Abstract
Background Catheter ablation is a widely used approach to treat patients with drug refractory paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation (CAF). The aim of this analysis was to evaluate the long-term safety and efficacy of the multielectrode/phased radiofrequency (RF)/duty-cycled ablation catheters in the treatment of both PAF and CAF in a large cohort of patients. Methods and results From July 2008 to February 2010, 429 consecutive drug refractory symptomatic patients (mean age 60W12 years old, 58%men, 68%PAF, 32%CAF) were treated. Seventy-five patients had two procedures resulting in a total of 504 procedures (procedure mean time: 62W15min). Following ablation, 4-day continuous Holter monitoring was done every 3 months. Recurrence was defined as any atrial tachyarrhythmia of more than 30 s. At 3 months 97.4% of patients were off antiarrhythmic drugs. During a mean followup of 22W5 months, freedom from AF recurrence was 68.5% (95% CI: 63.8-72.6) and higher for PAF than CAF patients. The risk of AF recurrence in PAF patients increased in the presence of hypertension, dyslipidemia, large left atrial diameter (LAD) and lowejection fraction. ForCAF patients, the risk of AF recurrence increased with larger LAD and lower ejection fraction. Complications that resolved prior to discharge were observed in nine patients (2.1%) with no strokes/transient ischemic attacks (TIAs). Conclusion The ablation of symptomatic PAF and CAF with multielectrode phased radiofrequency/duty-cycled ablation catheters shows long-term safety and effectiveness with relatively short procedure times.
| Original language | English |
|---|---|
| Pages (from-to) | 879-885 |
| Number of pages | 7 |
| Journal | Journal of Cardiovascular Medicine |
| Volume | 14 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2013 |
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Keywords
- Atrial fibrillation
- Catheter ablation
- Duty-cycled radiofrequency
- Pulmonary vein isolation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Ablation of paroxysmal and persistent atrial fibrillation with multielectrode phased radiofrequency duty-cycled catheters : Long-term results from a large cohort of patients. / Nardi, Stefano; Argenziano, Luigi; Cappato, Riccardo; De Martino, Giuseppe; Esposito, Cristina; Scaglione, Mariano; Borrello, Francesco; Maglia, Giampiero.
In: Journal of Cardiovascular Medicine, Vol. 14, No. 12, 12.2013, p. 879-885.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ablation of paroxysmal and persistent atrial fibrillation with multielectrode phased radiofrequency duty-cycled catheters
T2 - Long-term results from a large cohort of patients
AU - Nardi, Stefano
AU - Argenziano, Luigi
AU - Cappato, Riccardo
AU - De Martino, Giuseppe
AU - Esposito, Cristina
AU - Scaglione, Mariano
AU - Borrello, Francesco
AU - Maglia, Giampiero
PY - 2013/12
Y1 - 2013/12
N2 - Background Catheter ablation is a widely used approach to treat patients with drug refractory paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation (CAF). The aim of this analysis was to evaluate the long-term safety and efficacy of the multielectrode/phased radiofrequency (RF)/duty-cycled ablation catheters in the treatment of both PAF and CAF in a large cohort of patients. Methods and results From July 2008 to February 2010, 429 consecutive drug refractory symptomatic patients (mean age 60W12 years old, 58%men, 68%PAF, 32%CAF) were treated. Seventy-five patients had two procedures resulting in a total of 504 procedures (procedure mean time: 62W15min). Following ablation, 4-day continuous Holter monitoring was done every 3 months. Recurrence was defined as any atrial tachyarrhythmia of more than 30 s. At 3 months 97.4% of patients were off antiarrhythmic drugs. During a mean followup of 22W5 months, freedom from AF recurrence was 68.5% (95% CI: 63.8-72.6) and higher for PAF than CAF patients. The risk of AF recurrence in PAF patients increased in the presence of hypertension, dyslipidemia, large left atrial diameter (LAD) and lowejection fraction. ForCAF patients, the risk of AF recurrence increased with larger LAD and lower ejection fraction. Complications that resolved prior to discharge were observed in nine patients (2.1%) with no strokes/transient ischemic attacks (TIAs). Conclusion The ablation of symptomatic PAF and CAF with multielectrode phased radiofrequency/duty-cycled ablation catheters shows long-term safety and effectiveness with relatively short procedure times.
AB - Background Catheter ablation is a widely used approach to treat patients with drug refractory paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation (CAF). The aim of this analysis was to evaluate the long-term safety and efficacy of the multielectrode/phased radiofrequency (RF)/duty-cycled ablation catheters in the treatment of both PAF and CAF in a large cohort of patients. Methods and results From July 2008 to February 2010, 429 consecutive drug refractory symptomatic patients (mean age 60W12 years old, 58%men, 68%PAF, 32%CAF) were treated. Seventy-five patients had two procedures resulting in a total of 504 procedures (procedure mean time: 62W15min). Following ablation, 4-day continuous Holter monitoring was done every 3 months. Recurrence was defined as any atrial tachyarrhythmia of more than 30 s. At 3 months 97.4% of patients were off antiarrhythmic drugs. During a mean followup of 22W5 months, freedom from AF recurrence was 68.5% (95% CI: 63.8-72.6) and higher for PAF than CAF patients. The risk of AF recurrence in PAF patients increased in the presence of hypertension, dyslipidemia, large left atrial diameter (LAD) and lowejection fraction. ForCAF patients, the risk of AF recurrence increased with larger LAD and lower ejection fraction. Complications that resolved prior to discharge were observed in nine patients (2.1%) with no strokes/transient ischemic attacks (TIAs). Conclusion The ablation of symptomatic PAF and CAF with multielectrode phased radiofrequency/duty-cycled ablation catheters shows long-term safety and effectiveness with relatively short procedure times.
KW - Atrial fibrillation
KW - Catheter ablation
KW - Duty-cycled radiofrequency
KW - Pulmonary vein isolation
UR - http://www.scopus.com/inward/record.url?scp=84890122184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890122184&partnerID=8YFLogxK
U2 - 10.2459/JCM.0b013e328360931a
DO - 10.2459/JCM.0b013e328360931a
M3 - Article
C2 - 23588029
AN - SCOPUS:84890122184
VL - 14
SP - 879
EP - 885
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
SN - 1558-2027
IS - 12
ER -