Abnormal cardiac adrenergic nerve function in patients with syndrome X detected by [123I]Metaiodobenzylguanidine myocardial scintigraphy

Gaetano Antonio Lanza, Alessandro Giordano, Christian Pristipino, Maria Lucia Calcagni, Guido Meduri, Carlo Trani, Rodolfo Franceschini, Filippo Crea, Luigi Troncone, Attilio Maseri

Research output: Contribution to journalArticle

Abstract

Background: Previous studies have suggested that an abnormal cardiac adrenergic tone may have a pathophysiological role in syndrome X (effort angina, positive exercise testing, angiographically normal coronary arteries). Methods and Results: To evaluate cardiac adrenergic nerve function, we performed [123I]metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 12 patients with syndrome X and 10 control subjects. Cardiac MIBG uptake was assessed by the heart/mediastinum (H/M) ratio and by an MIBG uptake defect score (higher values=lower uptake). In syndrome X patients, we also correlated MIBG scintigraphic findings with stress myocardial perfusion as assessed by 201Tl scintigraphy. An inferior MIBG defect was observed in only 1 control subject, whereas 9 patients (P

Original languageEnglish
Pages (from-to)821-826
Number of pages6
JournalCirculation
Volume96
Issue number3
Publication statusPublished - Aug 5 1997

    Fingerprint

Keywords

  • Nervous system, adrenergic
  • Scintigraphy
  • Syndrome X

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Lanza, G. A., Giordano, A., Pristipino, C., Calcagni, M. L., Meduri, G., Trani, C., Franceschini, R., Crea, F., Troncone, L., & Maseri, A. (1997). Abnormal cardiac adrenergic nerve function in patients with syndrome X detected by [123I]Metaiodobenzylguanidine myocardial scintigraphy. Circulation, 96(3), 821-826.