Abstract
The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.
| Original language | English |
|---|---|
| Pages (from-to) | 1405-1409 |
| Number of pages | 5 |
| Journal | Haematologica |
| Volume | 91 |
| Issue number | 10 |
| Publication status | Published - Oct 2006 |
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Keywords
- Aberrant somatic hypermutation
- Chronic lymphocytic leukemia
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Histologic transformation
ASJC Scopus subject areas
- Hematology
Cite this
Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. / Rossi, Davide; Berra, Eva; Cerri, Michaela; Deambrogi, Clara; Barbieri, Caterina; Franceschetti, Silvia; Lunghi, Monia; Conconi, Annarita; Paulli, Marco; Matolcsy, Andràs; Pasqualucci, Laura; Capello, Daniela; Gaidano, Gianluca.
In: Haematologica, Vol. 91, No. 10, 10.2006, p. 1405-1409.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma
AU - Rossi, Davide
AU - Berra, Eva
AU - Cerri, Michaela
AU - Deambrogi, Clara
AU - Barbieri, Caterina
AU - Franceschetti, Silvia
AU - Lunghi, Monia
AU - Conconi, Annarita
AU - Paulli, Marco
AU - Matolcsy, Andràs
AU - Pasqualucci, Laura
AU - Capello, Daniela
AU - Gaidano, Gianluca
PY - 2006/10
Y1 - 2006/10
N2 - The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.
AB - The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.
KW - Aberrant somatic hypermutation
KW - Chronic lymphocytic leukemia
KW - Diffuse large B-cell lymphoma
KW - Follicular lymphoma
KW - Histologic transformation
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UR - http://www.scopus.com/inward/citedby.url?scp=33750022561&partnerID=8YFLogxK
M3 - Article
VL - 91
SP - 1405
EP - 1409
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 10
ER -