Abnormal MRI signal in the rigid form of Huntington's disease

M. Savoiardo, L. Strada, D. Oliva, F. Girotti, L. D'Incerti

Research output: Contribution to journalArticlepeer-review


Eighteen patients with Huntington's disease (HD) were examined with MRI. Eleven had the common hyperkinetic form, seven had the rigid variant. All seven patients with rigid HD had increased signal intensity in the neostriatum in intermediate and T2-weighted images. Only one hyperkinetic HD had similar findings. In all the other cases, signal abnormalities were questionable or absent. Histological differences that account for differences in signal intensity may therefore lie in the caudate nucleus and putamen. Age of onset may be important, since the rigid patients were younger. Follow up studies may help in understanding these signal differences.

Original languageEnglish
Pages (from-to)888-891
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number10
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology


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