Abnormal dexamethasone suppression test in headaches: Effect of analgesic abuse

E. Martignoni, F. Facchinetti, G. Sances, L. Rocchi, R. Orlandi, A. R. Genazzani, G. Nappi

Research output: Contribution to journalArticlepeer-review


The response to dexamethasone suppression test (DST) in 13 subjects suffering from migraine without aura with coexisting chronic tension type headache, and abusing of instant-relief drugs was studied before and after analgesic withdrawal. Seventy-six per cent of the subjects was found to be non suppressor when abuser and 36% of them maintained the same response to DST after analgesic wash-out. These latter subjects showed a mild degree of depression and a daily pattern of plasma cortisol similar to that reported for depressed patients. These results suggest that in some patients headache and mood disorders coexist, possibly linked to a common psychobiological trait.

Original languageEnglish
Pages (from-to)401-407
Number of pages7
JournalNeuroendocrinology Letters
Issue number5
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)


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