Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants

Joe Poglian; Jian Ming Dong; Peter De Wulf; Dierdre Furlong; Dana Boyd; Richard Losick; Kit Pogliano; E. C C Lin

Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants

Joe Poglian, Jian Ming Dong, Peter De Wulf, Dierdre Furlong, Dana Boyd, Richard Losick, Kit Pogliano, E. C C Lin

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location os FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on Cpxr or extend their signalling activity to one or more noncognate response regulators involved in cell division.

Original language	English
Pages (from-to)	3486-3490
Number of pages	5
Journal	Journal of Bacteriology
Volume	180
Issue number	13
Publication status	Published - Jul 1998

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Immunology

Cite this

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title = "Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants",

abstract = "In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location os FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on Cpxr or extend their signalling activity to one or more noncognate response regulators involved in cell division.",

author = "Joe Poglian and Dong, {Jian Ming} and {De Wulf}, Peter and Dierdre Furlong and Dana Boyd and Richard Losick and Kit Pogliano and Lin, {E. C C}",

year = "1998",

month = jul,

language = "English",

volume = "180",

pages = "3486--3490",

journal = "Journal of Bacteriology",

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T1 - Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants

AU - Poglian, Joe

AU - Dong, Jian Ming

AU - De Wulf, Peter

AU - Furlong, Dierdre

AU - Boyd, Dana

AU - Losick, Richard

AU - Pogliano, Kit

AU - Lin, E. C C

PY - 1998/7

Y1 - 1998/7

N2 - In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location os FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on Cpxr or extend their signalling activity to one or more noncognate response regulators involved in cell division.

AB - In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location os FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on Cpxr or extend their signalling activity to one or more noncognate response regulators involved in cell division.

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JO - Journal of Bacteriology

JF - Journal of Bacteriology

SN - 0021-9193

IS - 13

ER -

Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants

Abstract

ASJC Scopus subject areas

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