Abnormal responses to succinylcholine and pancuronium in a patient with hemiparesis

F. Fiacchino; C. Ariano; M. Gemma; D. Cerrato

doi:10.1007/BF02336571

Abnormal responses to succinylcholine and pancuronium in a patient with hemiparesis

F. Fiacchino, C. Ariano, M. Gemma, D. Cerrato

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of "new" junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of "decentralized" muscles should also be considered.

Original language	English
Pages (from-to)	497-499
Number of pages	3
Journal	Italian Journal of Neurological Sciences
Volume	11
Issue number	5
DOIs	https://doi.org/10.1007/BF02336571
Publication status	Published - Oct 1990

Keywords

Hemiparesis
junctional acetylcholine receptors
muscle relaxants

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1007/BF02336571

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abstract = "Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of {"}new{"} junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of {"}decentralized{"} muscles should also be considered.",

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AU - Ariano, C.

AU - Gemma, M.

AU - Cerrato, D.

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AB - Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of "new" junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of "decentralized" muscles should also be considered.

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