Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index

Claudio Babiloni, Alfredo Pennica, Claudio Del Percio, Giuseppe Noce, Susanna Cordone, Chiara Muratori, Stefano Ferracuti, Nicole Donato, Francesco Di Campli, Laura Gianserra, Elisabetta Teti, Antonio Aceti, Andrea Soricelli, Magdalena Viscione, Cristina Limatola, Massimo Andreoni, Paolo Onorati

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (

METHODS: Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.

RESULTS: Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (p

CONCLUSIONS: This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.

SIGNIFICANCE: This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.

Original languageEnglish
Pages (from-to)1803-1812
Number of pages10
JournalClinical Neurophysiology
Volume127
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • Delta/alpha power density
  • Human immunodeficiency virus (HIV)
  • Low-resolution brain electromagnetic source tomography (LORETA)
  • Resting-state electroencephalography (EEG)
  • Z-score

ASJC Scopus subject areas

  • Medicine(all)

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    Babiloni, C., Pennica, A., Del Percio, C., Noce, G., Cordone, S., Muratori, C., Ferracuti, S., Donato, N., Di Campli, F., Gianserra, L., Teti, E., Aceti, A., Soricelli, A., Viscione, M., Limatola, C., Andreoni, M., & Onorati, P. (2016). Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index. Clinical Neurophysiology, 127(3), 1803-1812. https://doi.org/10.1016/j.clinph.2015.12.007