ABC transporters as potential targets for modulation of drug resistance

L. Gatti, G. L. Beretta, G. Cossa, F. Zunino, P. Perego

Research output: Contribution to journalArticlepeer-review


ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.

Original languageEnglish
Pages (from-to)1102-1112
Number of pages11
JournalMini-Reviews in Medicinal Chemistry
Issue number9
Publication statusPublished - 2009


  • Antitumor drugs
  • ATP binding cassette transporters
  • Modulators

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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