Ablative brain surgery

an overview

Andrea Franzini, Shayan Moosa, Domenico Servello, Isabella Small, Francesco DiMeco, Zhiyuan Xu, William Jeffrey Elias, Angelo Franzini, Francesco Prada

Research output: Contribution to journalArticle

Abstract

Background: Ablative therapies have been used for the treatment of neurological disorders for many years. They have been used both for creating therapeutic lesions within dysfunctional brain circuits and to destroy intracranial tumors and space-occupying masses. Despite the introduction of new effective drugs and neuromodulative techniques, which became more popular and subsequently caused brain ablation techniques to fall out favor, recent technological advances have led to the resurgence of lesioning with an improved safety profile. Currently, the four main ablative techniques that are used for ablative brain surgery are radiofrequency thermoablation, stereotactic radiosurgery, laser interstitial thermal therapy and magnetic resonance-guided focused ultrasound thermal ablation. Object: To review the physical principles underlying brain ablative therapies and to describe their use for neurological disorders. Methods: The literature regarding the neurosurgical applications of brain ablative therapies has been reviewed. Results: Ablative treatments have been used for several neurological disorders, including movement disorders, psychiatric disorders, chronic pain, drug-resistant epilepsy and brain tumors. Conclusions: There are several ongoing efforts to use novel ablative therapies directed towards the brain. The recent development of techniques that allow for precise targeting, accurate delivery of thermal doses and real-time visualization of induced tissue damage during the procedure have resulted in novel techniques for cerebral ablation such as magnetic resonance-guided focused ultrasound or laser interstitial thermal therapy. However, older techniques such as radiofrequency thermal ablation or stereotactic radiosurgery still have a pivotal role in the management of a variety of neurological disorders.

Original languageEnglish
Pages (from-to)64-80
Number of pages17
JournalInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Volume36
Issue number2
DOIs
Publication statusPublished - Oct 1 2019

Fingerprint

Brain
Nervous System Diseases
Hot Temperature
Ablation Techniques
Therapeutics
Radiosurgery
Lasers
Magnetic Resonance Spectroscopy
Movement Disorders
Brain Neoplasms
Chronic Pain
Psychiatry
Safety
Pharmaceutical Preparations
Neoplasms

Keywords

  • Cerebral ablation
  • high-intensity focused ultrasound
  • laser interstitial thermal therapy
  • magnetic resonance-guided focused ultrasound
  • radiofrequency
  • thermal lesioning

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cancer Research

Cite this

Ablative brain surgery : an overview. / Franzini, Andrea; Moosa, Shayan; Servello, Domenico; Small, Isabella; DiMeco, Francesco; Xu, Zhiyuan; Elias, William Jeffrey; Franzini, Angelo; Prada, Francesco.

In: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, Vol. 36, No. 2, 01.10.2019, p. 64-80.

Research output: Contribution to journalArticle

@article{6b48282110fa411a9ee6a09660f36560,
title = "Ablative brain surgery: an overview",
abstract = "Background: Ablative therapies have been used for the treatment of neurological disorders for many years. They have been used both for creating therapeutic lesions within dysfunctional brain circuits and to destroy intracranial tumors and space-occupying masses. Despite the introduction of new effective drugs and neuromodulative techniques, which became more popular and subsequently caused brain ablation techniques to fall out favor, recent technological advances have led to the resurgence of lesioning with an improved safety profile. Currently, the four main ablative techniques that are used for ablative brain surgery are radiofrequency thermoablation, stereotactic radiosurgery, laser interstitial thermal therapy and magnetic resonance-guided focused ultrasound thermal ablation. Object: To review the physical principles underlying brain ablative therapies and to describe their use for neurological disorders. Methods: The literature regarding the neurosurgical applications of brain ablative therapies has been reviewed. Results: Ablative treatments have been used for several neurological disorders, including movement disorders, psychiatric disorders, chronic pain, drug-resistant epilepsy and brain tumors. Conclusions: There are several ongoing efforts to use novel ablative therapies directed towards the brain. The recent development of techniques that allow for precise targeting, accurate delivery of thermal doses and real-time visualization of induced tissue damage during the procedure have resulted in novel techniques for cerebral ablation such as magnetic resonance-guided focused ultrasound or laser interstitial thermal therapy. However, older techniques such as radiofrequency thermal ablation or stereotactic radiosurgery still have a pivotal role in the management of a variety of neurological disorders.",
keywords = "Cerebral ablation, high-intensity focused ultrasound, laser interstitial thermal therapy, magnetic resonance-guided focused ultrasound, radiofrequency, thermal lesioning",
author = "Andrea Franzini and Shayan Moosa and Domenico Servello and Isabella Small and Francesco DiMeco and Zhiyuan Xu and Elias, {William Jeffrey} and Angelo Franzini and Francesco Prada",
year = "2019",
month = "10",
day = "1",
doi = "10.1080/02656736.2019.1616833",
language = "English",
volume = "36",
pages = "64--80",
journal = "International Journal of Hyperthermia",
issn = "0265-6736",
publisher = "ROUTLEDGE JOURNALS, TAYLOR FRANCIS LTD",
number = "2",

}

TY - JOUR

T1 - Ablative brain surgery

T2 - an overview

AU - Franzini, Andrea

AU - Moosa, Shayan

AU - Servello, Domenico

AU - Small, Isabella

AU - DiMeco, Francesco

AU - Xu, Zhiyuan

AU - Elias, William Jeffrey

AU - Franzini, Angelo

AU - Prada, Francesco

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Ablative therapies have been used for the treatment of neurological disorders for many years. They have been used both for creating therapeutic lesions within dysfunctional brain circuits and to destroy intracranial tumors and space-occupying masses. Despite the introduction of new effective drugs and neuromodulative techniques, which became more popular and subsequently caused brain ablation techniques to fall out favor, recent technological advances have led to the resurgence of lesioning with an improved safety profile. Currently, the four main ablative techniques that are used for ablative brain surgery are radiofrequency thermoablation, stereotactic radiosurgery, laser interstitial thermal therapy and magnetic resonance-guided focused ultrasound thermal ablation. Object: To review the physical principles underlying brain ablative therapies and to describe their use for neurological disorders. Methods: The literature regarding the neurosurgical applications of brain ablative therapies has been reviewed. Results: Ablative treatments have been used for several neurological disorders, including movement disorders, psychiatric disorders, chronic pain, drug-resistant epilepsy and brain tumors. Conclusions: There are several ongoing efforts to use novel ablative therapies directed towards the brain. The recent development of techniques that allow for precise targeting, accurate delivery of thermal doses and real-time visualization of induced tissue damage during the procedure have resulted in novel techniques for cerebral ablation such as magnetic resonance-guided focused ultrasound or laser interstitial thermal therapy. However, older techniques such as radiofrequency thermal ablation or stereotactic radiosurgery still have a pivotal role in the management of a variety of neurological disorders.

AB - Background: Ablative therapies have been used for the treatment of neurological disorders for many years. They have been used both for creating therapeutic lesions within dysfunctional brain circuits and to destroy intracranial tumors and space-occupying masses. Despite the introduction of new effective drugs and neuromodulative techniques, which became more popular and subsequently caused brain ablation techniques to fall out favor, recent technological advances have led to the resurgence of lesioning with an improved safety profile. Currently, the four main ablative techniques that are used for ablative brain surgery are radiofrequency thermoablation, stereotactic radiosurgery, laser interstitial thermal therapy and magnetic resonance-guided focused ultrasound thermal ablation. Object: To review the physical principles underlying brain ablative therapies and to describe their use for neurological disorders. Methods: The literature regarding the neurosurgical applications of brain ablative therapies has been reviewed. Results: Ablative treatments have been used for several neurological disorders, including movement disorders, psychiatric disorders, chronic pain, drug-resistant epilepsy and brain tumors. Conclusions: There are several ongoing efforts to use novel ablative therapies directed towards the brain. The recent development of techniques that allow for precise targeting, accurate delivery of thermal doses and real-time visualization of induced tissue damage during the procedure have resulted in novel techniques for cerebral ablation such as magnetic resonance-guided focused ultrasound or laser interstitial thermal therapy. However, older techniques such as radiofrequency thermal ablation or stereotactic radiosurgery still have a pivotal role in the management of a variety of neurological disorders.

KW - Cerebral ablation

KW - high-intensity focused ultrasound

KW - laser interstitial thermal therapy

KW - magnetic resonance-guided focused ultrasound

KW - radiofrequency

KW - thermal lesioning

UR - http://www.scopus.com/inward/record.url?scp=85072371474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072371474&partnerID=8YFLogxK

U2 - 10.1080/02656736.2019.1616833

DO - 10.1080/02656736.2019.1616833

M3 - Article

VL - 36

SP - 64

EP - 80

JO - International Journal of Hyperthermia

JF - International Journal of Hyperthermia

SN - 0265-6736

IS - 2

ER -