Abnormal response to mental stress in patients with Takotsubo cardiomyopathy detected by gated single photon emission computed tomography

Roberto Sciagrà, Guido Parodi, Stefano Del Pace, Sabrina Genovese, Linda Zampini, Benedetta Bellandi, Gian Franco Gensini, Alberto Pupi, David Antoniucci

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Persistent abnormalities are usually not detected in patients with Takotsubo cardiomyopathy (TTC). Since sympathetically mediated myocardial damage has been proposed as a causative mechanism of TTC, we explored whether mental stress could evoke abnormalities in these patients. Methods: One month after an acute event, 22 patients fulfilling all TTC diagnostic criteria and 11 controls underwent resting and mental stress gated single photon emission computed tomography (SPECT). Perfusion, wall motion, transient ischaemic dilation (TID) and left ventricular (LV) ejection fraction (EF) were evaluated. Results: None of the controls showed stress-induced abnormalities. Mental stress evoked regional changes (perfusion defects and/or wall motion abnormality) in 16 TTC subjects and global abnormalities (LVEF fall >5% and/or TID >1.10) in 13; 3 had a completely negative response. TID, delta LVEF and delta wall motion score were significantly different in TTC vs control patients: 1.08∈±∈0.20 vs 0.95∈±∈0.11 (p∈

Original languageEnglish
Pages (from-to)765-772
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume37
Issue number4
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Gated single photon emission computed tomography
  • Mental stress
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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