TY - JOUR
T1 - Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex
AU - D'Argenzio, Luigi
AU - Koch, Giacomo
AU - Bombardieri, Roberta
AU - Mori, Francesco
AU - Moavero, Romina
AU - Centonze, Diego
AU - Curatolo, Paolo
PY - 2009/11
Y1 - 2009/11
N2 - Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype.
AB - Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype.
KW - Functional cortical connectivity
KW - Transcranial Magnetic Stimulation
KW - Tuberous Sclerosis Complex
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UR - http://www.scopus.com/inward/citedby.url?scp=70350426612&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2009.07.009
DO - 10.1016/j.eplepsyres.2009.07.009
M3 - Article
C2 - 19713078
AN - SCOPUS:70350426612
VL - 87
SP - 102
EP - 105
JO - Epilepsy Research
JF - Epilepsy Research
SN - 0920-1211
IS - 1
ER -