Abnormal pressure passive dilatation of cerebral arterioles in the elderly with isolated systolic hypertension

Sergio Castellani; Marzia Bacci; Andrea Ungar; Patrizio Prati; Claudia Di Serio; Pierangelo Geppetti; Giulio Masotti; Gian Gastone Neri Serneri; Gian Franco Gensini

doi:10.1161/01.HYP.0000248533.58693.c4

Abnormal pressure passive dilatation of cerebral arterioles in the elderly with isolated systolic hypertension

Sergio Castellani, Marzia Bacci, Andrea Ungar, Patrizio Prati, Claudia Di Serio, Pierangelo Geppetti, Giulio Masotti, Gian Gastone Neri Serneri, Gian Franco Gensini

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was to investigate the cerebrovascular adaptability to 2 sequential pressor stimuli in elderly patients with isolated systolic hypertension. Ten healthy elderly normotensive subjects (68 to 82 years), 10 elderly subjects with isolated systolic hypertension (63 to 82 years), and 10 young normotensive subjects (24 to 40 years) took part in the study. A pressor reaction, using sequential cold pressor and handgrip stimulation, was induced. The cerebrovascular response to the pressor stimulation was measured by transcranial Doppler determination of the mean flow velocity in the middle cerebral arteries. In all of the subjects, blood pressure increased during handgrip (+12 mm Hg, P

Original language	English
Pages (from-to)	1143-1150
Number of pages	8
Journal	Hypertension
Volume	48
Issue number	6
DOIs	https://doi.org/10.1161/01.HYP.0000248533.58693.c4
Publication status	Published - Dec 2006

Keywords

Adrenergic stimulation
Cerebrovascular adaptability
Isolated systolic hypertension

ASJC Scopus subject areas

Internal Medicine

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10.1161/01.HYP.0000248533.58693.c4

Cite this

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title = "Abnormal pressure passive dilatation of cerebral arterioles in the elderly with isolated systolic hypertension",

abstract = "The aim of this study was to investigate the cerebrovascular adaptability to 2 sequential pressor stimuli in elderly patients with isolated systolic hypertension. Ten healthy elderly normotensive subjects (68 to 82 years), 10 elderly subjects with isolated systolic hypertension (63 to 82 years), and 10 young normotensive subjects (24 to 40 years) took part in the study. A pressor reaction, using sequential cold pressor and handgrip stimulation, was induced. The cerebrovascular response to the pressor stimulation was measured by transcranial Doppler determination of the mean flow velocity in the middle cerebral arteries. In all of the subjects, blood pressure increased during handgrip (+12 mm Hg, P",

keywords = "Adrenergic stimulation, Cerebrovascular adaptability, Isolated systolic hypertension",

author = "Sergio Castellani and Marzia Bacci and Andrea Ungar and Patrizio Prati and {Di Serio}, Claudia and Pierangelo Geppetti and Giulio Masotti and Serneri, {Gian Gastone Neri} and Gensini, {Gian Franco}",

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T1 - Abnormal pressure passive dilatation of cerebral arterioles in the elderly with isolated systolic hypertension

AU - Castellani, Sergio

AU - Bacci, Marzia

AU - Ungar, Andrea

AU - Prati, Patrizio

AU - Di Serio, Claudia

AU - Geppetti, Pierangelo

AU - Masotti, Giulio

AU - Serneri, Gian Gastone Neri

AU - Gensini, Gian Franco

PY - 2006/12

Y1 - 2006/12

N2 - The aim of this study was to investigate the cerebrovascular adaptability to 2 sequential pressor stimuli in elderly patients with isolated systolic hypertension. Ten healthy elderly normotensive subjects (68 to 82 years), 10 elderly subjects with isolated systolic hypertension (63 to 82 years), and 10 young normotensive subjects (24 to 40 years) took part in the study. A pressor reaction, using sequential cold pressor and handgrip stimulation, was induced. The cerebrovascular response to the pressor stimulation was measured by transcranial Doppler determination of the mean flow velocity in the middle cerebral arteries. In all of the subjects, blood pressure increased during handgrip (+12 mm Hg, P

AB - The aim of this study was to investigate the cerebrovascular adaptability to 2 sequential pressor stimuli in elderly patients with isolated systolic hypertension. Ten healthy elderly normotensive subjects (68 to 82 years), 10 elderly subjects with isolated systolic hypertension (63 to 82 years), and 10 young normotensive subjects (24 to 40 years) took part in the study. A pressor reaction, using sequential cold pressor and handgrip stimulation, was induced. The cerebrovascular response to the pressor stimulation was measured by transcranial Doppler determination of the mean flow velocity in the middle cerebral arteries. In all of the subjects, blood pressure increased during handgrip (+12 mm Hg, P

KW - Adrenergic stimulation

KW - Cerebrovascular adaptability

KW - Isolated systolic hypertension

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Abnormal pressure passive dilatation of cerebral arterioles in the elderly with isolated systolic hypertension

Abstract

Keywords

ASJC Scopus subject areas

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