Abnormal hypertensive response during exercise test in normotensive transplanted children and adolescents

M. Chiara Matteucci, Armando Calzolari, Emanuela Pompei, Flavia Principato, Attilio Turchetta, Gianfranco Rizzoni

Research output: Contribution to journalArticlepeer-review


We investigated the cardiovascular and respiratory conditions, at rest and in response to stress testing, in 10 children and adolescents with successful renal transplantation, to release certifications for participation in sports. Our patients were aged more than 6 years, transplanted 6 months or more before the study, with creatinine clearance > 40 mil/min/1.73 m2, without hypertension at rest. All but 1 were on cyclosporine A, prednisone and azathioprine. Two control study groups with the same chronological age and body surface area were paired with our patients. They underwent a graded exercise treadmill test, during which maximal blood pressure and heart rate were recorded. Resting electrocardiogram, dynamic 24-hour electrocardiogram Holter monitoring and mono- and bidimensional echocardiograms were obtained before the test. Spirometry was performed to study lung flow and volume. A questionnaire collected information about physical activity patterns. Four categories, according to practice, frequency and duration of exercise, were identified: nonactive, starters, experienced and very experienced. Most children and adolescents were sedentary or mildly interested in sports and during treadmill test we observed reduced exercise capacity and systolic hypertensive response to increasing exercise testing.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
Issue number2
Publication statusPublished - Jun 1996


  • Exercise testing
  • Hypertension
  • Questionnaire
  • Transplantation

ASJC Scopus subject areas

  • Nephrology


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