A widespread pattern of cortical activations in patients at presentation with clinically isolated symptoms is associated with evolution to definite multiple sclerosis

Maria A. Rocca, Domenico M. Mezzapesa, Angelo Ghezzi, Andrea Falini, Vittorio Martinelli, Giuseppe Scotti, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: Movement-associated cortical changes have been detected at the earlier clinical stage multiple sclerosis. Our purpose was to assess whether different patterns of cortical recruitment are associated with the short-term evolution of definite multiple sclerosis (MS). METHODS: We followed for 1 year a group of patients with clinically isolated syndromes (CISs) suggestive of MS and compared the baseline movement-associated patterns of cortical activations between those patients with and those without evolution to definite MS. RESULTS: Those patients in whom MS did not evolve had more significant activations of several areas part of the "classic" motor network; those who went on to develop MS had more significant activations of several regions in the frontal, parietal, temporal, and occipital lobes. CONCLUSION: hi CIS patients, the extent of early cortical reorganization following tissue injury might be a factor associated with a different disease evolution.

Original languageEnglish
Pages (from-to)1136-1139
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume26
Issue number5
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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