A Zenopus multifinger protein, Xfin, is expressed in specialized cell types and is localized in the cytoplasm

Stefania De Lucchini, Filippo M. Rijli, Gennaro Ciliberto, Giuseppina Barsacchi

Research output: Contribution to journalArticlepeer-review

Abstract

Xfin is a member of a large family of Krüppel-type transcripts stored in the Xenopus egg, whose function is unknown. By using polyclonal antibodies raised against fusion proteins containing different portions of Xfin, we have identified the Xfin gene product and established its pattern of expression in some adult tissues and during oogenesis and embryogenesis. The corresponding mRNA localization has been studied by in situ hybridization on ovary and testis sections. The Xfin product is found in the cytoplasm, both during oogenesis and adulthood; in adult tissues, it is differentially expressed in a cell-type specific fashion. The expression of the protein in specialized cell types and its cytoplasmic localization may favour the hypothesis that it could be involved in cell differentiation events through protein-RNA interactions.

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalMechanisms of Development
Volume36
Issue number1-2
DOIs
Publication statusPublished - 1991

Keywords

  • Cell-type specification
  • Spermatogenesis
  • Xenopus development
  • Zn-finger protein

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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