Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Davide Rossi; Eva Berra; Michaela Cerri; Clara Deambrogi; Caterina Barbieri; Silvia Franceschetti; Monia Lunghi; Annarita Conconi; Marco Paulli; Andràs Matolcsy; Laura Pasqualucci; Daniela Capello; Gianluca Gaidano

Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Davide Rossi, Eva Berra, Michaela Cerri, Clara Deambrogi, Caterina Barbieri, Silvia Franceschetti, Monia Lunghi, Annarita Conconi, Marco Paulli, Andràs Matolcsy, Laura Pasqualucci, Daniela Capello, Gianluca Gaidano

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

Original language	English
Pages (from-to)	1405-1409
Number of pages	5
Journal	Haematologica
Volume	91
Issue number	10
Publication status	Published - Oct 2006

Keywords

Aberrant somatic hypermutation
Chronic lymphocytic leukemia
Diffuse large B-cell lymphoma
Follicular lymphoma
Histologic transformation

ASJC Scopus subject areas

Hematology

Cite this

Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. / Rossi, Davide; Berra, Eva; Cerri, Michaela; Deambrogi, Clara; Barbieri, Caterina; Franceschetti, Silvia; Lunghi, Monia; Conconi, Annarita; Paulli, Marco; Matolcsy, Andràs; Pasqualucci, Laura; Capello, Daniela; Gaidano, Gianluca.

In: Haematologica, Vol. 91, No. 10, 10.2006, p. 1405-1409.

Research output: Contribution to journal › Article › peer-review

Rossi, Davide ; Berra, Eva ; Cerri, Michaela ; Deambrogi, Clara ; Barbieri, Caterina ; Franceschetti, Silvia ; Lunghi, Monia ; Conconi, Annarita ; Paulli, Marco ; Matolcsy, Andràs ; Pasqualucci, Laura ; Capello, Daniela ; Gaidano, Gianluca. / Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. In: Haematologica. 2006 ; Vol. 91, No. 10. pp. 1405-1409.

@article{1f8a17bf0c3f4d3b81ff68dba4963951,

title = "Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma",

abstract = "The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.",

keywords = "Aberrant somatic hypermutation, Chronic lymphocytic leukemia, Diffuse large B-cell lymphoma, Follicular lymphoma, Histologic transformation",

author = "Davide Rossi and Eva Berra and Michaela Cerri and Clara Deambrogi and Caterina Barbieri and Silvia Franceschetti and Monia Lunghi and Annarita Conconi and Marco Paulli and Andr{\`a}s Matolcsy and Laura Pasqualucci and Daniela Capello and Gianluca Gaidano",

year = "2006",

month = oct,

language = "English",

volume = "91",

pages = "1405--1409",

journal = "Haematologica",

issn = "0390-6078",

publisher = "NLM (Medline)",

number = "10",

}

TY - JOUR

T1 - Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

AU - Rossi, Davide

AU - Berra, Eva

AU - Cerri, Michaela

AU - Deambrogi, Clara

AU - Barbieri, Caterina

AU - Franceschetti, Silvia

AU - Lunghi, Monia

AU - Conconi, Annarita

AU - Paulli, Marco

AU - Matolcsy, Andràs

AU - Pasqualucci, Laura

AU - Capello, Daniela

AU - Gaidano, Gianluca

PY - 2006/10

Y1 - 2006/10

N2 - The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

AB - The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

KW - Aberrant somatic hypermutation

KW - Chronic lymphocytic leukemia

KW - Diffuse large B-cell lymphoma

KW - Follicular lymphoma

KW - Histologic transformation

UR - http://www.scopus.com/inward/record.url?scp=33750022561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750022561&partnerID=8YFLogxK

M3 - Article

C2 - 17018394

AN - SCOPUS:33750022561

VL - 91

SP - 1405

EP - 1409

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 10

ER -

Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this