Abnormal dexamethasone suppression test in headaches: Effect of analgesic abuse

E. Martignoni; F. Facchinetti; G. Sances; L. Rocchi; R. Orlandi; A. R. Genazzani; G. Nappi

Abnormal dexamethasone suppression test in headaches: Effect of analgesic abuse

E. Martignoni, F. Facchinetti, G. Sances, L. Rocchi, R. Orlandi, A. R. Genazzani, G. Nappi

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

The response to dexamethasone suppression test (DST) in 13 subjects suffering from migraine without aura with coexisting chronic tension type headache, and abusing of instant-relief drugs was studied before and after analgesic withdrawal. Seventy-six per cent of the subjects was found to be non suppressor when abuser and 36% of them maintained the same response to DST after analgesic wash-out. These latter subjects showed a mild degree of depression and a daily pattern of plasma cortisol similar to that reported for depressed patients. These results suggest that in some patients headache and mood disorders coexist, possibly linked to a common psychobiological trait.

Original language	English
Pages (from-to)	401-407
Number of pages	7
Journal	Neuroendocrinology Letters
Volume	12
Issue number	5
Publication status	Published - 1990

ASJC Scopus subject areas

Endocrinology
Neuroscience(all)

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abstract = "The response to dexamethasone suppression test (DST) in 13 subjects suffering from migraine without aura with coexisting chronic tension type headache, and abusing of instant-relief drugs was studied before and after analgesic withdrawal. Seventy-six per cent of the subjects was found to be non suppressor when abuser and 36% of them maintained the same response to DST after analgesic wash-out. These latter subjects showed a mild degree of depression and a daily pattern of plasma cortisol similar to that reported for depressed patients. These results suggest that in some patients headache and mood disorders coexist, possibly linked to a common psychobiological trait.",

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journal = "Neuroendocrinology Letters",

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T1 - Abnormal dexamethasone suppression test in headaches

T2 - Effect of analgesic abuse

AU - Martignoni, E.

AU - Facchinetti, F.

AU - Sances, G.

AU - Rocchi, L.

AU - Orlandi, R.

AU - Genazzani, A. R.

AU - Nappi, G.

PY - 1990

Y1 - 1990

N2 - The response to dexamethasone suppression test (DST) in 13 subjects suffering from migraine without aura with coexisting chronic tension type headache, and abusing of instant-relief drugs was studied before and after analgesic withdrawal. Seventy-six per cent of the subjects was found to be non suppressor when abuser and 36% of them maintained the same response to DST after analgesic wash-out. These latter subjects showed a mild degree of depression and a daily pattern of plasma cortisol similar to that reported for depressed patients. These results suggest that in some patients headache and mood disorders coexist, possibly linked to a common psychobiological trait.

AB - The response to dexamethasone suppression test (DST) in 13 subjects suffering from migraine without aura with coexisting chronic tension type headache, and abusing of instant-relief drugs was studied before and after analgesic withdrawal. Seventy-six per cent of the subjects was found to be non suppressor when abuser and 36% of them maintained the same response to DST after analgesic wash-out. These latter subjects showed a mild degree of depression and a daily pattern of plasma cortisol similar to that reported for depressed patients. These results suggest that in some patients headache and mood disorders coexist, possibly linked to a common psychobiological trait.

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