A unique case of eccrine porocarcinoma with pulmonary lymphangitis and pericardial involvement: Biological characterization and clinical aggressiveness

Edoardo Biondi, Girolamo Ranieri, Antonio Nicolò, Giampietro Gasparini

Research output: Contribution to journalArticle

Abstract

A unique case of eccrine porocarcinoma with pulmonary lymphangitis and pericardial involvement is reported. The clinical course was aggressive, leading to the death of the patient a few months after diagnosis. Certain pathological markers of clinical aggressiveness were retrospectively investigated: p53 and Ki-67 expression were determined by means of immunohistochemistry. Angiogenesis was assessed by determination of intratumor microvessel density at the vascular 'hot spot' with the anti-CD34 monoclonal antibody and quantitative analysis using computerized image analyzer. Both primary tumor and metastatic lymph node presented immunostaining for p53 and Ki-67, with a higher degree of vascularization in the secondary lesions compared to the primary tumor. Our findings suggest a correlation between tumor vascularization and clinicopathological parameters of aggressiveness in malignant eccrine porocarcinoma. Taking into account the disappointing results of current treatments for metastatic eccrine porocarcinoma, the assay of microvessel density may be helpful in selecting the patients of high risk for recurrence or death who may benefit of anti-angiogenic therapies. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalOncology
Volume59
Issue number3
Publication statusPublished - 2000

Fingerprint

Eccrine Porocarcinoma
Lymphangitis
Microvessels
Lung
Neoplasms
Blood Vessels
Biomarkers
Lymph Nodes
Immunohistochemistry
Monoclonal Antibodies
Recurrence
Therapeutics

Keywords

  • Angiogenesis
  • Eccrine porocarcinoma
  • Ki-67
  • p53

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

A unique case of eccrine porocarcinoma with pulmonary lymphangitis and pericardial involvement : Biological characterization and clinical aggressiveness. / Biondi, Edoardo; Ranieri, Girolamo; Nicolò, Antonio; Gasparini, Giampietro.

In: Oncology, Vol. 59, No. 3, 2000, p. 190-195.

Research output: Contribution to journalArticle

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