Abnormal responses to succinylcholine and pancuronium in a patient with hemiparesis

F. Fiacchino, C. Ariano, M. Gemma, D. Cerrato

Research output: Contribution to journalArticlepeer-review

Abstract

Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of "new" junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of "decentralized" muscles should also be considered.

Original languageEnglish
Pages (from-to)497-499
Number of pages3
JournalItalian Journal of Neurological Sciences
Volume11
Issue number5
DOIs
Publication statusPublished - Oct 1990

Keywords

  • Hemiparesis
  • junctional acetylcholine receptors
  • muscle relaxants

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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