Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index

Claudio Babiloni; Alfredo Pennica; Claudio Del Percio; Giuseppe Noce; Susanna Cordone; Chiara Muratori; Stefano Ferracuti; Nicole Donato; Francesco Di Campli; Laura Gianserra; Elisabetta Teti; Antonio Aceti; Andrea Soricelli; Magdalena Viscione; Cristina Limatola; Massimo Andreoni; Paolo Onorati

doi:10.1016/j.clinph.2015.12.007

Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index

Claudio Babiloni, Alfredo Pennica, Claudio Del Percio, Giuseppe Noce, Susanna Cordone, Chiara Muratori, Stefano Ferracuti, Nicole Donato, Francesco Di Campli, Laura Gianserra, Elisabetta Teti, Antonio Aceti, Andrea Soricelli, Magdalena Viscione, Cristina Limatola, Massimo Andreoni, Paolo Onorati

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (

METHODS: Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.

RESULTS: Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (p

CONCLUSIONS: This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.

SIGNIFICANCE: This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.

Original language	English
Pages (from-to)	1803-1812
Number of pages	10
Journal	Clinical Neurophysiology
Volume	127
Issue number	3
DOIs	https://doi.org/10.1016/j.clinph.2015.12.007
Publication status	Published - Mar 1 2016

Keywords

Delta/alpha power density
Human immunodeficiency virus (HIV)
Low-resolution brain electromagnetic source tomography (LORETA)
Resting-state electroencephalography (EEG)
Z-score

ASJC Scopus subject areas

Medicine(all)

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10.1016/j.clinph.2015.12.007

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Babiloni, C., Pennica, A., Del Percio, C., Noce, G., Cordone, S., Muratori, C., Ferracuti, S., Donato, N., Di Campli, F., Gianserra, L., Teti, E., Aceti, A., Soricelli, A., Viscione, M., Limatola, C., Andreoni, M., & Onorati, P. (2016). Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index. Clinical Neurophysiology, 127(3), 1803-1812. https://doi.org/10.1016/j.clinph.2015.12.007

Babiloni, C, Pennica, A, Del Percio, C, Noce, G, Cordone, S, Muratori, C, Ferracuti, S, Donato, N, Di Campli, F, Gianserra, L, Teti, E, Aceti, A, Soricelli, A, Viscione, M, Limatola, C, Andreoni, M & Onorati, P 2016, 'Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index', Clinical Neurophysiology, vol. 127, no. 3, pp. 1803-1812. https://doi.org/10.1016/j.clinph.2015.12.007

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title = "Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-na{\"i}ve HIV individuals: A statistical z-score index",

abstract = "OBJECTIVE: This study tested a simple statistical procedure to recognize single treatment-na{\"i}ve HIV individuals having abnormal cortical sources of resting state delta (METHODS: Resting state eyes-closed EEG data were recorded in 82 treatment-na{\"i}ve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.RESULTS: Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-na{\"i}ve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-na{\"i}ve HIV individuals with reference to the healthy group (pCONCLUSIONS: This statistical procedure permitted for the first time to identify single treatment-na{\"i}ve HIV individuals having abnormal EEG activity.SIGNIFICANCE: This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-na{\"i}ve HIV individuals.",

keywords = "Delta/alpha power density, Human immunodeficiency virus (HIV), Low-resolution brain electromagnetic source tomography (LORETA), Resting-state electroencephalography (EEG), Z-score",

author = "Claudio Babiloni and Alfredo Pennica and {Del Percio}, Claudio and Giuseppe Noce and Susanna Cordone and Chiara Muratori and Stefano Ferracuti and Nicole Donato and {Di Campli}, Francesco and Laura Gianserra and Elisabetta Teti and Antonio Aceti and Andrea Soricelli and Magdalena Viscione and Cristina Limatola and Massimo Andreoni and Paolo Onorati",

year = "2016",

month = mar,

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doi = "10.1016/j.clinph.2015.12.007",

language = "English",

volume = "127",

pages = "1803--1812",

journal = "Clinical Neurophysiology",

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T1 - Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals

T2 - A statistical z-score index

AU - Babiloni, Claudio

AU - Pennica, Alfredo

AU - Del Percio, Claudio

AU - Noce, Giuseppe

AU - Cordone, Susanna

AU - Muratori, Chiara

AU - Ferracuti, Stefano

AU - Donato, Nicole

AU - Di Campli, Francesco

AU - Gianserra, Laura

AU - Teti, Elisabetta

AU - Aceti, Antonio

AU - Soricelli, Andrea

AU - Viscione, Magdalena

AU - Limatola, Cristina

AU - Andreoni, Massimo

AU - Onorati, Paolo

PY - 2016/3/1

Y1 - 2016/3/1

N2 - OBJECTIVE: This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (METHODS: Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.RESULTS: Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (pCONCLUSIONS: This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.SIGNIFICANCE: This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.

AB - OBJECTIVE: This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (METHODS: Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.RESULTS: Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (pCONCLUSIONS: This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.SIGNIFICANCE: This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.

KW - Delta/alpha power density

KW - Human immunodeficiency virus (HIV)

KW - Low-resolution brain electromagnetic source tomography (LORETA)

KW - Resting-state electroencephalography (EEG)

KW - Z-score

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Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index

Abstract

Keywords

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