Aberrant FHIT transcripts in Merkel cell carcinoma

Gabriella Sozzi; Hansjuerg Alder; Silvana Tornielli; Valentina Corletto; Raffaele Baffa; Maria Luisa Veronese; Massimo Negrini; Silvana Pilotti; Marco A. Pierotti; Kay Huebner; Carlo Maria Croce

Aberrant FHIT transcripts in Merkel cell carcinoma

Gabriella Sozzi, Hansjuerg Alder, Silvana Tornielli, Valentina Corletto, Raffaele Baffa, Maria Luisa Veronese, Massimo Negrini, Silvana Pilotti, Marco A. Pierotti, Kay Huebner, Carlo Maria Croce

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Merkel cell carcinoma is a rare neuroendocrine carcinoma of the skin which shares several features with small cell lung carcinoma. In a previous study, we reported a high frequency of abnormalities of the FHIT gene, located at 3p14.2, in small cell lung tumors. To determine the role of the FHIT gene in small cell neuroendocrine malignancies, 14 cases of Merkel cell carcinoma were analyzed by reverse transcription of FHIT mRNA followed by PCR amplification and sequencing of products. Eight of 14 tumors (57%) displayed abnormal FHIT products that lacked three or more exons of the FHIT gene. The pattern of abnormal transcripts was similar to that observed in small cell lung tumors, suggesting that FHIT abnormalities might be a common genetic marker of these two types of neuroendocrine tumors.

Original language	English
Pages (from-to)	2472-2474
Number of pages	3
Journal	Cancer Research
Volume	56
Issue number	11
Publication status	Published - Jun 1 1996

ASJC Scopus subject areas

Cancer Research
Oncology

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Aberrant FHIT transcripts in Merkel cell carcinoma. / Sozzi, Gabriella; Alder, Hansjuerg; Tornielli, Silvana; Corletto, Valentina; Baffa, Raffaele; Veronese, Maria Luisa; Negrini, Massimo; Pilotti, Silvana; Pierotti, Marco A.; Huebner, Kay; Croce, Carlo Maria.

In: Cancer Research, Vol. 56, No. 11, 01.06.1996, p. 2472-2474.

Research output: Contribution to journal › Article › peer-review

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title = "Aberrant FHIT transcripts in Merkel cell carcinoma",

abstract = "Merkel cell carcinoma is a rare neuroendocrine carcinoma of the skin which shares several features with small cell lung carcinoma. In a previous study, we reported a high frequency of abnormalities of the FHIT gene, located at 3p14.2, in small cell lung tumors. To determine the role of the FHIT gene in small cell neuroendocrine malignancies, 14 cases of Merkel cell carcinoma were analyzed by reverse transcription of FHIT mRNA followed by PCR amplification and sequencing of products. Eight of 14 tumors (57%) displayed abnormal FHIT products that lacked three or more exons of the FHIT gene. The pattern of abnormal transcripts was similar to that observed in small cell lung tumors, suggesting that FHIT abnormalities might be a common genetic marker of these two types of neuroendocrine tumors.",

author = "Gabriella Sozzi and Hansjuerg Alder and Silvana Tornielli and Valentina Corletto and Raffaele Baffa and Veronese, {Maria Luisa} and Massimo Negrini and Silvana Pilotti and Pierotti, {Marco A.} and Kay Huebner and Croce, {Carlo Maria}",

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AU - Sozzi, Gabriella

AU - Alder, Hansjuerg

AU - Tornielli, Silvana

AU - Corletto, Valentina

AU - Baffa, Raffaele

AU - Veronese, Maria Luisa

AU - Negrini, Massimo

AU - Pilotti, Silvana

AU - Pierotti, Marco A.

AU - Huebner, Kay

AU - Croce, Carlo Maria

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N2 - Merkel cell carcinoma is a rare neuroendocrine carcinoma of the skin which shares several features with small cell lung carcinoma. In a previous study, we reported a high frequency of abnormalities of the FHIT gene, located at 3p14.2, in small cell lung tumors. To determine the role of the FHIT gene in small cell neuroendocrine malignancies, 14 cases of Merkel cell carcinoma were analyzed by reverse transcription of FHIT mRNA followed by PCR amplification and sequencing of products. Eight of 14 tumors (57%) displayed abnormal FHIT products that lacked three or more exons of the FHIT gene. The pattern of abnormal transcripts was similar to that observed in small cell lung tumors, suggesting that FHIT abnormalities might be a common genetic marker of these two types of neuroendocrine tumors.

AB - Merkel cell carcinoma is a rare neuroendocrine carcinoma of the skin which shares several features with small cell lung carcinoma. In a previous study, we reported a high frequency of abnormalities of the FHIT gene, located at 3p14.2, in small cell lung tumors. To determine the role of the FHIT gene in small cell neuroendocrine malignancies, 14 cases of Merkel cell carcinoma were analyzed by reverse transcription of FHIT mRNA followed by PCR amplification and sequencing of products. Eight of 14 tumors (57%) displayed abnormal FHIT products that lacked three or more exons of the FHIT gene. The pattern of abnormal transcripts was similar to that observed in small cell lung tumors, suggesting that FHIT abnormalities might be a common genetic marker of these two types of neuroendocrine tumors.

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