Abnormal T2-STIR magnetic resonance in hypertrophic cardiomyopathy: A marker of advanced disease and electrical myocardial instability

Giancarlo Todiere, Lorena Pisciella, Andrea Barison, Annamaria Del Franco, Elisabetta Zachara, Paolo Piaggi, Federica Re, Alessandro Pingitore, Michele Emdin, Massimo Lombardi, Giovanni Donato Aquaro

Research output: Contribution to journalArticle

Abstract

Background: Myocardial hyperintensity on T2-weighted short-tau inversion recovery (STIR) (HyT2) cardiac magnetic resonance (CMR) images has been demonstrated in patients with hypertrophic cardiomyopathy (HCM) and is considered a sign of acute damage. The aim of the current study was to evaluate the relationship between HyT2 and both a) markers of ventricular electrical instability and b) clinical and CMR parameters.

Methods: Sixty-five patients underwent a thorough clinical examination, consisting of 24-h ECG recording and CMR examination including functional evaluation, T2-STIR images and late gadolinium enhancement (LGE).

Results: HyT2 was detected in 27 patients (42%), and subjects with HyT2 showed a greater left ventricle (LV) mass index (p<0.001), lower LV ejection fraction (p = 0.05) and greater extent of LGE (p

Conclusions: In HCM patients, HyT2 upon CMR examination is associated with more advanced disease and increased arrhythmic burden.

Original languageEnglish
Article numbere111366
JournalPLoS One
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 30 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Todiere, G., Pisciella, L., Barison, A., Del Franco, A., Zachara, E., Piaggi, P., Re, F., Pingitore, A., Emdin, M., Lombardi, M., & Aquaro, G. D. (2014). Abnormal T2-STIR magnetic resonance in hypertrophic cardiomyopathy: A marker of advanced disease and electrical myocardial instability. PLoS One, 9(10), [e111366]. https://doi.org/10.1371/journal.pone.0111366