Abnormal heart rate recovery after maximal cardiopulmonary exercise stress testing in young overweight women with polycystic ovary syndrome

Francesco Giallauria, Stefano Palomba, Francesco Manguso, Alessandra Vitelli, Luigi Maresca, Domenico Tafuri, Gaetano Lombardi, Annamaria Colao, Carlo Vigorito, Francesco Orio

Research output: Contribution to journalArticle

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Abstract

Objective: Heart rate recovery (HRR) is a measure derived from exercise test, defined as the fall in heart rate during the first minute after maximal exercise. Abnormal HRR is a measure of autonomic dysfunction associated with an increased mortality. This study was performed to evaluate the HRR in polycystic ovary syndrome (PCOS). Design: Prospective controlled clinical study. Patients: Seventy-five PCOS women compared to 75 healthy women matched for age (21.7 ± 2.1 years vs. 21.9 ± 1.8 years, respectively) and body mass index (BMI) (29.0 ± 2.6 kg/m 2 vs. 29.1 ± 2.9 kg/m 2, respectively). Measurements: Subjects were studied for their hormonal and metabolic profile, and underwent cardiopulmonary exercise test (CPX). Results: PCOS women showed a significantly reduced HRR (12.9 ± 1.8 vs. 20.4 ± 3.1 beats/min, P <0.001) compared to healthy controls, an impairment in maximal oxygen consumption (18.0 ± 2.3 ml/kg/min vs. 29.3 ± 3.9 ml/kg/min) and in oxygen consumption at anaerobic threshold (13.6 ± 2.6 ml/kg/min vs. 24.2 ± 3.0 ml/kg/min). In PCOS women, abnormal HRR was inversely correlated to BMI (r = -0.582, P <0.001) and to the area under the curve for insulin (r = -0.596, P <0.001). Conclusions: Our data demonstrate an abnormal HRR after maximal CPX in young overweight PCOS patients, and that HRR should be investigated as a further potential marker of increased cardiovascular risk in PCOS.

Original languageEnglish
Pages (from-to)88-93
Number of pages6
JournalClinical Endocrinology
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 2008

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Polycystic Ovary Syndrome
Heart Rate
Exercise
Exercise Test
Oxygen Consumption
Body Mass Index
Anaerobic Threshold
Metabolome
Area Under Curve
Insulin
Mortality

ASJC Scopus subject areas

  • Endocrinology

Cite this

Abnormal heart rate recovery after maximal cardiopulmonary exercise stress testing in young overweight women with polycystic ovary syndrome. / Giallauria, Francesco; Palomba, Stefano; Manguso, Francesco; Vitelli, Alessandra; Maresca, Luigi; Tafuri, Domenico; Lombardi, Gaetano; Colao, Annamaria; Vigorito, Carlo; Orio, Francesco.

In: Clinical Endocrinology, Vol. 68, No. 1, 01.2008, p. 88-93.

Research output: Contribution to journalArticle

Giallauria, F, Palomba, S, Manguso, F, Vitelli, A, Maresca, L, Tafuri, D, Lombardi, G, Colao, A, Vigorito, C & Orio, F 2008, 'Abnormal heart rate recovery after maximal cardiopulmonary exercise stress testing in young overweight women with polycystic ovary syndrome', Clinical Endocrinology, vol. 68, no. 1, pp. 88-93. https://doi.org/10.1111/j.1365-2265.2007.03004.x
Giallauria, Francesco ; Palomba, Stefano ; Manguso, Francesco ; Vitelli, Alessandra ; Maresca, Luigi ; Tafuri, Domenico ; Lombardi, Gaetano ; Colao, Annamaria ; Vigorito, Carlo ; Orio, Francesco. / Abnormal heart rate recovery after maximal cardiopulmonary exercise stress testing in young overweight women with polycystic ovary syndrome. In: Clinical Endocrinology. 2008 ; Vol. 68, No. 1. pp. 88-93.
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AU - Manguso, Francesco

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AU - Maresca, Luigi

AU - Tafuri, Domenico

AU - Lombardi, Gaetano

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AU - Orio, Francesco

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N2 - Objective: Heart rate recovery (HRR) is a measure derived from exercise test, defined as the fall in heart rate during the first minute after maximal exercise. Abnormal HRR is a measure of autonomic dysfunction associated with an increased mortality. This study was performed to evaluate the HRR in polycystic ovary syndrome (PCOS). Design: Prospective controlled clinical study. Patients: Seventy-five PCOS women compared to 75 healthy women matched for age (21.7 ± 2.1 years vs. 21.9 ± 1.8 years, respectively) and body mass index (BMI) (29.0 ± 2.6 kg/m 2 vs. 29.1 ± 2.9 kg/m 2, respectively). Measurements: Subjects were studied for their hormonal and metabolic profile, and underwent cardiopulmonary exercise test (CPX). Results: PCOS women showed a significantly reduced HRR (12.9 ± 1.8 vs. 20.4 ± 3.1 beats/min, P <0.001) compared to healthy controls, an impairment in maximal oxygen consumption (18.0 ± 2.3 ml/kg/min vs. 29.3 ± 3.9 ml/kg/min) and in oxygen consumption at anaerobic threshold (13.6 ± 2.6 ml/kg/min vs. 24.2 ± 3.0 ml/kg/min). In PCOS women, abnormal HRR was inversely correlated to BMI (r = -0.582, P <0.001) and to the area under the curve for insulin (r = -0.596, P <0.001). Conclusions: Our data demonstrate an abnormal HRR after maximal CPX in young overweight PCOS patients, and that HRR should be investigated as a further potential marker of increased cardiovascular risk in PCOS.

AB - Objective: Heart rate recovery (HRR) is a measure derived from exercise test, defined as the fall in heart rate during the first minute after maximal exercise. Abnormal HRR is a measure of autonomic dysfunction associated with an increased mortality. This study was performed to evaluate the HRR in polycystic ovary syndrome (PCOS). Design: Prospective controlled clinical study. Patients: Seventy-five PCOS women compared to 75 healthy women matched for age (21.7 ± 2.1 years vs. 21.9 ± 1.8 years, respectively) and body mass index (BMI) (29.0 ± 2.6 kg/m 2 vs. 29.1 ± 2.9 kg/m 2, respectively). Measurements: Subjects were studied for their hormonal and metabolic profile, and underwent cardiopulmonary exercise test (CPX). Results: PCOS women showed a significantly reduced HRR (12.9 ± 1.8 vs. 20.4 ± 3.1 beats/min, P <0.001) compared to healthy controls, an impairment in maximal oxygen consumption (18.0 ± 2.3 ml/kg/min vs. 29.3 ± 3.9 ml/kg/min) and in oxygen consumption at anaerobic threshold (13.6 ± 2.6 ml/kg/min vs. 24.2 ± 3.0 ml/kg/min). In PCOS women, abnormal HRR was inversely correlated to BMI (r = -0.582, P <0.001) and to the area under the curve for insulin (r = -0.596, P <0.001). Conclusions: Our data demonstrate an abnormal HRR after maximal CPX in young overweight PCOS patients, and that HRR should be investigated as a further potential marker of increased cardiovascular risk in PCOS.

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