TY - JOUR
T1 - Abnormal functional motor lateralization in healthy siblings of patients with schizophrenia
AU - Altamura, Mario
AU - Fazio, Leonardo
AU - De Salvia, Michela
AU - Petito, Annamaria
AU - Blasi, Giuseppe
AU - Taurisano, Paolo
AU - Romano, Raffaella
AU - Gelao, Barbara
AU - Bellomo, Antonello
AU - Bertolino, Alessandro
PY - 2012/7/30
Y1 - 2012/7/30
N2 - Earlier neuroimaging studies of motor function in schizophrenia have demonstrated reduced functional lateralization in the motor network during motor tasks. Here, we used event-related functional magnetic resonance imaging during a visually guided motor task in 18 clinically unaffected siblings of patients with schizophrenia and 24 matched controls to investigate if abnormal functional lateralization is related to genetic risk for this brain disorder. Whereas activity associated with motor task performance was mainly contralateral with only a marginal ipsilateral component in healthy participants, unaffected siblings had strong bilateral activity with significantly greater response in ipsilateral and contralateral premotor areas as well as in contralateral subcortical motor regions relative to controls. Reduced lateralization in siblings was also identified with a measure of laterality quotient. These findings suggest that abnormal functional lateralization of motor circuitry is related to genetic risk of schizophrenia.
AB - Earlier neuroimaging studies of motor function in schizophrenia have demonstrated reduced functional lateralization in the motor network during motor tasks. Here, we used event-related functional magnetic resonance imaging during a visually guided motor task in 18 clinically unaffected siblings of patients with schizophrenia and 24 matched controls to investigate if abnormal functional lateralization is related to genetic risk for this brain disorder. Whereas activity associated with motor task performance was mainly contralateral with only a marginal ipsilateral component in healthy participants, unaffected siblings had strong bilateral activity with significantly greater response in ipsilateral and contralateral premotor areas as well as in contralateral subcortical motor regions relative to controls. Reduced lateralization in siblings was also identified with a measure of laterality quotient. These findings suggest that abnormal functional lateralization of motor circuitry is related to genetic risk of schizophrenia.
KW - FMRI
KW - Functional lateralization
KW - Genetic risk
KW - Intermediate phenotype
KW - Motor activity
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UR - http://www.scopus.com/inward/citedby.url?scp=84866305321&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2012.02.008
DO - 10.1016/j.pscychresns.2012.02.008
M3 - Article
C2 - 22901767
AN - SCOPUS:84866305321
VL - 203
SP - 54
EP - 60
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
SN - 0925-4927
IS - 1
ER -