Abnormal sensory gating in patients with different types of focal dystonias

Antonella Conte, Daniele Belvisi, Maria Ilenia De Bartolo, Nicoletta Manzo, Francesca Natalia Cortese, Matteo Tartaglia, Gina Ferrazzano, Giovanni Fabbrini, Alfredo Berardelli

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Movement execution in healthy individuals increases the somatosensory temporal discrimination threshold. These changes are a result of mechanisms of sensory gating at the subcortical level. Although the somatosensory temporal discrimination threshold is abnormally increased in patients with focal dystonias, the effect of movement execution on somatosensory temporal discrimination in dystonic patients is unknown. Objectives: The objective of this study was to determine whether somatosensory temporal discrimination threshold modulation induced by voluntary movement is normal in different forms of focal dystonia. Methods: We enrolled 71 dystonic patients (24 with blepharospasm, 31 with cervical dystonia, and 16 with focal hand dystonia) and 39 age-matched healthy participants. Paired stimuli for the somatosensory temporal discrimination threshold were triggered by movement execution at movement onset and at various time intervals thereafter. We analyzed the kinematic features of the motor task to ascertain whether tactile input induces changes in movement parameters. Results: Movement execution led to greater and longer lasting increases in somatosensory temporal discrimination threshold values, both upon movement onset and at various time intervals thereafter, in patients with cervical dystonia and focal hand dystonia than in those with blepharospasm or the healthy participants. Somatosensory temporal discrimination testing did not induce any changes in the mean velocity of index finger movements in either patients or healthy participants. Conclusions: Somatosensory temporal discrimination threshold changes induced by movement execution are abnormal in focal dystonias. This abnormality is related to the type of dystonia. Abnormal gating of sensory information is likely involved in movement-induced triggering or worsening of different forms focal dystonia.

Original languageEnglish
Pages (from-to)1910-1917
Number of pages8
JournalMovement Disorders
Volume33
Issue number12
DOIs
Publication statusPublished - Dec 1 2018

Fingerprint

Sensory Gating
Dystonic Disorders
Blepharospasm
Torticollis
Healthy Volunteers
Dystonia
Dyskinesias
Touch
Biomechanical Phenomena
Fingers

Keywords

  • adult-onset focal dystonia
  • movement execution
  • proprioceptive input
  • sensorimotor integration
  • sensory gating
  • temporal discrimination

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Abnormal sensory gating in patients with different types of focal dystonias. / Conte, Antonella; Belvisi, Daniele; De Bartolo, Maria Ilenia; Manzo, Nicoletta; Cortese, Francesca Natalia; Tartaglia, Matteo; Ferrazzano, Gina; Fabbrini, Giovanni; Berardelli, Alfredo.

In: Movement Disorders, Vol. 33, No. 12, 01.12.2018, p. 1910-1917.

Research output: Contribution to journalArticle

Conte, Antonella ; Belvisi, Daniele ; De Bartolo, Maria Ilenia ; Manzo, Nicoletta ; Cortese, Francesca Natalia ; Tartaglia, Matteo ; Ferrazzano, Gina ; Fabbrini, Giovanni ; Berardelli, Alfredo. / Abnormal sensory gating in patients with different types of focal dystonias. In: Movement Disorders. 2018 ; Vol. 33, No. 12. pp. 1910-1917.
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abstract = "Background: Movement execution in healthy individuals increases the somatosensory temporal discrimination threshold. These changes are a result of mechanisms of sensory gating at the subcortical level. Although the somatosensory temporal discrimination threshold is abnormally increased in patients with focal dystonias, the effect of movement execution on somatosensory temporal discrimination in dystonic patients is unknown. Objectives: The objective of this study was to determine whether somatosensory temporal discrimination threshold modulation induced by voluntary movement is normal in different forms of focal dystonia. Methods: We enrolled 71 dystonic patients (24 with blepharospasm, 31 with cervical dystonia, and 16 with focal hand dystonia) and 39 age-matched healthy participants. Paired stimuli for the somatosensory temporal discrimination threshold were triggered by movement execution at movement onset and at various time intervals thereafter. We analyzed the kinematic features of the motor task to ascertain whether tactile input induces changes in movement parameters. Results: Movement execution led to greater and longer lasting increases in somatosensory temporal discrimination threshold values, both upon movement onset and at various time intervals thereafter, in patients with cervical dystonia and focal hand dystonia than in those with blepharospasm or the healthy participants. Somatosensory temporal discrimination testing did not induce any changes in the mean velocity of index finger movements in either patients or healthy participants. Conclusions: Somatosensory temporal discrimination threshold changes induced by movement execution are abnormal in focal dystonias. This abnormality is related to the type of dystonia. Abnormal gating of sensory information is likely involved in movement-induced triggering or worsening of different forms focal dystonia.",
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N2 - Background: Movement execution in healthy individuals increases the somatosensory temporal discrimination threshold. These changes are a result of mechanisms of sensory gating at the subcortical level. Although the somatosensory temporal discrimination threshold is abnormally increased in patients with focal dystonias, the effect of movement execution on somatosensory temporal discrimination in dystonic patients is unknown. Objectives: The objective of this study was to determine whether somatosensory temporal discrimination threshold modulation induced by voluntary movement is normal in different forms of focal dystonia. Methods: We enrolled 71 dystonic patients (24 with blepharospasm, 31 with cervical dystonia, and 16 with focal hand dystonia) and 39 age-matched healthy participants. Paired stimuli for the somatosensory temporal discrimination threshold were triggered by movement execution at movement onset and at various time intervals thereafter. We analyzed the kinematic features of the motor task to ascertain whether tactile input induces changes in movement parameters. Results: Movement execution led to greater and longer lasting increases in somatosensory temporal discrimination threshold values, both upon movement onset and at various time intervals thereafter, in patients with cervical dystonia and focal hand dystonia than in those with blepharospasm or the healthy participants. Somatosensory temporal discrimination testing did not induce any changes in the mean velocity of index finger movements in either patients or healthy participants. Conclusions: Somatosensory temporal discrimination threshold changes induced by movement execution are abnormal in focal dystonias. This abnormality is related to the type of dystonia. Abnormal gating of sensory information is likely involved in movement-induced triggering or worsening of different forms focal dystonia.

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