TY - JOUR
T1 - Aberrant FHIT transcripts in Merkel cell carcinoma
AU - Sozzi, Gabriella
AU - Alder, Hansjuerg
AU - Tornielli, Silvana
AU - Corletto, Valentina
AU - Baffa, Raffaele
AU - Veronese, Maria Luisa
AU - Negrini, Massimo
AU - Pilotti, Silvana
AU - Pierotti, Marco A.
AU - Huebner, Kay
AU - Croce, Carlo Maria
PY - 1996/6/1
Y1 - 1996/6/1
N2 - Merkel cell carcinoma is a rare neuroendocrine carcinoma of the skin which shares several features with small cell lung carcinoma. In a previous study, we reported a high frequency of abnormalities of the FHIT gene, located at 3p14.2, in small cell lung tumors. To determine the role of the FHIT gene in small cell neuroendocrine malignancies, 14 cases of Merkel cell carcinoma were analyzed by reverse transcription of FHIT mRNA followed by PCR amplification and sequencing of products. Eight of 14 tumors (57%) displayed abnormal FHIT products that lacked three or more exons of the FHIT gene. The pattern of abnormal transcripts was similar to that observed in small cell lung tumors, suggesting that FHIT abnormalities might be a common genetic marker of these two types of neuroendocrine tumors.
AB - Merkel cell carcinoma is a rare neuroendocrine carcinoma of the skin which shares several features with small cell lung carcinoma. In a previous study, we reported a high frequency of abnormalities of the FHIT gene, located at 3p14.2, in small cell lung tumors. To determine the role of the FHIT gene in small cell neuroendocrine malignancies, 14 cases of Merkel cell carcinoma were analyzed by reverse transcription of FHIT mRNA followed by PCR amplification and sequencing of products. Eight of 14 tumors (57%) displayed abnormal FHIT products that lacked three or more exons of the FHIT gene. The pattern of abnormal transcripts was similar to that observed in small cell lung tumors, suggesting that FHIT abnormalities might be a common genetic marker of these two types of neuroendocrine tumors.
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M3 - Article
C2 - 8653678
AN - SCOPUS:9344225158
VL - 56
SP - 2472
EP - 2474
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 11
ER -