Abstract
Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of "new" junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of "decentralized" muscles should also be considered.
| Original language | English |
|---|---|
| Pages (from-to) | 497-499 |
| Number of pages | 3 |
| Journal | Italian Journal of Neurological Sciences |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1990 |
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Keywords
- Hemiparesis
- junctional acetylcholine receptors
- muscle relaxants
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Abnormal responses to succinylcholine and pancuronium in a patient with hemiparesis. / Fiacchino, F.; Ariano, C.; Gemma, M.; Cerrato, D.
In: Italian Journal of Neurological Sciences, Vol. 11, No. 5, 10.1990, p. 497-499.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Abnormal responses to succinylcholine and pancuronium in a patient with hemiparesis
AU - Fiacchino, F.
AU - Ariano, C.
AU - Gemma, M.
AU - Cerrato, D.
PY - 1990/10
Y1 - 1990/10
N2 - Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of "new" junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of "decentralized" muscles should also be considered.
AB - Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of "new" junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of "decentralized" muscles should also be considered.
KW - Hemiparesis
KW - junctional acetylcholine receptors
KW - muscle relaxants
UR - http://www.scopus.com/inward/record.url?scp=0025202678&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025202678&partnerID=8YFLogxK
U2 - 10.1007/BF02336571
DO - 10.1007/BF02336571
M3 - Article
C2 - 2272786
AN - SCOPUS:0025202678
VL - 11
SP - 497
EP - 499
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 0392-0461
IS - 5
ER -