Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Davide Rossi, Eva Berra, Michaela Cerri, Clara Deambrogi, Caterina Barbieri, Silvia Franceschetti, Monia Lunghi, Annarita Conconi, Marco Paulli, Andràs Matolcsy, Laura Pasqualucci, Daniela Capello, Gianluca Gaidano

Research output: Contribution to journalArticlepeer-review

Abstract

The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

Original languageEnglish
Pages (from-to)1405-1409
Number of pages5
JournalHaematologica
Volume91
Issue number10
Publication statusPublished - Oct 2006

Keywords

  • Aberrant somatic hypermutation
  • Chronic lymphocytic leukemia
  • Diffuse large B-cell lymphoma
  • Follicular lymphoma
  • Histologic transformation

ASJC Scopus subject areas

  • Hematology

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