TY - JOUR
T1 - Abnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients
T2 - an electroencephalographic study
AU - Babiloni, Claudio
AU - Pascarelli, Maria Teresa
AU - Lizio, Roberta
AU - Noce, Giuseppe
AU - Lopez, Susanna
AU - Rizzo, Marco
AU - Ferri, Raffaele
AU - Soricelli, Andrea
AU - Nobili, Flavio
AU - Arnaldi, Dario
AU - Famà, Francesco
AU - Orzi, Francesco
AU - Buttinelli, Carla
AU - Giubilei, Franco
AU - Salvetti, Marco
AU - Cipollini, Virginia
AU - Bonanni, Laura
AU - Franciotti, Raffaella
AU - Onofrj, Marco
AU - Stirpe, Paola
AU - Fuhr, Peter
AU - Gschwandtner, Ute
AU - Ransmayr, Gerhard
AU - Aarsland, Dag
AU - Parnetti, Lucilla
AU - Farotti, Lucia
AU - Marizzoni, Moira
AU - D'Antonio, Fabrizia
AU - De Lena, Carlo
AU - Güntekin, Bahar
AU - Hanoğlu, Lutfu
AU - Yener, Görsev
AU - Emek-Savaş, Derya Durusu
AU - Triggiani, Antonio Ivano
AU - Taylor, John Paul
AU - McKeith, Ian
AU - Stocchi, Fabrizio
AU - Vacca, Laura
AU - Hampel, Harald
AU - Frisoni, Giovanni B.
AU - De Pandis, Maria Francesca
AU - Del Percio, Claudio
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Compared with Alzheimer's disease (AD), Parkinson's disease (PD) shows peculiar clinical manifestations related to vigilance (i.e., executive cognitive deficits and visual hallucinations) that may be reflected in resting-state electroencephalographic rhythms. To test this hypothesis, clinical and resting-state electroencephalographic rhythms in age-, sex-, and education-matched PD patients (N = 136) and Alzheimer's disease patients (AD, N = 85), and healthy older participants (Nold, N = 65), were available from an international archive. Electroencephalographic sources were estimated by eLORETA software. The results are as follows: (1) compared to the Nold participants, the AD and PD patients showed higher widespread delta source activities (PD > AD) and lower posterior alpha source activities (AD > PD); (2) the PD patients with the most pronounced motor deficits exhibited very low alpha source activities in widespread cortical regions; (3) the PD patients with the strongest cognitive deficits showed higher alpha source activities in widespread cortical regions; and (4) compared to the PD patients without visual hallucinations, those with visual hallucinations were characterized by higher posterior alpha sources activities. These results suggest that in PD patients resting in quiet wakefulness, abnormalities in cortical neural synchronization at alpha frequencies are differently related to cognitive, motor, and visual hallucinations. Interestingly, parallel PD neuropathological processes may have opposite effects on cortical neural synchronization mechanisms generating cortical alpha rhythms in quiet wakefulness.
AB - Compared with Alzheimer's disease (AD), Parkinson's disease (PD) shows peculiar clinical manifestations related to vigilance (i.e., executive cognitive deficits and visual hallucinations) that may be reflected in resting-state electroencephalographic rhythms. To test this hypothesis, clinical and resting-state electroencephalographic rhythms in age-, sex-, and education-matched PD patients (N = 136) and Alzheimer's disease patients (AD, N = 85), and healthy older participants (Nold, N = 65), were available from an international archive. Electroencephalographic sources were estimated by eLORETA software. The results are as follows: (1) compared to the Nold participants, the AD and PD patients showed higher widespread delta source activities (PD > AD) and lower posterior alpha source activities (AD > PD); (2) the PD patients with the most pronounced motor deficits exhibited very low alpha source activities in widespread cortical regions; (3) the PD patients with the strongest cognitive deficits showed higher alpha source activities in widespread cortical regions; and (4) compared to the PD patients without visual hallucinations, those with visual hallucinations were characterized by higher posterior alpha sources activities. These results suggest that in PD patients resting in quiet wakefulness, abnormalities in cortical neural synchronization at alpha frequencies are differently related to cognitive, motor, and visual hallucinations. Interestingly, parallel PD neuropathological processes may have opposite effects on cortical neural synchronization mechanisms generating cortical alpha rhythms in quiet wakefulness.
KW - Exact low-resolution brain electromagnetic source tomography (eLORETA)
KW - Mini-Mental State Evaluation (MMSE)
KW - Parkinson's disease (PD)
KW - Resting-state electroencephalographic (rsEEG) rhythms
KW - Unified Parkinson Disease Rating Scale-III (UPDRS III)
KW - Visual hallucinations
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UR - http://www.scopus.com/inward/citedby.url?scp=85082532046&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2020.02.029
DO - 10.1016/j.neurobiolaging.2020.02.029
M3 - Article
AN - SCOPUS:85082532046
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -