A wide role for NOTCH1 signaling in acute leukemia

Raffaella Chiaramonte, Andrea Basile, Elena Tassi, Elisabetta Calzavara, Valentina Cecchinato, Vincenzo Rossi, Andrea Biondi, Paola Comi

Research output: Contribution to journalArticlepeer-review

Abstract

NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis.

Original languageEnglish
Pages (from-to)113-120
Number of pages8
JournalCancer Letters
Volume219
Issue number1
DOIs
Publication statusPublished - Feb 28 2005

Keywords

  • AML
  • BCP-ALL
  • JAGGED1
  • NOTCH1
  • T-ALL

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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