In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location os FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on Cpxr or extend their signalling activity to one or more noncognate response regulators involved in cell division.
|Number of pages||5|
|Journal||Journal of Bacteriology|
|Publication status||Published - Jul 1998|
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology