Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort

Sabrina Schlesinger, Krasimira Aleksandrova, Tobias Pischon, Veronika Fedirko, Mazda Jenab, Elisabeth Trepo, Paolo Boffetta, Christina C. Dahm, Kim Overvad, Anne Tjønneland, Jytte Halkjær, Guy Fagherazzi, Marie Christine Boutron-Ruault, Franck Carbonnel, Rudolf Kaaks, Annekatrin Lukanova, Heiner Boeing, Antonia Trichopoulou, Christina Bamia, Pagona LagiouDomenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Paolo Vineis, Bueno De Mesquita Hb, Saskia Van Den Berg, Petra H M Peeters, Tonje Braaten, Elisabete Weiderpass, J. Ramón Quirós, Noémie Travier, María José Sánchez, Carmen Navarro, Aurelio Barricarte, Miren Dorronsoro, Björn Lindkvist, Sara Regner, Mårten Werner, Malin Sund, Kay Tee Khaw, Nicholas Wareham, Ruth C. Travis, Teresa Norat, Petra A. Wark, Elio Riboli, Ute Nöthlings

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested case-control subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.09-5.87; ptrend <0.0001] and with GBC (RR: 1.56, 95% CI: 1.12-2.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.49-4.13;

Original languageEnglish
Pages (from-to)645-657
Number of pages13
JournalInternational Journal of Cancer
Volume132
Issue number3
DOIs
Publication statusPublished - Feb 1 2013

Fingerprint

Biliary Tract Neoplasms
Abdominal Obesity
Weight Gain
Gallbladder Neoplasms
Hepatocellular Carcinoma
Liver
Confidence Intervals
Hip
Bile Duct Neoplasms
Intrahepatic Bile Ducts
Extrahepatic Bile Ducts
Weights and Measures
Waist Circumference
Liver Neoplasms
Proportional Hazards Models
Hepatitis B virus
Hepacivirus
Body Mass Index
Obesity
Waist-Height Ratio

Keywords

  • abdominal fat
  • biliary tract neoplasms
  • hepatocellular carcinoma
  • liver neoplasms
  • obesity
  • weight change

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Schlesinger, S., Aleksandrova, K., Pischon, T., Fedirko, V., Jenab, M., Trepo, E., ... Nöthlings, U. (2013). Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort. International Journal of Cancer, 132(3), 645-657. https://doi.org/10.1002/ijc.27645

Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort. / Schlesinger, Sabrina; Aleksandrova, Krasimira; Pischon, Tobias; Fedirko, Veronika; Jenab, Mazda; Trepo, Elisabeth; Boffetta, Paolo; Dahm, Christina C.; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Fagherazzi, Guy; Boutron-Ruault, Marie Christine; Carbonnel, Franck; Kaaks, Rudolf; Lukanova, Annekatrin; Boeing, Heiner; Trichopoulou, Antonia; Bamia, Christina; Lagiou, Pagona; Palli, Domenico; Grioni, Sara; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Hb, Bueno De Mesquita; Van Den Berg, Saskia; Peeters, Petra H M; Braaten, Tonje; Weiderpass, Elisabete; Quirós, J. Ramón; Travier, Noémie; Sánchez, María José; Navarro, Carmen; Barricarte, Aurelio; Dorronsoro, Miren; Lindkvist, Björn; Regner, Sara; Werner, Mårten; Sund, Malin; Khaw, Kay Tee; Wareham, Nicholas; Travis, Ruth C.; Norat, Teresa; Wark, Petra A.; Riboli, Elio; Nöthlings, Ute.

In: International Journal of Cancer, Vol. 132, No. 3, 01.02.2013, p. 645-657.

Research output: Contribution to journalArticle

Schlesinger, S, Aleksandrova, K, Pischon, T, Fedirko, V, Jenab, M, Trepo, E, Boffetta, P, Dahm, CC, Overvad, K, Tjønneland, A, Halkjær, J, Fagherazzi, G, Boutron-Ruault, MC, Carbonnel, F, Kaaks, R, Lukanova, A, Boeing, H, Trichopoulou, A, Bamia, C, Lagiou, P, Palli, D, Grioni, S, Panico, S, Tumino, R, Vineis, P, Hb, BDM, Van Den Berg, S, Peeters, PHM, Braaten, T, Weiderpass, E, Quirós, JR, Travier, N, Sánchez, MJ, Navarro, C, Barricarte, A, Dorronsoro, M, Lindkvist, B, Regner, S, Werner, M, Sund, M, Khaw, KT, Wareham, N, Travis, RC, Norat, T, Wark, PA, Riboli, E & Nöthlings, U 2013, 'Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort', International Journal of Cancer, vol. 132, no. 3, pp. 645-657. https://doi.org/10.1002/ijc.27645
Schlesinger, Sabrina ; Aleksandrova, Krasimira ; Pischon, Tobias ; Fedirko, Veronika ; Jenab, Mazda ; Trepo, Elisabeth ; Boffetta, Paolo ; Dahm, Christina C. ; Overvad, Kim ; Tjønneland, Anne ; Halkjær, Jytte ; Fagherazzi, Guy ; Boutron-Ruault, Marie Christine ; Carbonnel, Franck ; Kaaks, Rudolf ; Lukanova, Annekatrin ; Boeing, Heiner ; Trichopoulou, Antonia ; Bamia, Christina ; Lagiou, Pagona ; Palli, Domenico ; Grioni, Sara ; Panico, Salvatore ; Tumino, Rosario ; Vineis, Paolo ; Hb, Bueno De Mesquita ; Van Den Berg, Saskia ; Peeters, Petra H M ; Braaten, Tonje ; Weiderpass, Elisabete ; Quirós, J. Ramón ; Travier, Noémie ; Sánchez, María José ; Navarro, Carmen ; Barricarte, Aurelio ; Dorronsoro, Miren ; Lindkvist, Björn ; Regner, Sara ; Werner, Mårten ; Sund, Malin ; Khaw, Kay Tee ; Wareham, Nicholas ; Travis, Ruth C. ; Norat, Teresa ; Wark, Petra A. ; Riboli, Elio ; Nöthlings, Ute. / Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort. In: International Journal of Cancer. 2013 ; Vol. 132, No. 3. pp. 645-657.
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AU - Trepo, Elisabeth

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