A unique case of an indolent myometrial T-Cell lymphoproliferative disorder with phenotypic features resembling uterine CD8+ resident memory T cells
AU - Tabanelli, Valentina
AU - Valli, Riccardo
AU - Righi, Simona
AU - Nucera, Giuseppe
AU - Barrese, Tomás Zecchini
AU - Pileri, Stefano
AU - Sabattini, Elena
PY - 2014/11/27
Y1 - 2014/11/27
N2 - Objective: Indolent extranodal T-cell lymphoproliferative disorders have recently been described as new entities in the gastrointestinal tract and acral sites displaying clonal T-cell receptor (TCR) rearrangement and nonactivated cytotoxic CD8+ T-cell phenotypes.Methods/Results: We report a unique case of an atypical myometrial T-cell lymphoproliferation in a 39-year-old multiparous woman, which shares many of the features mentioned above: CD8+/TIA1+/granzyme B- phenotype, clonal TCR rearrangement and indolent course.Conclusion(s): We hypothesize that it might derive from a subset of uterine nonrecirculating CD8+ resident memory T cells expanded after repeated exposure to alloextravillous trophoblastic antigen.
AB - Objective: Indolent extranodal T-cell lymphoproliferative disorders have recently been described as new entities in the gastrointestinal tract and acral sites displaying clonal T-cell receptor (TCR) rearrangement and nonactivated cytotoxic CD8+ T-cell phenotypes.Methods/Results: We report a unique case of an atypical myometrial T-cell lymphoproliferation in a 39-year-old multiparous woman, which shares many of the features mentioned above: CD8+/TIA1+/granzyme B- phenotype, clonal TCR rearrangement and indolent course.Conclusion(s): We hypothesize that it might derive from a subset of uterine nonrecirculating CD8+ resident memory T cells expanded after repeated exposure to alloextravillous trophoblastic antigen.
KW - CD8
KW - Cytotoxic phenotype
KW - T-cell lymphoproliferation
KW - Uterine lesions
UR - http://www.scopus.com/inward/record.url?scp=84906001874&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906001874&partnerID=8YFLogxK
U2 - 10.1159/000363346
DO - 10.1159/000363346
M3 - Article
C2 - 25138577
AN - SCOPUS:84906001874
VL - 81
SP - 176
EP - 182
JO - Pathobiology
JF - Pathobiology
SN - 1015-2008
IS - 4
ER -