A within-subject analysis of carbamazepine disposition related to development in children with epilepsy

Fiorenzo Albani, Roberto Riva, Manuela Contin, Agostino Baruzzi

Research output: Contribution to journalArticle

Abstract

The effect of aging on carbamazepine (CBZ) plasma level/dose ratio was evaluated retrospectively in 15 children who were receiving CBZ monotherapy and who were followed up for at least 3 years. Subjects of the study were selected from a population of roughly 4,500 patients attending our therapeutic drug monitoring service during a 12-year period. Results showed that the CBZ plasma level/dose ratio increases within subject during childhood, in agreement with data obtained in between-patient studies. However, the increase is not linear with age, the greatest modifications being observed between 9 and 13 years of age. Weight gain alone does not seem to explain this finding, implicating the involvement of complex physiological changes occurring during puberty.

Original languageEnglish
Pages (from-to)457-460
Number of pages4
JournalTherapeutic Drug Monitoring
Volume14
Issue number6
Publication statusPublished - 1992

Keywords

  • Carbamazepine
  • Children
  • Epilepsy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Toxicology

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