TY - JOUR
T1 - Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals
T2 - A statistical z-score index
AU - Babiloni, Claudio
AU - Pennica, Alfredo
AU - Del Percio, Claudio
AU - Noce, Giuseppe
AU - Cordone, Susanna
AU - Muratori, Chiara
AU - Ferracuti, Stefano
AU - Donato, Nicole
AU - Di Campli, Francesco
AU - Gianserra, Laura
AU - Teti, Elisabetta
AU - Aceti, Antonio
AU - Soricelli, Andrea
AU - Viscione, Magdalena
AU - Limatola, Cristina
AU - Andreoni, Massimo
AU - Onorati, Paolo
PY - 2016/3/1
Y1 - 2016/3/1
N2 - OBJECTIVE: This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (METHODS: Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.RESULTS: Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (pCONCLUSIONS: This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.SIGNIFICANCE: This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.
AB - OBJECTIVE: This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (METHODS: Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.RESULTS: Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (pCONCLUSIONS: This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.SIGNIFICANCE: This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.
KW - Delta/alpha power density
KW - Human immunodeficiency virus (HIV)
KW - Low-resolution brain electromagnetic source tomography (LORETA)
KW - Resting-state electroencephalography (EEG)
KW - Z-score
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U2 - 10.1016/j.clinph.2015.12.007
DO - 10.1016/j.clinph.2015.12.007
M3 - Article
C2 - 26762948
VL - 127
SP - 1803
EP - 1812
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 3
ER -