Abdominal adiposity and cardiovascular risk factors in adolescents with type 1 diabetes

Giuliana Valerio, Dario Iafusco, Stefano Zucchini, Claudio Maffeis, R. Lera, V. Cherubini, M. Biagioni, A. Rollo, F. Gallo, S. Toni, M. Guasti, F. Mammí, M. Bruzzese, F. Lombardo, G. Salzano, A. Scaramuzza, G. V. Zuccotti, L. Iughetti, B. Predieri, V. CalcaterraG. Federico, B. Marchi, F. Cerutti, I. Rabbone, G. Cardinale, F. De Berardinis, V. De Donno, A. Franzese, E. Mozzillo, F. Prisco, M. A. Zedda, C. Ripoli

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To analyze the prevalence of abdominal adiposity and other traditional risk factors for cardiovascular disease in a large sample of Italian adolescents with type 1 diabetes mellitus (T1DM). Methods: T1DM adolescents (n=412 age: 17.3 ± 0.9. years) were enrolled from 18 clinical centres. Anthropometric and laboratory parameters, blood pressure and data on insulin treatment were registered. Metabolic syndrome (MetSy) was defined according to the International Diabetes Federation criteria. Results: Abdominal obesity was the most common risk factor (20.1%) in females, while hypertension in males (25.1%). MetSy was found in 9.5% patients, predominantly in females. Patients with MetSy exhibited higher insulin requirement per body surface area and higher glycated hemoglobin than patients without MetSy. Overweight/obese patients had a much higher prevalence of MetSy than normal weight patients. The logistic regression analysis showed that just waist-to-height ratio and insulin dose per body surface area contributed to discriminate subjects with the MetSy from those without. Conclusion: Adolescence is a critical period in determining risk of future vascular complications in T1DM. Pediatric diabetologists need to be aware of the considerable occurrence of abdominal adiposity and MetSy in T1DM patients, particularly in females, and should make any effort to achieve normal weight and better health outcomes.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume97
Issue number1
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Abdominal obesity
  • Cardiovascular risk
  • Metabolic syndrome
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

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