Abdominal thromboses of splanchnic, renal and ovarian veins

Valerio De Stefano, Ida Martinelli

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Thromboses of abdominal veins outside the iliac-caval axis are rare but clinically relevant. Early deaths after splanchnic vein thrombosis occur in 5-30% of cases. Sequelae can be liver failure or bowel infarction after splanchnic vein thrombosis, renal insufficiency after renal vein thrombosis, ovarian infarction after ovarian vein thrombosis. Local cancer or infections are rare in Budd-Chiari syndrome, and common for other sites. Inherited thrombophilia is detected in 30-50% of patients. Myeloproliferative neoplasms are the main cause of splanchnic vein thrombosis: 20-50% of patients have an overt myeloproliferative neoplasm and/or carry the molecular marker JAK2 V617F. Renal vein thrombosis is closely related to nephrotic syndrome; finally, ovarian vein thrombosis can complicate puerperium. Heparin is used for acute treatment, sometimes in conjunction with systemic or local thrombolysis. Vitamin K-antagonists are recommended for 3-6 months, and long-term in patients with Budd-Chiari syndrome, unprovoked splanchnic vein thrombosis, or renal vein thrombosis with a permanent prothrombotic state such as nephrotic syndrome.

Original languageEnglish
Pages (from-to)253-264
Number of pages12
JournalBest Practice and Research: Clinical Haematology
Volume25
Issue number3
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Renal Veins
Viscera
Vitamin K
Liver
Heparin
Thrombosis
Veins
Budd-Chiari Syndrome
Nephrotic Syndrome
Infarction
Iliac Vein
Neoplasms
Venae Cavae
Thrombophilia
Liver Failure
Postpartum Period
Renal Insufficiency

Keywords

  • Budd-Chiari syndrome
  • extrahepatic portal vein thrombosis
  • mesenteric vein thrombosis
  • ovarian vein thrombosis
  • renal vein thrombosis

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry

Cite this

Abdominal thromboses of splanchnic, renal and ovarian veins. / De Stefano, Valerio; Martinelli, Ida.

In: Best Practice and Research: Clinical Haematology, Vol. 25, No. 3, 09.2012, p. 253-264.

Research output: Contribution to journalArticle

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