A wide role for NOTCH1 signaling in acute leukemia

Raffaella Chiaramonte; Andrea Basile; Elena Tassi; Elisabetta Calzavara; Valentina Cecchinato; Vincenzo Rossi; Andrea Biondi; Paola Comi

doi:10.1016/j.canlet.2004.07.022

A wide role for NOTCH1 signaling in acute leukemia

Raffaella Chiaramonte, Andrea Basile, Elena Tassi, Elisabetta Calzavara, Valentina Cecchinato, Vincenzo Rossi, Andrea Biondi, Paola Comi

Research output: Contribution to journal › Article › peer-review

Abstract

NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis.

Original language	English
Pages (from-to)	113-120
Number of pages	8
Journal	Cancer Letters
Volume	219
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2004.07.022
Publication status	Published - Feb 28 2005

Keywords

AML
BCP-ALL
JAGGED1
NOTCH1
T-ALL

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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10.1016/j.canlet.2004.07.022

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title = "A wide role for NOTCH1 signaling in acute leukemia",

abstract = "NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis.",

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AU - Chiaramonte, Raffaella

AU - Basile, Andrea

AU - Tassi, Elena

AU - Calzavara, Elisabetta

AU - Cecchinato, Valentina

AU - Rossi, Vincenzo

AU - Biondi, Andrea

AU - Comi, Paola

PY - 2005/2/28

Y1 - 2005/2/28

N2 - NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis.

AB - NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis.

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KW - T-ALL

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A wide role for NOTCH1 signaling in acute leukemia

Abstract

Keywords

ASJC Scopus subject areas

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