Abstract
The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.
| Original language | English |
|---|---|
| Pages (from-to) | 1405-1409 |
| Number of pages | 5 |
| Journal | Haematologica |
| Volume | 91 |
| Issue number | 10 |
| Publication status | Published - Oct 2006 |
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Keywords
- Aberrant somatic hypermutation
- Chronic lymphocytic leukemia
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Histologic transformation
ASJC Scopus subject areas
- Hematology
Cite this
Rossi, D., Berra, E., Cerri, M., Deambrogi, C., Barbieri, C., Franceschetti, S., Lunghi, M., Conconi, A., Paulli, M., Matolcsy, A., Pasqualucci, L., Capello, D., & Gaidano, G. (2006). Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. Haematologica, 91(10), 1405-1409.