A variant in the CD209 promoter is associated with severity of dengue disease

Anavaj Sakuntabhai, Chairat Turbpaiboon, Isabelle Casadémont, Ampaiwan Chuansumrit, Tassanee Lowhnoo, Anna Kajaste-Rudnitski, Sita Mint Kalayanarooj, Kanchana Tangnararatchakit, Nattaya Tangthawornchaikul, Sirijit Vasanawathana, Wathanee Chaiyaratana, Pa Thai Yenchitsomanus, Prapat Suriyaphol, Panisadee Avirutnan, Kulkanya Chokephaibulkit, Fumihiko Matsuda, Sutee Yoksan, Yves Jacob, G. Mark Lathrop, Prida MalasitPhilippe Desprès, Cécile Julier

Research output: Contribution to journalArticle

Abstract

Dengue fever and dengue hemorrhagic fever are mosquitoborne viral diseases. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN1, encoded by CD209), an attachment receptor of dengue virus, is essential for productive infection of dendritic cells. Here, we report strong association between a promoter variant of CD209, DCSIGN1-336, and risk of dengue fever compared with dengue hemorrhagic fever or population controls. The G allele of the variant DCSIGN1-336 was associated with strong protection against dengue fever in three independent cohorts from Thailand, with a carrier frequency of 4.7% in individuals with dengue fever compared with 22.4% in individuals with dengue hemorrhagic fever (odds ratio for risk of dengue hemorrhagic fever versus dengue fever: 5.84, P = 1.4 × 10-7) and 19.5% in controls (odds ratio for protection: 4.90, P = 2 × 10-6). This variant affects an Sp1-like binding site and transcriptional activity in vitro. These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. This may have consequences for therapeutic and preventive strategies.

Original languageEnglish
Pages (from-to)507-513
Number of pages7
JournalNature Genetics
Volume37
Issue number5
DOIs
Publication statusPublished - May 2005

Fingerprint

Dengue
Severe Dengue
Dendritic Cells
Odds Ratio
Population Control
Virus Diseases
Thailand
Alleles
Binding Sites
Infection

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Sakuntabhai, A., Turbpaiboon, C., Casadémont, I., Chuansumrit, A., Lowhnoo, T., Kajaste-Rudnitski, A., ... Julier, C. (2005). A variant in the CD209 promoter is associated with severity of dengue disease. Nature Genetics, 37(5), 507-513. https://doi.org/10.1038/ng1550

A variant in the CD209 promoter is associated with severity of dengue disease. / Sakuntabhai, Anavaj; Turbpaiboon, Chairat; Casadémont, Isabelle; Chuansumrit, Ampaiwan; Lowhnoo, Tassanee; Kajaste-Rudnitski, Anna; Kalayanarooj, Sita Mint; Tangnararatchakit, Kanchana; Tangthawornchaikul, Nattaya; Vasanawathana, Sirijit; Chaiyaratana, Wathanee; Yenchitsomanus, Pa Thai; Suriyaphol, Prapat; Avirutnan, Panisadee; Chokephaibulkit, Kulkanya; Matsuda, Fumihiko; Yoksan, Sutee; Jacob, Yves; Lathrop, G. Mark; Malasit, Prida; Desprès, Philippe; Julier, Cécile.

In: Nature Genetics, Vol. 37, No. 5, 05.2005, p. 507-513.

Research output: Contribution to journalArticle

Sakuntabhai, A, Turbpaiboon, C, Casadémont, I, Chuansumrit, A, Lowhnoo, T, Kajaste-Rudnitski, A, Kalayanarooj, SM, Tangnararatchakit, K, Tangthawornchaikul, N, Vasanawathana, S, Chaiyaratana, W, Yenchitsomanus, PT, Suriyaphol, P, Avirutnan, P, Chokephaibulkit, K, Matsuda, F, Yoksan, S, Jacob, Y, Lathrop, GM, Malasit, P, Desprès, P & Julier, C 2005, 'A variant in the CD209 promoter is associated with severity of dengue disease', Nature Genetics, vol. 37, no. 5, pp. 507-513. https://doi.org/10.1038/ng1550
Sakuntabhai A, Turbpaiboon C, Casadémont I, Chuansumrit A, Lowhnoo T, Kajaste-Rudnitski A et al. A variant in the CD209 promoter is associated with severity of dengue disease. Nature Genetics. 2005 May;37(5):507-513. https://doi.org/10.1038/ng1550
Sakuntabhai, Anavaj ; Turbpaiboon, Chairat ; Casadémont, Isabelle ; Chuansumrit, Ampaiwan ; Lowhnoo, Tassanee ; Kajaste-Rudnitski, Anna ; Kalayanarooj, Sita Mint ; Tangnararatchakit, Kanchana ; Tangthawornchaikul, Nattaya ; Vasanawathana, Sirijit ; Chaiyaratana, Wathanee ; Yenchitsomanus, Pa Thai ; Suriyaphol, Prapat ; Avirutnan, Panisadee ; Chokephaibulkit, Kulkanya ; Matsuda, Fumihiko ; Yoksan, Sutee ; Jacob, Yves ; Lathrop, G. Mark ; Malasit, Prida ; Desprès, Philippe ; Julier, Cécile. / A variant in the CD209 promoter is associated with severity of dengue disease. In: Nature Genetics. 2005 ; Vol. 37, No. 5. pp. 507-513.
@article{2046d697a9c94a68a0430792c9fef086,
title = "A variant in the CD209 promoter is associated with severity of dengue disease",
abstract = "Dengue fever and dengue hemorrhagic fever are mosquitoborne viral diseases. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN1, encoded by CD209), an attachment receptor of dengue virus, is essential for productive infection of dendritic cells. Here, we report strong association between a promoter variant of CD209, DCSIGN1-336, and risk of dengue fever compared with dengue hemorrhagic fever or population controls. The G allele of the variant DCSIGN1-336 was associated with strong protection against dengue fever in three independent cohorts from Thailand, with a carrier frequency of 4.7{\%} in individuals with dengue fever compared with 22.4{\%} in individuals with dengue hemorrhagic fever (odds ratio for risk of dengue hemorrhagic fever versus dengue fever: 5.84, P = 1.4 × 10-7) and 19.5{\%} in controls (odds ratio for protection: 4.90, P = 2 × 10-6). This variant affects an Sp1-like binding site and transcriptional activity in vitro. These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. This may have consequences for therapeutic and preventive strategies.",
author = "Anavaj Sakuntabhai and Chairat Turbpaiboon and Isabelle Casad{\'e}mont and Ampaiwan Chuansumrit and Tassanee Lowhnoo and Anna Kajaste-Rudnitski and Kalayanarooj, {Sita Mint} and Kanchana Tangnararatchakit and Nattaya Tangthawornchaikul and Sirijit Vasanawathana and Wathanee Chaiyaratana and Yenchitsomanus, {Pa Thai} and Prapat Suriyaphol and Panisadee Avirutnan and Kulkanya Chokephaibulkit and Fumihiko Matsuda and Sutee Yoksan and Yves Jacob and Lathrop, {G. Mark} and Prida Malasit and Philippe Despr{\`e}s and C{\'e}cile Julier",
year = "2005",
month = "5",
doi = "10.1038/ng1550",
language = "English",
volume = "37",
pages = "507--513",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - A variant in the CD209 promoter is associated with severity of dengue disease

AU - Sakuntabhai, Anavaj

AU - Turbpaiboon, Chairat

AU - Casadémont, Isabelle

AU - Chuansumrit, Ampaiwan

AU - Lowhnoo, Tassanee

AU - Kajaste-Rudnitski, Anna

AU - Kalayanarooj, Sita Mint

AU - Tangnararatchakit, Kanchana

AU - Tangthawornchaikul, Nattaya

AU - Vasanawathana, Sirijit

AU - Chaiyaratana, Wathanee

AU - Yenchitsomanus, Pa Thai

AU - Suriyaphol, Prapat

AU - Avirutnan, Panisadee

AU - Chokephaibulkit, Kulkanya

AU - Matsuda, Fumihiko

AU - Yoksan, Sutee

AU - Jacob, Yves

AU - Lathrop, G. Mark

AU - Malasit, Prida

AU - Desprès, Philippe

AU - Julier, Cécile

PY - 2005/5

Y1 - 2005/5

N2 - Dengue fever and dengue hemorrhagic fever are mosquitoborne viral diseases. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN1, encoded by CD209), an attachment receptor of dengue virus, is essential for productive infection of dendritic cells. Here, we report strong association between a promoter variant of CD209, DCSIGN1-336, and risk of dengue fever compared with dengue hemorrhagic fever or population controls. The G allele of the variant DCSIGN1-336 was associated with strong protection against dengue fever in three independent cohorts from Thailand, with a carrier frequency of 4.7% in individuals with dengue fever compared with 22.4% in individuals with dengue hemorrhagic fever (odds ratio for risk of dengue hemorrhagic fever versus dengue fever: 5.84, P = 1.4 × 10-7) and 19.5% in controls (odds ratio for protection: 4.90, P = 2 × 10-6). This variant affects an Sp1-like binding site and transcriptional activity in vitro. These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. This may have consequences for therapeutic and preventive strategies.

AB - Dengue fever and dengue hemorrhagic fever are mosquitoborne viral diseases. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN1, encoded by CD209), an attachment receptor of dengue virus, is essential for productive infection of dendritic cells. Here, we report strong association between a promoter variant of CD209, DCSIGN1-336, and risk of dengue fever compared with dengue hemorrhagic fever or population controls. The G allele of the variant DCSIGN1-336 was associated with strong protection against dengue fever in three independent cohorts from Thailand, with a carrier frequency of 4.7% in individuals with dengue fever compared with 22.4% in individuals with dengue hemorrhagic fever (odds ratio for risk of dengue hemorrhagic fever versus dengue fever: 5.84, P = 1.4 × 10-7) and 19.5% in controls (odds ratio for protection: 4.90, P = 2 × 10-6). This variant affects an Sp1-like binding site and transcriptional activity in vitro. These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. This may have consequences for therapeutic and preventive strategies.

UR - http://www.scopus.com/inward/record.url?scp=20944450979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20944450979&partnerID=8YFLogxK

U2 - 10.1038/ng1550

DO - 10.1038/ng1550

M3 - Article

C2 - 15838506

AN - SCOPUS:20944450979

VL - 37

SP - 507

EP - 513

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 5

ER -