We studied brain and muscle energy metabolism by phosphorus 31 magnetic resonance spectroscopy (31 P-MRS) in 12 patients affected by migraine with aura (classic migraine) in interictal periods. Brain 31 P-MRS disclosed a low phosphocreatine content in all patients, accompanied by high adenosine diphosphate concentration, a high percentage of V/V max (adenosine triphosphate), and a low phosphorylation potential—features showing an unstable state of metabolism in classic migraine. Abnormal muscle mitochondrial function, in the absence of clinical signs of muscle impairment, was present in nine of the 12 patients examined.
|Number of pages||6|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology