A voxel based morphometry study on mild cognitive impairment

C. Pennanen, C. Testa, M. P. Laakso, M. Hallikainen, E. L. Helkala, T. Hänninen, M. Kivipelto, M. Könönen, A. Nissinen, S. Tervo, M. Vanhanen, R. Vanninen, G. B. Frisoni, H. Soininen, S. Tuomainen

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

Background: Mild cognitive impairment (MCI) is the most widely used concept in classifying cognitive impairment in the elderly who do not fulfil the criteria for dementia. MCI is considered to confer an increased risk of progressing to dementia and most often Alzheimer's disease (AD). Various approaches such as imaging of the brain have been applied to predict the conversion of MCI to dementia. A number of volumetric magnetic resonance imaging (MRI) studies have detected atrophy of the medial temporal lobe in subjects with MCI, but for the other cerebral regions the results have been inconsistent. Objective: To study the pattern of brain atrophy in MCI. Methods: Thirty two controls and 51 individuals with MCI deriving from population based cohorts were studied by MRI using voxel based morphometry. The threshold of t maps was set at p

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume76
Issue number1
DOIs
Publication statusPublished - Jan 2005

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Dementia
Atrophy
Magnetic Resonance Imaging
Temporal Lobe
Cognitive Dysfunction
Neuroimaging
Alzheimer Disease
Brain
Population

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Pennanen, C., Testa, C., Laakso, M. P., Hallikainen, M., Helkala, E. L., Hänninen, T., ... Tuomainen, S. (2005). A voxel based morphometry study on mild cognitive impairment. Journal of Neurology, Neurosurgery and Psychiatry, 76(1), 11-14. https://doi.org/10.1136/jnnp.2004.035600

A voxel based morphometry study on mild cognitive impairment. / Pennanen, C.; Testa, C.; Laakso, M. P.; Hallikainen, M.; Helkala, E. L.; Hänninen, T.; Kivipelto, M.; Könönen, M.; Nissinen, A.; Tervo, S.; Vanhanen, M.; Vanninen, R.; Frisoni, G. B.; Soininen, H.; Tuomainen, S.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 76, No. 1, 01.2005, p. 11-14.

Research output: Contribution to journalArticle

Pennanen, C, Testa, C, Laakso, MP, Hallikainen, M, Helkala, EL, Hänninen, T, Kivipelto, M, Könönen, M, Nissinen, A, Tervo, S, Vanhanen, M, Vanninen, R, Frisoni, GB, Soininen, H & Tuomainen, S 2005, 'A voxel based morphometry study on mild cognitive impairment', Journal of Neurology, Neurosurgery and Psychiatry, vol. 76, no. 1, pp. 11-14. https://doi.org/10.1136/jnnp.2004.035600
Pennanen C, Testa C, Laakso MP, Hallikainen M, Helkala EL, Hänninen T et al. A voxel based morphometry study on mild cognitive impairment. Journal of Neurology, Neurosurgery and Psychiatry. 2005 Jan;76(1):11-14. https://doi.org/10.1136/jnnp.2004.035600
Pennanen, C. ; Testa, C. ; Laakso, M. P. ; Hallikainen, M. ; Helkala, E. L. ; Hänninen, T. ; Kivipelto, M. ; Könönen, M. ; Nissinen, A. ; Tervo, S. ; Vanhanen, M. ; Vanninen, R. ; Frisoni, G. B. ; Soininen, H. ; Tuomainen, S. / A voxel based morphometry study on mild cognitive impairment. In: Journal of Neurology, Neurosurgery and Psychiatry. 2005 ; Vol. 76, No. 1. pp. 11-14.
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