Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex

Luigi D'Argenzio, Giacomo Koch, Roberta Bombardieri, Francesco Mori, Romina Moavero, Diego Centonze, Paolo Curatolo

Research output: Contribution to journalArticle

Abstract

Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype.

Original languageEnglish
Pages (from-to)102-105
Number of pages4
JournalEpilepsy Research
Volume87
Issue number1
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Functional cortical connectivity
  • Transcranial Magnetic Stimulation
  • Tuberous Sclerosis Complex

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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