Panel di ausilio diagnostico nella patologia proliferativa uroteliale: Studio degli Antigeni Citocheratina 20, p53, CD44 e Ki-67

Translated title of the contribution: A useful panel in proliferative urothelial lesions: An analysis of Cytokeratin 20, p53, CD44 and Ki-67 antigens

Serena Russo, G. Botti, P. Vinaccia, C. Iaccarino, S. Maioli, D. Del Prete, F. M. Maiello

Research output: Contribution to journalArticle

Abstract

Urothelium can show several pseudoneoplastic lesions. Mimic lesions diagnosis is therapeutically and prognostically critical but it is often difficult on the basis of morphology alone in bladder biopsy specimen. We studied in a retrospective way an immunohistochemical panel that helps in this differential diagnosis. The panel includes antibodies against cytokeratin 20 (CK20), CD44, Ki67 (MIB-1) e p53 and we applied it to 31 cases of non-neoplastic urothelium (26 urothelial biopsies with reactive atypia and 5 normal urothelium) and 50 cases of urothelial neoplasia where we analized the distribution of the markers over the urothelium. We obtained two different "standard" results, for neoplastic and non-neoplastic urothelium. We were able to prove that this panel is useful, non expensive tool in the differential diagnosis of urothelial proliferative lesions.

Translated title of the contributionA useful panel in proliferative urothelial lesions: An analysis of Cytokeratin 20, p53, CD44 and Ki-67 antigens
Original languageItalian
Pages (from-to)46-49
Number of pages4
JournalPathologica
Volume99
Issue number2
Publication statusPublished - Apr 2007

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Russo, S., Botti, G., Vinaccia, P., Iaccarino, C., Maioli, S., Del Prete, D., & Maiello, F. M. (2007). Panel di ausilio diagnostico nella patologia proliferativa uroteliale: Studio degli Antigeni Citocheratina 20, p53, CD44 e Ki-67. Pathologica, 99(2), 46-49.