A WT1 Expressing Metastatic Human Kaposi Sarcoma Xenograft Model

Erzsébet Rásó, Lívia Mészáros, Adriana Albini, József Tímár

Research output: Contribution to journalArticle

Abstract

We have established a non-metastatic and a metastatic human Kaposi sarcoma (KS) xenograft model in SCID mice by injecting KS-Imm cells subcutaneously and intrasplenically, respectively. KS-Imm cells expressed endothelial markers, CD34 and vWF in vivo. Futhermore, we have shown that these cells express all the splice variants of the WT1 gene and WT1wt protein in vitro and in vivo detected by nested PCR and immunohistochemistry. WT1 expression in the peripheral blood was only detectable in case of metastatic KS model suggesting it as a molecular marker of progression.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalPathology and Oncology Research
Volume10
Issue number1
Publication statusPublished - 2004

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Keywords

  • Kaposi sarcoma
  • Metastasis
  • WT1 expression
  • Xenograft model

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

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