A wearable video-oculography based evaluation of saccades and respective clinical correlates in patients with early onset ataxia

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Friedreich Ataxia (FRDA) and other inherited chronic ataxias (CAs) are common causes of early onset ataxias (EOA), a group of conditions still lacking effective therapies and biomarkers. Ocular saccades are considered a reliable paradigm of motor control, useful to track the functioning of underlying neural networks and serving as potential markers for neurological diseases. New Method: A non-invasive video-oculography device (EyeSeeCam) was used to test saccadic parameters (latency, amplitude, duration, velocity) and peak velocity/amplitude ratio (“main sequence”) in pediatric patients with FRDA, CAs and healthy controls, providing correlations with standard clinical scores. Results: Pattern of saccadic features differed between CA and FRDA. The main sequence analysis was impaired respectively in vertical saccades in CA, and in horizontal saccades in FRDA. In CA, the amplitude of vertical saccades was reduced, and the size inversely correlated with the Scale for the assessment and rating of ataxia (SARA) score. In FRDA the amplitude of horizontal saccades directly correlated with SARA score. Comparison with Existing Method: EyeSeeCam allowed testing saccades easily and quickly even in pediatric patients with EOA. Conclusions: The pattern of saccadic impairment differed between FRDA and CAs, resulting a prominent involvement of vertical saccades in CA and of horizontal ones in FRDA, which respectively correlated with SARA score. Since such differences may reflect distinct pathophysiological substrates, saccades emerged as a potential source of biomarkers in EOAs. Availability of handy tools, such as EyeSeeCam, may facilitate future research in this field.

Original languageEnglish
Article number108697
JournalJournal of Neuroscience Methods
Volume338
DOIs
Publication statusPublished - May 15 2020

Keywords

  • Biomarkers
  • Early onset ataxia
  • EyeSeeCam
  • Friedreich ataxia
  • Saccade

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'A wearable video-oculography based evaluation of saccades and respective clinical correlates in patients with early onset ataxia'. Together they form a unique fingerprint.

Cite this