Abstract
Supersensitivity to depolarization produced by succinylcholine and resistance to pancuronium were observed in paretic muscles of a patient with a right frontoparietal tumor. The abnormal sensitivity to relaxants is compared with observations reported in patients with myasthenia gravis and hemiparesis. We hypothesize that upper motoneuron dysfunction may be followed by the appearance of "new" junctional receptors, which may occasion a supersensitivity to depolarization and a poor affinity for both curare and anti-acetylcholine-receptor antibodies. A decrease in acetylcholinesterase activity of "decentralized" muscles should also be considered.
Original language | English |
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Pages (from-to) | 497-499 |
Number of pages | 3 |
Journal | Italian Journal of Neurological Sciences |
Volume | 11 |
Issue number | 5 |
DOIs | |
Publication status | Published - Oct 1990 |
Keywords
- Hemiparesis
- junctional acetylcholine receptors
- muscle relaxants
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology