ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain

Cyril Broccardo, Vincent Nieoullon, Rada Amin, Frédérique Masmejean, Sonia Carta, Sara Tassi, Matthieu Pophillat, Anna Rubartelli, Michel Pierres, Geneviève Rougon, André Nieoullon, Genèvieve Chazal, Giovanna Chimini

Research output: Contribution to journalArticlepeer-review

Abstract

The notion that the ATP-binding cassette transporter-A2 (ABCA2)q2 may be involved in brain sterol homeostasis and is associated with early onset Alzheimer's disease led us to explore its neural expression. Our data support and extend the previous reports on ABCA2 expression by oligodendrocytes. They evidence that ABCA2 (i) is located in intracellular vesicles, identified in transfected cells as lysosome-related organelles only partially overlapping with classical endolysosomes; (ii) is a marker of neural progenitors as it is expressed in the subventricular zone of the lateral ventricle and the dentate gyrus of the hippocampal formation, sites of continual neurogenesis in the adult brain, and in nestin+ cells differentiated in vitro from embryonic stem cells; (iii) persists, in the adult rodent brain, in a subset of GABAergic and glutamatergic neurons. Considering that the latter are targets of Alzheimer's lesions, these data provide a new rationale to explore the neuropathological consequences of ABCA2 functional dysregulations.

Original languageEnglish
Pages (from-to)345-355
Number of pages11
JournalJournal of Neurochemistry
Volume97
Issue number2
DOIs
Publication statusPublished - Apr 2006

Keywords

  • ATP-binding cassette transporters
  • Embryonic stem cell differentiation
  • Lipids
  • Lysosomes
  • Subventricular zone

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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