Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura

Bruno Barbiroli, P. Montagna, P. Cortelli, R. Funicello, S. Iotti, L. Monari, G. Pierangeli, P. Zaniol, E. Lugaresi

Research output: Contribution to journalArticle

Abstract

We studied brain and muscle energy metabolism by phosphorus 31 magnetic resonance spectroscopy (31 P-MRS) in 12 patients affected by migraine with aura (classic migraine) in interictal periods. Brain 31 P-MRS disclosed a low phosphocreatine content in all patients, accompanied by high adenosine diphosphate concentration, a high percentage of V/V max (adenosine triphosphate), and a low phosphorylation potential—features showing an unstable state of metabolism in classic migraine. Abnormal muscle mitochondrial function, in the absence of clinical signs of muscle impairment, was present in nine of the 12 patients examined.

Original languageEnglish
Pages (from-to)1209-1214
Number of pages6
JournalNeurology
Volume42
Issue number6
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Barbiroli, B., Montagna, P., Cortelli, P., Funicello, R., Iotti, S., Monari, L., Pierangeli, G., Zaniol, P., & Lugaresi, E. (1992). Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura. Neurology, 42(6), 1209-1214.