Abstract
The effect of aging on carbamazepine (CBZ) plasma level/dose ratio was evaluated retrospectively in 15 children who were receiving CBZ monotherapy and who were followed up for at least 3 years. Subjects of the study were selected from a population of roughly 4,500 patients attending our therapeutic drug monitoring service during a 12-year period. Results showed that the CBZ plasma level/dose ratio increases within subject during childhood, in agreement with data obtained in between-patient studies. However, the increase is not linear with age, the greatest modifications being observed between 9 and 13 years of age. Weight gain alone does not seem to explain this finding, implicating the involvement of complex physiological changes occurring during puberty.
| Original language | English |
|---|---|
| Pages (from-to) | 457-460 |
| Number of pages | 4 |
| Journal | Therapeutic Drug Monitoring |
| Volume | 14 |
| Issue number | 6 |
| Publication status | Published - 1992 |
Keywords
- Carbamazepine
- Children
- Epilepsy
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Health, Toxicology and Mutagenesis
- Public Health, Environmental and Occupational Health
- Toxicology