Abnormal sensorimotor integration is related to disease severity in Parkinson's disease: A TMS study

Stefano Tamburin, Antonio Fiaschi, Domenico Idone, Piergiorgio Lochner, Paolo Manganotti, Giampietro Zanette

Research output: Contribution to journalArticlepeer-review

Abstract

Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms.

Original languageEnglish
Pages (from-to)1316-1324
Number of pages9
JournalMovement Disorders
Volume18
Issue number11
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Bradykinesia
  • Digital nerve stimulation
  • Motor evoked potentials
  • Parkinson's disease
  • Sensorimotor integration
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Abnormal sensorimotor integration is related to disease severity in Parkinson's disease: A TMS study'. Together they form a unique fingerprint.

Cite this