Aberrant FHIT transcripts in Merkel cell carcinoma

Gabriella Sozzi, Hansjuerg Alder, Silvana Tornielli, Valentina Corletto, Raffaele Baffa, Maria Luisa Veronese, Massimo Negrini, Silvana Pilotti, Marco A. Pierotti, Kay Huebner, Carlo Maria Croce

Research output: Contribution to journalArticlepeer-review

Abstract

Merkel cell carcinoma is a rare neuroendocrine carcinoma of the skin which shares several features with small cell lung carcinoma. In a previous study, we reported a high frequency of abnormalities of the FHIT gene, located at 3p14.2, in small cell lung tumors. To determine the role of the FHIT gene in small cell neuroendocrine malignancies, 14 cases of Merkel cell carcinoma were analyzed by reverse transcription of FHIT mRNA followed by PCR amplification and sequencing of products. Eight of 14 tumors (57%) displayed abnormal FHIT products that lacked three or more exons of the FHIT gene. The pattern of abnormal transcripts was similar to that observed in small cell lung tumors, suggesting that FHIT abnormalities might be a common genetic marker of these two types of neuroendocrine tumors.

Original languageEnglish
Pages (from-to)2472-2474
Number of pages3
JournalCancer Research
Volume56
Issue number11
Publication statusPublished - Jun 1 1996

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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