TY - JOUR
T1 - Abnormal response to mental stress in patients with Takotsubo cardiomyopathy detected by gated single photon emission computed tomography
AU - Sciagrà, Roberto
AU - Parodi, Guido
AU - Del Pace, Stefano
AU - Genovese, Sabrina
AU - Zampini, Linda
AU - Bellandi, Benedetta
AU - Gensini, Gian Franco
AU - Pupi, Alberto
AU - Antoniucci, David
PY - 2010/4
Y1 - 2010/4
N2 - Purpose: Persistent abnormalities are usually not detected in patients with Takotsubo cardiomyopathy (TTC). Since sympathetically mediated myocardial damage has been proposed as a causative mechanism of TTC, we explored whether mental stress could evoke abnormalities in these patients. Methods: One month after an acute event, 22 patients fulfilling all TTC diagnostic criteria and 11 controls underwent resting and mental stress gated single photon emission computed tomography (SPECT). Perfusion, wall motion, transient ischaemic dilation (TID) and left ventricular (LV) ejection fraction (EF) were evaluated. Results: None of the controls showed stress-induced abnormalities. Mental stress evoked regional changes (perfusion defects and/or wall motion abnormality) in 16 TTC subjects and global abnormalities (LVEF fall >5% and/or TID >1.10) in 13; 3 had a completely negative response. TID, delta LVEF and delta wall motion score were significantly different in TTC vs control patients: 1.08∈±∈0.20 vs 0.95∈±∈0.11 (p∈
AB - Purpose: Persistent abnormalities are usually not detected in patients with Takotsubo cardiomyopathy (TTC). Since sympathetically mediated myocardial damage has been proposed as a causative mechanism of TTC, we explored whether mental stress could evoke abnormalities in these patients. Methods: One month after an acute event, 22 patients fulfilling all TTC diagnostic criteria and 11 controls underwent resting and mental stress gated single photon emission computed tomography (SPECT). Perfusion, wall motion, transient ischaemic dilation (TID) and left ventricular (LV) ejection fraction (EF) were evaluated. Results: None of the controls showed stress-induced abnormalities. Mental stress evoked regional changes (perfusion defects and/or wall motion abnormality) in 16 TTC subjects and global abnormalities (LVEF fall >5% and/or TID >1.10) in 13; 3 had a completely negative response. TID, delta LVEF and delta wall motion score were significantly different in TTC vs control patients: 1.08∈±∈0.20 vs 0.95∈±∈0.11 (p∈
KW - Gated single photon emission computed tomography
KW - Mental stress
KW - Takotsubo cardiomyopathy
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U2 - 10.1007/s00259-009-1362-z
DO - 10.1007/s00259-009-1362-z
M3 - Article
C2 - 20107787
AN - SCOPUS:77952093364
VL - 37
SP - 765
EP - 772
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 4
ER -