Abnormal sensorimotor integration is related to disease severity in Parkinson's disease: A TMS study

Stefano Tamburin; Antonio Fiaschi; Domenico Idone; Piergiorgio Lochner; Paolo Manganotti; Giampietro Zanette

doi:10.1002/mds.10515

Abnormal sensorimotor integration is related to disease severity in Parkinson's disease: A TMS study

Stefano Tamburin, Antonio Fiaschi, Domenico Idone, Piergiorgio Lochner, Paolo Manganotti, Giampietro Zanette

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms.

Original language	English
Pages (from-to)	1316-1324
Number of pages	9
Journal	Movement Disorders
Volume	18
Issue number	11
DOIs	https://doi.org/10.1002/mds.10515
Publication status	Published - Nov 2003

Keywords

Bradykinesia
Digital nerve stimulation
Motor evoked potentials
Parkinson's disease
Sensorimotor integration
Transcranial magnetic stimulation

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1002/mds.10515

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abstract = "Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms.",

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AU - Idone, Domenico

AU - Lochner, Piergiorgio

AU - Manganotti, Paolo

AU - Zanette, Giampietro

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AB - Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms.

KW - Bradykinesia

KW - Digital nerve stimulation

KW - Motor evoked potentials

KW - Parkinson's disease

KW - Sensorimotor integration

KW - Transcranial magnetic stimulation

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Abnormal sensorimotor integration is related to disease severity in Parkinson's disease: A TMS study

Abstract

Keywords

ASJC Scopus subject areas

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