TY - JOUR
T1 - Abnormal modulatory influence of diffuse noxious inhibitory controls in migraine and chronic tension-type headache patients
AU - Sandrini, G.
AU - Rossi, P.
AU - Milanov, I.
AU - Serrao, M.
AU - Cecchini, A. P.
AU - Nappi, G.
PY - 2006/7
Y1 - 2006/7
N2 - The aim of this study was to evaluate the function of pain modulating systems subserving diffuse noxious inhibitory controls (DNICs) in primary headaches. DNICs were examined in 24 migraineurs, 17 patients with chronic tension-type headache (CTTH) and 20 healthy subjects by means of nociceptive flexion RIII reflex and the cold pressor test (CPT) as heterotopic noxious conditioning stimulation (HNCS). The subjective pain thresholds (Tp) and the RIII reflex threshold (Tr) were significantly lower in CTTH vs. controls. In controls a significant inhibition of the RIII reflex was observed during the CPT (-30%, P <0.05). Conversely, migraine and CTTH patients showed facilitation (+31%, P <0.05 and +40%, P <0.01, respectively) of the RIII reflex during the HNCS. This study demonstrates a dysfunction in systems subserving DNICs in both migraine and CTTH. Impairment of endogenous supraspinal pain modulation systems may contribute to the development and/or maintenance of central sensitization in primary headaches.
AB - The aim of this study was to evaluate the function of pain modulating systems subserving diffuse noxious inhibitory controls (DNICs) in primary headaches. DNICs were examined in 24 migraineurs, 17 patients with chronic tension-type headache (CTTH) and 20 healthy subjects by means of nociceptive flexion RIII reflex and the cold pressor test (CPT) as heterotopic noxious conditioning stimulation (HNCS). The subjective pain thresholds (Tp) and the RIII reflex threshold (Tr) were significantly lower in CTTH vs. controls. In controls a significant inhibition of the RIII reflex was observed during the CPT (-30%, P <0.05). Conversely, migraine and CTTH patients showed facilitation (+31%, P <0.05 and +40%, P <0.01, respectively) of the RIII reflex during the HNCS. This study demonstrates a dysfunction in systems subserving DNICs in both migraine and CTTH. Impairment of endogenous supraspinal pain modulation systems may contribute to the development and/or maintenance of central sensitization in primary headaches.
KW - Cold pressor test
KW - Headache
KW - Nociceptive flexion reflex
KW - Pain modulating systems
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U2 - 10.1111/j.1468-2982.2006.01130.x
DO - 10.1111/j.1468-2982.2006.01130.x
M3 - Article
C2 - 16776692
AN - SCOPUS:33745063622
VL - 26
SP - 782
EP - 789
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
IS - 7
ER -