Aberrant interactions of cortical networks in chronic migraine: A resting-state fMRI study

Gianluca Coppola, Antonio Di Renzo, Barbara Petolicchio, Emanuele Tinelli, Cherubino Di Lorenzo, Vincenzo Parisi, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Jean Schoenen, Francesca Caramia, Vittorio Di Piero, Francesco Pierelli

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE: We investigated resting-state (RS)-fMRI using independent component analysis (ICA) to determine the functional connectivity (FC) between networks in chronic migraine (CM) patients and their correlation with clinical features. METHODS: Twenty CM patients without preventive therapy or acute medication overuse underwent 3T MRI scans and were compared to a group of 20 healthy controls (HC). We used MRI to collect RS data in 3 selected networks, identified using group ICA: the default mode network (DMN), the executive control network (ECN), and the dorsal attention system (DAS). RESULTS: Compared to HC, CM patients had significantly reduced functional connectivity between the DMN and the ECN. Moreover, in patients, the DAS showed significantly stronger FC with the DMN and weaker FC with the ECN. The higher the severity of headache, the increased the strength of DAS connectivity, and the lower the strength of ECN connectivity. CONCLUSION: These results provide evidence for large-scale reorganization of functional cortical networks in chronic migraine. They suggest that the severity of headache is associated with opposite connectivity patterns in frontal executive and dorsal attentional networks.

Original languageEnglish
Pages (from-to)e2550-e2558
JournalNeurology
Volume92
Issue number22
DOIs
Publication statusPublished - May 28 2019

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Executive Function
Migraine Disorders
Magnetic Resonance Imaging
Headache
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

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Aberrant interactions of cortical networks in chronic migraine : A resting-state fMRI study. / Coppola, Gianluca; Di Renzo, Antonio; Petolicchio, Barbara; Tinelli, Emanuele; Di Lorenzo, Cherubino; Parisi, Vincenzo; Serrao, Mariano; Calistri, Valentina; Tardioli, Stefano; Cartocci, Gaia; Schoenen, Jean; Caramia, Francesca; Di Piero, Vittorio; Pierelli, Francesco.

In: Neurology, Vol. 92, No. 22, 28.05.2019, p. e2550-e2558.

Research output: Contribution to journalArticle

Coppola, G, Di Renzo, A, Petolicchio, B, Tinelli, E, Di Lorenzo, C, Parisi, V, Serrao, M, Calistri, V, Tardioli, S, Cartocci, G, Schoenen, J, Caramia, F, Di Piero, V & Pierelli, F 2019, 'Aberrant interactions of cortical networks in chronic migraine: A resting-state fMRI study', Neurology, vol. 92, no. 22, pp. e2550-e2558. https://doi.org/10.1212/WNL.0000000000007577
Coppola, Gianluca ; Di Renzo, Antonio ; Petolicchio, Barbara ; Tinelli, Emanuele ; Di Lorenzo, Cherubino ; Parisi, Vincenzo ; Serrao, Mariano ; Calistri, Valentina ; Tardioli, Stefano ; Cartocci, Gaia ; Schoenen, Jean ; Caramia, Francesca ; Di Piero, Vittorio ; Pierelli, Francesco. / Aberrant interactions of cortical networks in chronic migraine : A resting-state fMRI study. In: Neurology. 2019 ; Vol. 92, No. 22. pp. e2550-e2558.
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AU - Serrao, Mariano

AU - Calistri, Valentina

AU - Tardioli, Stefano

AU - Cartocci, Gaia

AU - Schoenen, Jean

AU - Caramia, Francesca

AU - Di Piero, Vittorio

AU - Pierelli, Francesco

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