Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex

Luigi D'Argenzio; Giacomo Koch; Roberta Bombardieri; Francesco Mori; Romina Moavero; Diego Centonze; Paolo Curatolo

doi:10.1016/j.eplepsyres.2009.07.009

Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex

Luigi D'Argenzio, Giacomo Koch, Roberta Bombardieri, Francesco Mori, Romina Moavero, Diego Centonze, Paolo Curatolo

Research output: Contribution to journal › Article

Abstract

Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype.

Original language	English
Pages (from-to)	102-105
Number of pages	4
Journal	Epilepsy Research
Volume	87
Issue number	1
DOIs	https://doi.org/10.1016/j.eplepsyres.2009.07.009
Publication status	Published - Nov 2009

Keywords

Functional cortical connectivity
Transcranial Magnetic Stimulation
Tuberous Sclerosis Complex

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1016/j.eplepsyres.2009.07.009

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D'Argenzio, L., Koch, G., Bombardieri, R., Mori, F., Moavero, R., Centonze, D., & Curatolo, P. (2009). Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex. Epilepsy Research, 87(1), 102-105. https://doi.org/10.1016/j.eplepsyres.2009.07.009

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