Abnormal pressure passive dilatation of cerebral arterioles in the elderly with isolated systolic hypertension

Sergio Castellani, Marzia Bacci, Andrea Ungar, Patrizio Prati, Claudia Di Serio, Pierangelo Geppetti, Giulio Masotti, Gian Gastone Neri Serneri, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to investigate the cerebrovascular adaptability to 2 sequential pressor stimuli in elderly patients with isolated systolic hypertension. Ten healthy elderly normotensive subjects (68 to 82 years), 10 elderly subjects with isolated systolic hypertension (63 to 82 years), and 10 young normotensive subjects (24 to 40 years) took part in the study. A pressor reaction, using sequential cold pressor and handgrip stimulation, was induced. The cerebrovascular response to the pressor stimulation was measured by transcranial Doppler determination of the mean flow velocity in the middle cerebral arteries. In all of the subjects, blood pressure increased during handgrip (+12 mm Hg, P

Original languageEnglish
Pages (from-to)1143-1150
Number of pages8
JournalHypertension
Volume48
Issue number6
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Adrenergic stimulation
  • Cerebrovascular adaptability
  • Isolated systolic hypertension

ASJC Scopus subject areas

  • Internal Medicine

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