Abnormal functional motor lateralization in healthy siblings of patients with schizophrenia

Mario Altamura; Leonardo Fazio; Michela De Salvia; Annamaria Petito; Giuseppe Blasi; Paolo Taurisano; Raffaella Romano; Barbara Gelao; Antonello Bellomo; Alessandro Bertolino

doi:10.1016/j.pscychresns.2012.02.008

Abnormal functional motor lateralization in healthy siblings of patients with schizophrenia

Mario Altamura, Leonardo Fazio, Michela De Salvia, Annamaria Petito, Giuseppe Blasi, Paolo Taurisano, Raffaella Romano, Barbara Gelao, Antonello Bellomo, Alessandro Bertolino

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Earlier neuroimaging studies of motor function in schizophrenia have demonstrated reduced functional lateralization in the motor network during motor tasks. Here, we used event-related functional magnetic resonance imaging during a visually guided motor task in 18 clinically unaffected siblings of patients with schizophrenia and 24 matched controls to investigate if abnormal functional lateralization is related to genetic risk for this brain disorder. Whereas activity associated with motor task performance was mainly contralateral with only a marginal ipsilateral component in healthy participants, unaffected siblings had strong bilateral activity with significantly greater response in ipsilateral and contralateral premotor areas as well as in contralateral subcortical motor regions relative to controls. Reduced lateralization in siblings was also identified with a measure of laterality quotient. These findings suggest that abnormal functional lateralization of motor circuitry is related to genetic risk of schizophrenia.

Original language	English
Pages (from-to)	54-60
Number of pages	7
Journal	Psychiatry Research - Neuroimaging
Volume	203
Issue number	1
DOIs	https://doi.org/10.1016/j.pscychresns.2012.02.008
Publication status	Published - Jul 30 2012

Keywords

FMRI
Functional lateralization
Genetic risk
Intermediate phenotype
Motor activity

ASJC Scopus subject areas

Psychiatry and Mental health
Radiology Nuclear Medicine and imaging
Neuroscience (miscellaneous)

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10.1016/j.pscychresns.2012.02.008

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Abnormal functional motor lateralization in healthy siblings of patients with schizophrenia. / Altamura, Mario; Fazio, Leonardo; De Salvia, Michela; Petito, Annamaria; Blasi, Giuseppe; Taurisano, Paolo; Romano, Raffaella; Gelao, Barbara; Bellomo, Antonello; Bertolino, Alessandro.

In: Psychiatry Research - Neuroimaging, Vol. 203, No. 1, 30.07.2012, p. 54-60.

Research output: Contribution to journal › Article › peer-review

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AU - Romano, Raffaella

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