Abnormal cardiocoronary thromboxane A2 production in patients with unstable angina

Gian Gastone Neri Serneri, Gian Franco Gensini, Rosanna Abbate, Domenico Prisco, Pier Giorgio Rogasi, Raffaele Laureano, Gian Carlo Casolo, Fabio Fantini, Marisa Di Donato, Roberto Piero Dabizzi

Research output: Contribution to journalArticle

Abstract

Thromboxane B2 (TXB2), the stable metabolite of thromboxane A2 (TXA2), was measured in the coronary sinus and in aortic blood before and after cold pressor test (CPT) in 21 patients suffering from ischemic heart disease (7 affected by stable effort angina and 14 by unstable angina) and in 12 patients not suffering from myocardial ischemia (control group) during coronary angiography. Aspirin (10 mg/kg intravenously) was administered before catheterization in order to prevent platelet and leukocyte TXA2 formation. Control subjects and patients with effort angina had TXB2 resting levels lower than unstable angina patients without a transcardiac gradient which, on the contrary, was found in unstable angina patients. Only in these patients CPT resulted in a significant TXB2 increase more marked in the coronary sinus (from 50.0 ± 18.9 pg/ml to 73.0 ± 35.1 pg/ml, p <0.001) than in the aorta (from 33.4 ± 17.1 pg/ml to 42.6 ± 24.0 pg/ml, p <0.05), so that the transcardiac TXB2 gradient significantly increased. In all but two unstable angina patients, TXB2 elevation was not associated with a fall of cardiac lactate extraction. The resting and CPT-induced TXB2 gradients were unrelated to the presence and severity of coronary angiographic lesions. These results indicate that unstable angina patients show an abnormal cardiocoronary capacity to synthesize TXA2, which seems not to be elicited by the occurrence of myocardial ischemia.

Original languageEnglish
Pages (from-to)732-738
Number of pages7
JournalAmerican Heart Journal
Volume109
Issue number4
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Neri Serneri, G. G., Gensini, G. F., Abbate, R., Prisco, D., Rogasi, P. G., Laureano, R., Casolo, G. C., Fantini, F., Donato, M. D., & Dabizzi, R. P. (1985). Abnormal cardiocoronary thromboxane A2 production in patients with unstable angina. American Heart Journal, 109(4), 732-738. https://doi.org/10.1016/0002-8703(85)90631-3