Abnormal somatotopic arrangement of sensorimotor interactions in dystonic patients

Stefano Tamburin, Paolo Manganotti, Carlo Alberto Marzi, Antonio Fiaschi, Giampietro Zanette

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The aim of the study was to detect abnormalities of sensorimotor interactions and their topographic distribution in the hand muscles of dystonic patients. We investigated the effect of electrical stimulation of the second (D2) and fifth (D5) fingers on the amplitude of motor evoked potentials (MEPs) in response to transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (TES) in the relaxed first dorsal interosseous (FDI) and abductor digiti minimi (ADM) muscles on both sides of eight patients with unilateral hand dystonia (HD) and in four patients with cervical dystonia (CD). Six Parkinson's disease patients were used as the disease control group and 10 healthy subjects served as normal controls. For each muscle, the digital stimulation was applied to a contiguous finger (CF) and to a non-contiguous finger (NCF). The digital stimulation was set at three times the sensory threshold and preceded TMS or TES at intervals ranging from 10 to 100 ms. In normal subjects, a somatotopic inhibitory effect was detected, since the CF stimulation was significantly more powerful in determining the reduction of MEPs in response to TMS at intervals ranging from 20 to 50 ms. In dystonic patients, on the contrary, the somatopic effect was not present, because both CF and NCF stimulation evoked a consistent MEP inhibition and no significant difference was detected between the conditioning effect of CF and NCF stimulation. These abnormalities were present in the muscles of both the affected and unaffected hands of HD patients, as well as in CD patients. TES conditioning provoked MEP inhibition only at interstimulus intervals (ISIs)

Original languageEnglish
Pages (from-to)2719-2730
Number of pages12
JournalBrain
Volume125
Issue number12
Publication statusPublished - Dec 1 2002

Fingerprint

Fingers
Motor Evoked Potentials
Transcranial Magnetic Stimulation
Hand
Torticollis
Muscles
Dystonia
Sensory Thresholds
Electric Stimulation
Parkinson Disease
Healthy Volunteers
Control Groups
Transcranial Direct Current Stimulation

Keywords

  • Digital nerve stimulation
  • Dystonia
  • Motor evoked potential
  • Sensorimotor integration
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tamburin, S., Manganotti, P., Marzi, C. A., Fiaschi, A., & Zanette, G. (2002). Abnormal somatotopic arrangement of sensorimotor interactions in dystonic patients. Brain, 125(12), 2719-2730.

Abnormal somatotopic arrangement of sensorimotor interactions in dystonic patients. / Tamburin, Stefano; Manganotti, Paolo; Marzi, Carlo Alberto; Fiaschi, Antonio; Zanette, Giampietro.

In: Brain, Vol. 125, No. 12, 01.12.2002, p. 2719-2730.

Research output: Contribution to journalArticle

Tamburin, S, Manganotti, P, Marzi, CA, Fiaschi, A & Zanette, G 2002, 'Abnormal somatotopic arrangement of sensorimotor interactions in dystonic patients', Brain, vol. 125, no. 12, pp. 2719-2730.
Tamburin S, Manganotti P, Marzi CA, Fiaschi A, Zanette G. Abnormal somatotopic arrangement of sensorimotor interactions in dystonic patients. Brain. 2002 Dec 1;125(12):2719-2730.
Tamburin, Stefano ; Manganotti, Paolo ; Marzi, Carlo Alberto ; Fiaschi, Antonio ; Zanette, Giampietro. / Abnormal somatotopic arrangement of sensorimotor interactions in dystonic patients. In: Brain. 2002 ; Vol. 125, No. 12. pp. 2719-2730.
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