Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Davide Rossi; Eva Berra; Michaela Cerri; Clara Deambrogi; Caterina Barbieri; Silvia Franceschetti; Monia Lunghi; Annarita Conconi; Marco Paulli; Andràs Matolcsy; Laura Pasqualucci; Daniela Capello; Gianluca Gaidano

Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Davide Rossi, Eva Berra, Michaela Cerri, Clara Deambrogi, Caterina Barbieri, Silvia Franceschetti, Monia Lunghi, Annarita Conconi, Marco Paulli, Andràs Matolcsy, Laura Pasqualucci, Daniela Capello, Gianluca Gaidano

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

Original language	English
Pages (from-to)	1405-1409
Number of pages	5
Journal	Haematologica
Volume	91
Issue number	10
Publication status	Published - Oct 2006

Keywords

Aberrant somatic hypermutation
Chronic lymphocytic leukemia
Diffuse large B-cell lymphoma
Follicular lymphoma
Histologic transformation

ASJC Scopus subject areas

Hematology

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Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. / Rossi, Davide; Berra, Eva; Cerri, Michaela; Deambrogi, Clara; Barbieri, Caterina; Franceschetti, Silvia; Lunghi, Monia; Conconi, Annarita; Paulli, Marco; Matolcsy, Andràs; Pasqualucci, Laura; Capello, Daniela; Gaidano, Gianluca.

In: Haematologica, Vol. 91, No. 10, 10.2006, p. 1405-1409.

Research output: Contribution to journal › Article › peer-review

Rossi, Davide ; Berra, Eva ; Cerri, Michaela ; Deambrogi, Clara ; Barbieri, Caterina ; Franceschetti, Silvia ; Lunghi, Monia ; Conconi, Annarita ; Paulli, Marco ; Matolcsy, Andràs ; Pasqualucci, Laura ; Capello, Daniela ; Gaidano, Gianluca. / Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. In: Haematologica. 2006 ; Vol. 91, No. 10. pp. 1405-1409.

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abstract = "The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.",

keywords = "Aberrant somatic hypermutation, Chronic lymphocytic leukemia, Diffuse large B-cell lymphoma, Follicular lymphoma, Histologic transformation",

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AU - Rossi, Davide

AU - Berra, Eva

AU - Cerri, Michaela

AU - Deambrogi, Clara

AU - Barbieri, Caterina

AU - Franceschetti, Silvia

AU - Lunghi, Monia

AU - Conconi, Annarita

AU - Paulli, Marco

AU - Matolcsy, Andràs

AU - Pasqualucci, Laura

AU - Capello, Daniela

AU - Gaidano, Gianluca

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N2 - The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

AB - The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

KW - Aberrant somatic hypermutation

KW - Chronic lymphocytic leukemia

KW - Diffuse large B-cell lymphoma

KW - Follicular lymphoma

KW - Histologic transformation

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Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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