Abnormal growth hormone responsiveness to stimuli in women with active celiac sprue

M. Peracchi, N. Molteni, L. Cantalamessa, M. T. Bardella, G. Peracchi, A. Orsatti, P. Faggioli, P. A. Bianchi

Research output: Contribution to journalArticle

Abstract

Baseline somatomedin C (Sm-C) and responses of growth hormone (GH), prolactin (PRL), and thyrotropin (TSH) to TSH-releasing hormone (TRH) and to L-dopa were evaluated in 10 untreated and nine treated women with celiac sprue, and in 10 normal women. Mean basal Sm-C, GH, PRL, and TSH levels were similar in all groups of subjects. In all subjects, L-dopa decreased PRL levels, without affecting TSH, and TRH increased PRL and TSH levels. In both controls and treated patients, TRH did not influence GH secretion, whereas L- dopa significantly increased GH levels. In untreated patients, GH levels paradoxically increased after TRH (8/10) but were unaffected by L-dopa (7/10). Because L-dopa would stimulate hypothalamic GH-releasing hormone (GHRH) secretion, four untreated patients, unresponsive to L-dopa, received GHRH, and GH levels rose markedly. These data suggest that, in untreated celiac sprue patients, hypothalamic control of GH secretion is reversibly impaired.

Original languageEnglish
Pages (from-to)580-583
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume87
Issue number5
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Gastroenterology

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    Peracchi, M., Molteni, N., Cantalamessa, L., Bardella, M. T., Peracchi, G., Orsatti, A., Faggioli, P., & Bianchi, P. A. (1992). Abnormal growth hormone responsiveness to stimuli in women with active celiac sprue. American Journal of Gastroenterology, 87(5), 580-583.