Abstract
NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 113-120 |
| Number of pages | 8 |
| Journal | Cancer Letters |
| Volume | 219 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 28 2005 |
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Keywords
- AML
- BCP-ALL
- JAGGED1
- NOTCH1
- T-ALL
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
Cite this
A wide role for NOTCH1 signaling in acute leukemia. / Chiaramonte, Raffaella; Basile, Andrea; Tassi, Elena; Calzavara, Elisabetta; Cecchinato, Valentina; Rossi, Vincenzo; Biondi, Andrea; Comi, Paola.
In: Cancer Letters, Vol. 219, No. 1, 28.02.2005, p. 113-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A wide role for NOTCH1 signaling in acute leukemia
AU - Chiaramonte, Raffaella
AU - Basile, Andrea
AU - Tassi, Elena
AU - Calzavara, Elisabetta
AU - Cecchinato, Valentina
AU - Rossi, Vincenzo
AU - Biondi, Andrea
AU - Comi, Paola
PY - 2005/2/28
Y1 - 2005/2/28
N2 - NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis.
AB - NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis.
KW - AML
KW - BCP-ALL
KW - JAGGED1
KW - NOTCH1
KW - T-ALL
UR - http://www.scopus.com/inward/record.url?scp=13444266145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13444266145&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2004.07.022
DO - 10.1016/j.canlet.2004.07.022
M3 - Article
C2 - 15694671
AN - SCOPUS:13444266145
VL - 219
SP - 113
EP - 120
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -