Abnormal sensorimotor plasticity in migraine without aura patients

Francesco Pierelli, Elisa Iacovelli, Martina Bracaglia, Mariano Serrao, Gianluca Coppola

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The period between migraine attacks is characterized by paradoxical responses to repetitive sensory and transcranial magnetic stimulation (TMS). Abnormal long-term cortical functional plasticity may play a role and can be assessed experimentally by paired associative stimulation (PAS), in which somatosensory peripheral nerve stimuli are followed by TMS of the motor cortex. Changes in motor-evoked potential (MEP) amplitudes were recorded in 16 migraine without aura patients (MO) and 15 healthy volunteers (HV) before and after PAS, which consisted of 90 peripheral electrical right ulnar nerve stimulations and subsequent TMS pulses over the first dorsal interosseous (FDI) muscle activation site with a delay of 10 ms (excitability depressing) or 25 ms (excitability enhancing). As a control experiment of the 31 subjects studied, 8 (4 MO and 4 HV) also underwent PAS10 earlier, the recording of somatosensory high-frequency oscillations (HFOs) reflecting thalamocortical activation (early HFOs). Although PAS10 reduced MEP amplitudes in HV (-17.7%), it significantly increased amplitudes in MO (+35.9%). Although in HV MEP amplitudes were significantly potentiated (+55.1) after PAS25, only a slight, nonsignificant increase was observed in MO (+18.8%). In the control experiment, performed on 8 subjects pooled together, Pearson's correlation showed an inverse relationship between the percentage of MEP amplitude changes after PAS10 and early HFO amplitudes (r = -0.81; P =.01). Because we observed that the more deficient the long-term PAS-induced change, the more the thalamocortical activation decreased, we hypothesize that the abnormalities in long-term cortical plasticity observed in the interictal period between migraine episodes could be due to altered thalamic control.

Original languageEnglish
Pages (from-to)1738-1742
Number of pages5
JournalPain
Volume154
Issue number9
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Migraine without Aura
Motor Evoked Potentials
Transcranial Magnetic Stimulation
Healthy Volunteers
Migraine Disorders
Ulnar Nerve
Motor Cortex
Peripheral Nerves
Muscles

Keywords

  • High-frequency oscillations
  • Paired associative stimulation
  • Thalamocortical fibers
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Neurology
  • Pharmacology

Cite this

Pierelli, F., Iacovelli, E., Bracaglia, M., Serrao, M., & Coppola, G. (2013). Abnormal sensorimotor plasticity in migraine without aura patients. Pain, 154(9), 1738-1742. https://doi.org/10.1016/j.pain.2013.05.023

Abnormal sensorimotor plasticity in migraine without aura patients. / Pierelli, Francesco; Iacovelli, Elisa; Bracaglia, Martina; Serrao, Mariano; Coppola, Gianluca.

In: Pain, Vol. 154, No. 9, 09.2013, p. 1738-1742.

Research output: Contribution to journalArticle

Pierelli, F, Iacovelli, E, Bracaglia, M, Serrao, M & Coppola, G 2013, 'Abnormal sensorimotor plasticity in migraine without aura patients', Pain, vol. 154, no. 9, pp. 1738-1742. https://doi.org/10.1016/j.pain.2013.05.023
Pierelli, Francesco ; Iacovelli, Elisa ; Bracaglia, Martina ; Serrao, Mariano ; Coppola, Gianluca. / Abnormal sensorimotor plasticity in migraine without aura patients. In: Pain. 2013 ; Vol. 154, No. 9. pp. 1738-1742.
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