Abnormal responses to succinylcholine and pancuronium in a patient with hemiparesis

F. Fiacchino, C. Ariano, M. Gemma, D. Cerrato

Research output: Contribution to journalArticle

Abstract

Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of "new" junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of "decentralized" muscles should also be considered.

Original languageEnglish
Pages (from-to)497-499
Number of pages3
JournalItalian Journal of Neurological Sciences
Volume11
Issue number5
DOIs
Publication statusPublished - Oct 1990

Fingerprint

Pancuronium
Succinylcholine
Paresis
Curare
Muscles
Myasthenia Gravis
Motor Neurons
Cholinergic Receptors
Acetylcholinesterase
Antibodies
Neoplasms

Keywords

  • Hemiparesis
  • junctional acetylcholine receptors
  • muscle relaxants

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Abnormal responses to succinylcholine and pancuronium in a patient with hemiparesis. / Fiacchino, F.; Ariano, C.; Gemma, M.; Cerrato, D.

In: Italian Journal of Neurological Sciences, Vol. 11, No. 5, 10.1990, p. 497-499.

Research output: Contribution to journalArticle

@article{8b8cdc049dab4af085da19d45719d702,
title = "Abnormal responses to succinylcholine and pancuronium in a patient with hemiparesis",
abstract = "Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of {"}new{"} junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of {"}decentralized{"} muscles should also be considered.",
keywords = "Hemiparesis, junctional acetylcholine receptors, muscle relaxants",
author = "F. Fiacchino and C. Ariano and M. Gemma and D. Cerrato",
year = "1990",
month = "10",
doi = "10.1007/BF02336571",
language = "English",
volume = "11",
pages = "497--499",
journal = "Italian Journal of Neurological Sciences",
issn = "0392-0461",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Abnormal responses to succinylcholine and pancuronium in a patient with hemiparesis

AU - Fiacchino, F.

AU - Ariano, C.

AU - Gemma, M.

AU - Cerrato, D.

PY - 1990/10

Y1 - 1990/10

N2 - Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of "new" junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of "decentralized" muscles should also be considered.

AB - Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of "new" junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of "decentralized" muscles should also be considered.

KW - Hemiparesis

KW - junctional acetylcholine receptors

KW - muscle relaxants

UR - http://www.scopus.com/inward/record.url?scp=0025202678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025202678&partnerID=8YFLogxK

U2 - 10.1007/BF02336571

DO - 10.1007/BF02336571

M3 - Article

C2 - 2272786

AN - SCOPUS:0025202678

VL - 11

SP - 497

EP - 499

JO - Italian Journal of Neurological Sciences

JF - Italian Journal of Neurological Sciences

SN - 0392-0461

IS - 5

ER -