ABC transporters as potential targets for modulation of drug resistance

L. Gatti; G. L. Beretta; G. Cossa; F. Zunino; P. Perego

doi:10.2174/138955709788922656

ABC transporters as potential targets for modulation of drug resistance

L. Gatti, G. L. Beretta, G. Cossa, F. Zunino, P. Perego

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.

Original language	English
Pages (from-to)	1102-1112
Number of pages	11
Journal	Mini-Reviews in Medicinal Chemistry
Volume	9
Issue number	9
DOIs	https://doi.org/10.2174/138955709788922656
Publication status	Published - 2009

Keywords

Antitumor drugs
ATP binding cassette transporters
Modulators

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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title = "ABC transporters as potential targets for modulation of drug resistance",

abstract = "ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.",

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author = "L. Gatti and Beretta, {G. L.} and G. Cossa and F. Zunino and P. Perego",

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AU - Beretta, G. L.

AU - Cossa, G.

AU - Zunino, F.

AU - Perego, P.

PY - 2009

Y1 - 2009

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KW - Modulators

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ABC transporters as potential targets for modulation of drug resistance

Abstract

Keywords

ASJC Scopus subject areas

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