Abstract
Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms.
Original language | English |
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Pages (from-to) | 1316-1324 |
Number of pages | 9 |
Journal | Movement Disorders |
Volume | 18 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2003 |
Keywords
- Bradykinesia
- Digital nerve stimulation
- Motor evoked potentials
- Parkinson's disease
- Sensorimotor integration
- Transcranial magnetic stimulation
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)