ABERRANT EXPRESSION OF HLA-DR ANTIGEN ON THYROCYTES IN GRAVES' DISEASE: RELEVANCE FOR AUTOIMMUNITY

T. Hanafusa, L. Chiovato, Deborah Doniach, R. Pujol-Borrell, R. C G Russell, G. F. Bottazzo

Research output: Contribution to journalArticle

Abstract

To investigate the expression of class II histocompatibility antigens HLA-DR in the thyrocytes in autoimmune thyroid diseases, 47 thyroidectomy specimens were examined by immunofluorescence with monoclonal antibodies to the non-polymorphic region of the DR molecule. Aberrant DR expression was most marked in the Hashimoto gland, with the entire section being strongly stained. DR expression was seen in discrete groups of follicles in 20/26 thyroids from patients with Graves' disease, in 2/9 non-toxic nodular goitres, and in none of 11 specimens of "normal" thyroid. The presence of lymphoid foci, "activated" T-cells, and immune complexes on the follicular basement membrane were not regularly associated with the DR-positive thyroid acini. HLA-A,B,C expression was also increased in the diseased glands. Expression of HLA-DR thus seems to be one of the earliest manifestations of autoimmune lymphocytic thyroiditis.

Original languageEnglish
Pages (from-to)1111-1115
Number of pages5
JournalLancet
Volume322
Issue number8359
DOIs
Publication statusPublished - Nov 12 1983

ASJC Scopus subject areas

  • Medicine(all)

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    Hanafusa, T., Chiovato, L., Doniach, D., Pujol-Borrell, R., Russell, R. C. G., & Bottazzo, G. F. (1983). ABERRANT EXPRESSION OF HLA-DR ANTIGEN ON THYROCYTES IN GRAVES' DISEASE: RELEVANCE FOR AUTOIMMUNITY. Lancet, 322(8359), 1111-1115. https://doi.org/10.1016/S0140-6736(83)90628-1