Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Davide Rossi, Eva Berra, Michaela Cerri, Clara Deambrogi, Caterina Barbieri, Silvia Franceschetti, Monia Lunghi, Annarita Conconi, Marco Paulli, Andràs Matolcsy, Laura Pasqualucci, Daniela Capello, Gianluca Gaidano

Research output: Contribution to journalArticle

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Abstract

The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

Original languageEnglish
Pages (from-to)1405-1409
Number of pages5
JournalHaematologica
Volume91
Issue number10
Publication statusPublished - Oct 2006

Fingerprint

Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
B-Cell Chronic Lymphocytic Leukemia
Mutation
Genes

Keywords

  • Aberrant somatic hypermutation
  • Chronic lymphocytic leukemia
  • Diffuse large B-cell lymphoma
  • Follicular lymphoma
  • Histologic transformation

ASJC Scopus subject areas

  • Hematology

Cite this

Rossi, D., Berra, E., Cerri, M., Deambrogi, C., Barbieri, C., Franceschetti, S., ... Gaidano, G. (2006). Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. Haematologica, 91(10), 1405-1409.

Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. / Rossi, Davide; Berra, Eva; Cerri, Michaela; Deambrogi, Clara; Barbieri, Caterina; Franceschetti, Silvia; Lunghi, Monia; Conconi, Annarita; Paulli, Marco; Matolcsy, Andràs; Pasqualucci, Laura; Capello, Daniela; Gaidano, Gianluca.

In: Haematologica, Vol. 91, No. 10, 10.2006, p. 1405-1409.

Research output: Contribution to journalArticle

Rossi, D, Berra, E, Cerri, M, Deambrogi, C, Barbieri, C, Franceschetti, S, Lunghi, M, Conconi, A, Paulli, M, Matolcsy, A, Pasqualucci, L, Capello, D & Gaidano, G 2006, 'Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma', Haematologica, vol. 91, no. 10, pp. 1405-1409.
Rossi D, Berra E, Cerri M, Deambrogi C, Barbieri C, Franceschetti S et al. Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. Haematologica. 2006 Oct;91(10):1405-1409.
Rossi, Davide ; Berra, Eva ; Cerri, Michaela ; Deambrogi, Clara ; Barbieri, Caterina ; Franceschetti, Silvia ; Lunghi, Monia ; Conconi, Annarita ; Paulli, Marco ; Matolcsy, Andràs ; Pasqualucci, Laura ; Capello, Daniela ; Gaidano, Gianluca. / Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. In: Haematologica. 2006 ; Vol. 91, No. 10. pp. 1405-1409.
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