To investigate energy metabolism in migraine, we determined platelet mitochondrial enzyme activities in 40 patients with migraine with aura and in 40 patients with migraine without aura during attack-free intervals and in 24 healthy control subjects. NADH-dehydrogenase, citrate synthase and cytochrome-c-oxidase activities in both patient groups were significantly lower than in controls (p <0.01), while NADH-cytochrome-c-reductase activity was reduced only in migraine with aura (p <0.01). No alteration in succinate-dehydrogenase was observed. Monoamine-oxidase activity differed between sexes (p <0.05) but within each sex group no difference was observed between patients and controls. We hypothesize that the defect in mitochondrial enzymes observed indicates a systemic impairment of mitochondrial function in migraine patients.
|Number of pages||3|
|Publication status||Published - 1994|
ASJC Scopus subject areas
- Clinical Neurology