Abstract
OBJECTIVE: We investigated resting-state (RS)-fMRI using independent component analysis (ICA) to determine the functional connectivity (FC) between networks in chronic migraine (CM) patients and their correlation with clinical features. METHODS: Twenty CM patients without preventive therapy or acute medication overuse underwent 3T MRI scans and were compared to a group of 20 healthy controls (HC). We used MRI to collect RS data in 3 selected networks, identified using group ICA: the default mode network (DMN), the executive control network (ECN), and the dorsal attention system (DAS). RESULTS: Compared to HC, CM patients had significantly reduced functional connectivity between the DMN and the ECN. Moreover, in patients, the DAS showed significantly stronger FC with the DMN and weaker FC with the ECN. The higher the severity of headache, the increased the strength of DAS connectivity, and the lower the strength of ECN connectivity. CONCLUSION: These results provide evidence for large-scale reorganization of functional cortical networks in chronic migraine. They suggest that the severity of headache is associated with opposite connectivity patterns in frontal executive and dorsal attentional networks.
| Original language | English |
|---|---|
| Pages (from-to) | e2550-e2558 |
| Journal | Neurology |
| Volume | 92 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - May 28 2019 |
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ASJC Scopus subject areas
- Clinical Neurology
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Aberrant interactions of cortical networks in chronic migraine : A resting-state fMRI study. / Coppola, Gianluca; Di Renzo, Antonio; Petolicchio, Barbara; Tinelli, Emanuele; Di Lorenzo, Cherubino; Parisi, Vincenzo; Serrao, Mariano; Calistri, Valentina; Tardioli, Stefano; Cartocci, Gaia; Schoenen, Jean; Caramia, Francesca; Di Piero, Vittorio; Pierelli, Francesco.
In: Neurology, Vol. 92, No. 22, 28.05.2019, p. e2550-e2558.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Aberrant interactions of cortical networks in chronic migraine
T2 - A resting-state fMRI study
AU - Coppola, Gianluca
AU - Di Renzo, Antonio
AU - Petolicchio, Barbara
AU - Tinelli, Emanuele
AU - Di Lorenzo, Cherubino
AU - Parisi, Vincenzo
AU - Serrao, Mariano
AU - Calistri, Valentina
AU - Tardioli, Stefano
AU - Cartocci, Gaia
AU - Schoenen, Jean
AU - Caramia, Francesca
AU - Di Piero, Vittorio
AU - Pierelli, Francesco
PY - 2019/5/28
Y1 - 2019/5/28
N2 - OBJECTIVE: We investigated resting-state (RS)-fMRI using independent component analysis (ICA) to determine the functional connectivity (FC) between networks in chronic migraine (CM) patients and their correlation with clinical features. METHODS: Twenty CM patients without preventive therapy or acute medication overuse underwent 3T MRI scans and were compared to a group of 20 healthy controls (HC). We used MRI to collect RS data in 3 selected networks, identified using group ICA: the default mode network (DMN), the executive control network (ECN), and the dorsal attention system (DAS). RESULTS: Compared to HC, CM patients had significantly reduced functional connectivity between the DMN and the ECN. Moreover, in patients, the DAS showed significantly stronger FC with the DMN and weaker FC with the ECN. The higher the severity of headache, the increased the strength of DAS connectivity, and the lower the strength of ECN connectivity. CONCLUSION: These results provide evidence for large-scale reorganization of functional cortical networks in chronic migraine. They suggest that the severity of headache is associated with opposite connectivity patterns in frontal executive and dorsal attentional networks.
AB - OBJECTIVE: We investigated resting-state (RS)-fMRI using independent component analysis (ICA) to determine the functional connectivity (FC) between networks in chronic migraine (CM) patients and their correlation with clinical features. METHODS: Twenty CM patients without preventive therapy or acute medication overuse underwent 3T MRI scans and were compared to a group of 20 healthy controls (HC). We used MRI to collect RS data in 3 selected networks, identified using group ICA: the default mode network (DMN), the executive control network (ECN), and the dorsal attention system (DAS). RESULTS: Compared to HC, CM patients had significantly reduced functional connectivity between the DMN and the ECN. Moreover, in patients, the DAS showed significantly stronger FC with the DMN and weaker FC with the ECN. The higher the severity of headache, the increased the strength of DAS connectivity, and the lower the strength of ECN connectivity. CONCLUSION: These results provide evidence for large-scale reorganization of functional cortical networks in chronic migraine. They suggest that the severity of headache is associated with opposite connectivity patterns in frontal executive and dorsal attentional networks.
UR - http://www.scopus.com/inward/record.url?scp=85066967437&partnerID=8YFLogxK
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U2 - 10.1212/WNL.0000000000007577
DO - 10.1212/WNL.0000000000007577
M3 - Article
VL - 92
SP - e2550-e2558
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 22
ER -