Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia

Daniele Belvisi, Antonio Suppa, Luca Marsili, Flavio Di Stasio, Ahmad Khandker Parvez, Rocco Agostino, Giovanni Fabbrini, Alfredo Berardelli

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Idiopathic focal hand dystonia (FHD) arises from abnormal plasticity in the primary motor cortex (M1) possibly reflecting abnormal sensori-motor integration processes. In this transcranial magnetic stimulation (TMS) study in FHD, we evaluated changes in motor evoked potentials (MEPs) after intermittent theta burst stimulation (iTBS) and paired associative stimulation (PAS), techniques that elicit different forms of experimentally-induced long-term potentiation (LTP)-like plasticity in M1. We also examined behaviorally-induced LTP-like plasticity as reflected by early motor learning of a simple motor task. We studied 14 patients with FHD and 14 healthy subjects. MEPs were recorded before and after iTBS and PAS at the 25ms interstimulus interval (PAS25) in separate sessions. Subjects did a simple motor task entailing repetitive index finger abductions. To measure early motor learning we tested practice-related improvement in peak velocity and peak acceleration. In FHD patients iTBS failed to elicit the expected MEP changes and PAS25 induced abnormally increased MEPs in target and non-target muscles. In the experiment testing early motor learning, patients lacked the expected practice-related changes in kinematic variables. In FHD, the degree of early motor learning correlated with patients' clinical features. We conclude that experimentally-induced (iTBS and PAS) and behaviorally-induced LTP-like plasticity are both altered in FHD.

Original languageEnglish
Pages (from-to)64-74
Number of pages11
JournalExperimental Neurology
Volume240
Issue number1
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Long-Term Potentiation
Motor Evoked Potentials
Learning
Transcranial Magnetic Stimulation
Motor Cortex
Biomechanical Phenomena
Fingers
Focal Task-Specific Dystonia
Healthy Volunteers
Muscles

Keywords

  • Dystonia
  • Early motor learning
  • Plasticity
  • Primary motor cortex
  • TMS

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia. / Belvisi, Daniele; Suppa, Antonio; Marsili, Luca; Di Stasio, Flavio; Parvez, Ahmad Khandker; Agostino, Rocco; Fabbrini, Giovanni; Berardelli, Alfredo.

In: Experimental Neurology, Vol. 240, No. 1, 02.2013, p. 64-74.

Research output: Contribution to journalArticle

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