Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura

Bruno Barbiroli; P. Montagna; P. Cortelli; R. Funicello; S. Iotti; L. Monari; G. Pierangeli; P. Zaniol; E. Lugaresi

Abnormal brain and muscle energy metabolism shown by ³¹P magnetic resonance spectroscopy in patients affected by migraine with aura

Bruno Barbiroli, P. Montagna, P. Cortelli, R. Funicello, S. Iotti, L. Monari, G. Pierangeli, P. Zaniol, E. Lugaresi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

We studied brain and muscle energy metabolism by phosphorus 31 magnetic resonance spectroscopy (³¹ P-MRS) in 12 patients affected by migraine with aura (classic migraine) in interictal periods. Brain ³¹ P-MRS disclosed a low phosphocreatine content in all patients, accompanied by high adenosine diphosphate concentration, a high percentage of V/V _max (adenosine triphosphate), and a low phosphorylation potential—features showing an unstable state of metabolism in classic migraine. Abnormal muscle mitochondrial function, in the absence of clinical signs of muscle impairment, was present in nine of the 12 patients examined.

Original language	English
Pages (from-to)	1209-1214
Number of pages	6
Journal	Neurology
Volume	42
Issue number	6
Publication status	Published - 1992

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology
Neuroscience(all)

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Abnormal brain and muscle energy metabolism shown by ³¹P magnetic resonance spectroscopy in patients affected by migraine with aura. / Barbiroli, Bruno; Montagna, P.; Cortelli, P.; Funicello, R.; Iotti, S.; Monari, L.; Pierangeli, G.; Zaniol, P.; Lugaresi, E.

In: Neurology, Vol. 42, No. 6, 1992, p. 1209-1214.

Research output: Contribution to journal › Article › peer-review

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abstract = "We studied brain and muscle energy metabolism by phosphorus 31 magnetic resonance spectroscopy (31 P-MRS) in 12 patients affected by migraine with aura (classic migraine) in interictal periods. Brain 31 P-MRS disclosed a low phosphocreatine content in all patients, accompanied by high adenosine diphosphate concentration, a high percentage of V/V max (adenosine triphosphate), and a low phosphorylation potential—features showing an unstable state of metabolism in classic migraine. Abnormal muscle mitochondrial function, in the absence of clinical signs of muscle impairment, was present in nine of the 12 patients examined.",

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AU - Barbiroli, Bruno

AU - Montagna, P.

AU - Cortelli, P.

AU - Funicello, R.

AU - Iotti, S.

AU - Monari, L.

AU - Pierangeli, G.

AU - Zaniol, P.

AU - Lugaresi, E.

PY - 1992

Y1 - 1992

N2 - We studied brain and muscle energy metabolism by phosphorus 31 magnetic resonance spectroscopy (31 P-MRS) in 12 patients affected by migraine with aura (classic migraine) in interictal periods. Brain 31 P-MRS disclosed a low phosphocreatine content in all patients, accompanied by high adenosine diphosphate concentration, a high percentage of V/V max (adenosine triphosphate), and a low phosphorylation potential—features showing an unstable state of metabolism in classic migraine. Abnormal muscle mitochondrial function, in the absence of clinical signs of muscle impairment, was present in nine of the 12 patients examined.

AB - We studied brain and muscle energy metabolism by phosphorus 31 magnetic resonance spectroscopy (31 P-MRS) in 12 patients affected by migraine with aura (classic migraine) in interictal periods. Brain 31 P-MRS disclosed a low phosphocreatine content in all patients, accompanied by high adenosine diphosphate concentration, a high percentage of V/V max (adenosine triphosphate), and a low phosphorylation potential—features showing an unstable state of metabolism in classic migraine. Abnormal muscle mitochondrial function, in the absence of clinical signs of muscle impairment, was present in nine of the 12 patients examined.

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JO - Neurology

JF - Neurology

SN - 0028-3878

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Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura

Abstract

ASJC Scopus subject areas

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Abnormal brain and muscle energy metabolism shown by ³¹P magnetic resonance spectroscopy in patients affected by migraine with aura