Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants

Joe Poglian, Jian Ming Dong, Peter De Wulf, Dierdre Furlong, Dana Boyd, Richard Losick, Kit Pogliano, E. C C Lin

Research output: Contribution to journalArticle

Abstract

In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location os FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on Cpxr or extend their signalling activity to one or more noncognate response regulators involved in cell division.

Original languageEnglish
Pages (from-to)3486-3490
Number of pages5
JournalJournal of Bacteriology
Volume180
Issue number13
Publication statusPublished - Jul 1998

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Cell Division
Phosphotransferases
Escherichia coli
Operon
Signal Transduction
Mutation
Genes

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Poglian, J., Dong, J. M., De Wulf, P., Furlong, D., Boyd, D., Losick, R., ... Lin, E. C. C. (1998). Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants. Journal of Bacteriology, 180(13), 3486-3490.

Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants. / Poglian, Joe; Dong, Jian Ming; De Wulf, Peter; Furlong, Dierdre; Boyd, Dana; Losick, Richard; Pogliano, Kit; Lin, E. C C.

In: Journal of Bacteriology, Vol. 180, No. 13, 07.1998, p. 3486-3490.

Research output: Contribution to journalArticle

Poglian, J, Dong, JM, De Wulf, P, Furlong, D, Boyd, D, Losick, R, Pogliano, K & Lin, ECC 1998, 'Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants', Journal of Bacteriology, vol. 180, no. 13, pp. 3486-3490.
Poglian J, Dong JM, De Wulf P, Furlong D, Boyd D, Losick R et al. Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants. Journal of Bacteriology. 1998 Jul;180(13):3486-3490.
Poglian, Joe ; Dong, Jian Ming ; De Wulf, Peter ; Furlong, Dierdre ; Boyd, Dana ; Losick, Richard ; Pogliano, Kit ; Lin, E. C C. / Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants. In: Journal of Bacteriology. 1998 ; Vol. 180, No. 13. pp. 3486-3490.
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