A Wolf in Sheeps Clothing: A Sporadic Juvenile Polyp of the Colon Harboring an Intramucosal Adenocarcinoma

Alessandro Vanoli, Marco Lucioni, Elena Biletta, Anna Maria Chiaravalli, Costanza Alvisi, Ombretta Luinetti

Research output: Contribution to journalArticle


We describe a solitary peduncolated polypoid lesion with a bilobated head in the transverse colon mucosa of a 51-year-old Caucasian man. Histologically, the lesion was consistent with juvenile polyp (JP), but showing a few dysplastic glands and a focus of intramucosal adenocarcinoma. This finding suggests that, at least in adults, even the sporadic JPs might carry an inherent potential for malignancy, which has so far only been pointed out for syndromic lesions. Additionally, we observed p53 overexpression in both the dysplastic lesions and in the invasive cells but not in the remaining epithelium. We can argue that p53 immunohistochemistry may be helpful in differentiating hyperplastic regenerative atypia of the epithelium, frequently found in JPs, from true dysplasia, a much more rare change in the sporadic JPs.

Original languageEnglish
Pages (from-to)571-574
Number of pages4
JournalInternational Journal of Surgical Pathology
Issue number7
Publication statusPublished - Oct 3 2015



  • dysplasia
  • hamartoma
  • intraepithelial neoplasia
  • juvenile polyp

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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