Abstract
We studied brain and muscle energy metabolism by phosphorus 31 magnetic resonance spectroscopy (31 P-MRS) in 12 patients affected by migraine with aura (classic migraine) in interictal periods. Brain 31 P-MRS disclosed a low phosphocreatine content in all patients, accompanied by high adenosine diphosphate concentration, a high percentage of V/V max (adenosine triphosphate), and a low phosphorylation potential—features showing an unstable state of metabolism in classic migraine. Abnormal muscle mitochondrial function, in the absence of clinical signs of muscle impairment, was present in nine of the 12 patients examined.
| Original language | English |
|---|---|
| Pages (from-to) | 1209-1214 |
| Number of pages | 6 |
| Journal | Neurology |
| Volume | 42 |
| Issue number | 6 |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology
- Neuroscience(all)
Cite this
Barbiroli, B., Montagna, P., Cortelli, P., Funicello, R., Iotti, S., Monari, L., Pierangeli, G., Zaniol, P., & Lugaresi, E. (1992). Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura. Neurology, 42(6), 1209-1214.