Abstract
In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location os FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on Cpxr or extend their signalling activity to one or more noncognate response regulators involved in cell division.
| Original language | English |
|---|---|
| Pages (from-to) | 3486-3490 |
| Number of pages | 5 |
| Journal | Journal of Bacteriology |
| Volume | 180 |
| Issue number | 13 |
| Publication status | Published - Jul 1998 |
Fingerprint
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Immunology
Cite this
Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants. / Poglian, Joe; Dong, Jian Ming; De Wulf, Peter; Furlong, Dierdre; Boyd, Dana; Losick, Richard; Pogliano, Kit; Lin, E. C C.
In: Journal of Bacteriology, Vol. 180, No. 13, 07.1998, p. 3486-3490.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants
AU - Poglian, Joe
AU - Dong, Jian Ming
AU - De Wulf, Peter
AU - Furlong, Dierdre
AU - Boyd, Dana
AU - Losick, Richard
AU - Pogliano, Kit
AU - Lin, E. C C
PY - 1998/7
Y1 - 1998/7
N2 - In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location os FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on Cpxr or extend their signalling activity to one or more noncognate response regulators involved in cell division.
AB - In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location os FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on Cpxr or extend their signalling activity to one or more noncognate response regulators involved in cell division.
UR - http://www.scopus.com/inward/record.url?scp=0031802099&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031802099&partnerID=8YFLogxK
M3 - Article
C2 - 9642209
AN - SCOPUS:0031802099
VL - 180
SP - 3486
EP - 3490
JO - Journal of Bacteriology
JF - Journal of Bacteriology
SN - 0021-9193
IS - 13
ER -