Abl interconnects oncogenic Met and p53 core pathways in cancer cells

A. Furlan, V. Stagni, A. Hussain, S. Richelme, F. Conti, A. Prodosmo, A. Destro, M. Roncalli, D. Barilà, F. Mainá

Research output: Contribution to journalArticle

Abstract

The simplicity of BCR-ABL oncogene addiction characterizing leukemia contrasts with the complexity of solid tumors where multiple core pathways, including receptor tyrosine kinases (RTKs) and p53, are often altered. This discrepancy illustrates the limited success of RTK antagonists in solid tumor treatment compared with the impact of Imatinib in BCR-ABL-dependent leukemia. Here, we identified c-Abl as a signaling node interconnecting Met-RTK and p53 core pathways, and showed that its inhibition impairs Met-dependent tumorigenesis. Met ensures cell survival through a new path in which c-Abl and p38-MAPK are employed to elicit p53 phosphorylation on Ser 392 and Mdm2 upregulation. We found a clinical correlation between activated Met, phospho-p53, and Mdm2 levels in human tumors, supporting the role of this path in tumorigenesis. Our findings introduce the concept that RTK-driven tumors may be therapeutically treated by hitting signaling nodes interconnecting core pathways. Moreover, they underline the importance of evaluating the relevance of c-Abl antagonists for combined therapies, based on the tumor signaling signature.

Original languageEnglish
Pages (from-to)1608-1616
Number of pages9
JournalCell Death and Differentiation
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Keywords

  • c-Abl
  • Met/HGF
  • oncogenic signals
  • p53
  • RTK signaling

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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