Abnormal vasomotor function of the epicardial coronary arteries in children five to eight years after arterial switch operation

An angiographic and intracoronary Doppler flow wire study

Maria Giulia Gagliardi, Rachele Adorisio, Filippo Crea, Paolo Versacci, Roberto Di Donato, Stephen P. Sanders

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Abstract

OBJECTIVES: This study sought to test the vasoreactivity of the translocated coronary arteries after arterial switch operation (ASO) using quantitative angiographic analysis and intracoronary Doppler flow wire velocimetry. BACKGROUND: Late coronary artery events occur in 3% to 8% of patients after the ASO. Previous studies of coronary flow reserve have yielded disparate results. METHODS: Nineteen children previously underwent ASO (13 boys, age 5.4 ± 3.2 years, weight 22.3 ± 10.6 kg), and six control patients were enrolled in the study. Each patient underwent quantitative angiographic assessment of the epicardial coronary arteries before and after administration of nitroglycerin and coronary blood flow volume assessment before and after administration of adenosine and acetylcholine. The results were compared between groups. RESULTS: Epicardial coronary artery dilation in response to intracoronary nitroglycerin was significantly less in the ASO group than in the control group (left anterior descending [LAD], 5.0 ± 0.05% vs. 18.0 ± 4.5%, p = 0.0009; right coronary artery [RCA], 4.0 ± 0.07% vs. 32.7 ± 12.7%, p = 0.006). Moreover, the coronary blood flow volume reserve was reduced in ASO patients compared with control patients after intracoronary infusion of acetylcholine (2.3 ± 0.9 vs. 4.9 ± 1.7, p = 0.0003) or adenosine (2.7 ± 1.5 vs. 5 ± 0.5, p = 0.002). CONCLUSIONS: Epicardial coronary arteries fail to dilate normally in children after ASO, and the calculated coronary flow volume reserve is consequently reduced.

Original languageEnglish
Pages (from-to)1565-1572
Number of pages8
JournalJournal of the American College of Cardiology
Volume46
Issue number8
DOIs
Publication statusPublished - Oct 18 2005

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Coronary Vessels
Nitroglycerin
Blood Volume
Adenosine
Acetylcholine
Rheology
Arterial Switch Operation
Dilatation
Weights and Measures
Control Groups

ASJC Scopus subject areas

  • Nursing(all)

Cite this

@article{5a1f6969245a40e7874904bc39d4b742,
title = "Abnormal vasomotor function of the epicardial coronary arteries in children five to eight years after arterial switch operation: An angiographic and intracoronary Doppler flow wire study",
abstract = "OBJECTIVES: This study sought to test the vasoreactivity of the translocated coronary arteries after arterial switch operation (ASO) using quantitative angiographic analysis and intracoronary Doppler flow wire velocimetry. BACKGROUND: Late coronary artery events occur in 3{\%} to 8{\%} of patients after the ASO. Previous studies of coronary flow reserve have yielded disparate results. METHODS: Nineteen children previously underwent ASO (13 boys, age 5.4 ± 3.2 years, weight 22.3 ± 10.6 kg), and six control patients were enrolled in the study. Each patient underwent quantitative angiographic assessment of the epicardial coronary arteries before and after administration of nitroglycerin and coronary blood flow volume assessment before and after administration of adenosine and acetylcholine. The results were compared between groups. RESULTS: Epicardial coronary artery dilation in response to intracoronary nitroglycerin was significantly less in the ASO group than in the control group (left anterior descending [LAD], 5.0 ± 0.05{\%} vs. 18.0 ± 4.5{\%}, p = 0.0009; right coronary artery [RCA], 4.0 ± 0.07{\%} vs. 32.7 ± 12.7{\%}, p = 0.006). Moreover, the coronary blood flow volume reserve was reduced in ASO patients compared with control patients after intracoronary infusion of acetylcholine (2.3 ± 0.9 vs. 4.9 ± 1.7, p = 0.0003) or adenosine (2.7 ± 1.5 vs. 5 ± 0.5, p = 0.002). CONCLUSIONS: Epicardial coronary arteries fail to dilate normally in children after ASO, and the calculated coronary flow volume reserve is consequently reduced.",
author = "Gagliardi, {Maria Giulia} and Rachele Adorisio and Filippo Crea and Paolo Versacci and {Di Donato}, Roberto and Sanders, {Stephen P.}",
year = "2005",
month = "10",
day = "18",
doi = "10.1016/j.jacc.2005.06.065",
language = "English",
volume = "46",
pages = "1565--1572",
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}

TY - JOUR

T1 - Abnormal vasomotor function of the epicardial coronary arteries in children five to eight years after arterial switch operation

T2 - An angiographic and intracoronary Doppler flow wire study

AU - Gagliardi, Maria Giulia

AU - Adorisio, Rachele

AU - Crea, Filippo

AU - Versacci, Paolo

AU - Di Donato, Roberto

AU - Sanders, Stephen P.

PY - 2005/10/18

Y1 - 2005/10/18

N2 - OBJECTIVES: This study sought to test the vasoreactivity of the translocated coronary arteries after arterial switch operation (ASO) using quantitative angiographic analysis and intracoronary Doppler flow wire velocimetry. BACKGROUND: Late coronary artery events occur in 3% to 8% of patients after the ASO. Previous studies of coronary flow reserve have yielded disparate results. METHODS: Nineteen children previously underwent ASO (13 boys, age 5.4 ± 3.2 years, weight 22.3 ± 10.6 kg), and six control patients were enrolled in the study. Each patient underwent quantitative angiographic assessment of the epicardial coronary arteries before and after administration of nitroglycerin and coronary blood flow volume assessment before and after administration of adenosine and acetylcholine. The results were compared between groups. RESULTS: Epicardial coronary artery dilation in response to intracoronary nitroglycerin was significantly less in the ASO group than in the control group (left anterior descending [LAD], 5.0 ± 0.05% vs. 18.0 ± 4.5%, p = 0.0009; right coronary artery [RCA], 4.0 ± 0.07% vs. 32.7 ± 12.7%, p = 0.006). Moreover, the coronary blood flow volume reserve was reduced in ASO patients compared with control patients after intracoronary infusion of acetylcholine (2.3 ± 0.9 vs. 4.9 ± 1.7, p = 0.0003) or adenosine (2.7 ± 1.5 vs. 5 ± 0.5, p = 0.002). CONCLUSIONS: Epicardial coronary arteries fail to dilate normally in children after ASO, and the calculated coronary flow volume reserve is consequently reduced.

AB - OBJECTIVES: This study sought to test the vasoreactivity of the translocated coronary arteries after arterial switch operation (ASO) using quantitative angiographic analysis and intracoronary Doppler flow wire velocimetry. BACKGROUND: Late coronary artery events occur in 3% to 8% of patients after the ASO. Previous studies of coronary flow reserve have yielded disparate results. METHODS: Nineteen children previously underwent ASO (13 boys, age 5.4 ± 3.2 years, weight 22.3 ± 10.6 kg), and six control patients were enrolled in the study. Each patient underwent quantitative angiographic assessment of the epicardial coronary arteries before and after administration of nitroglycerin and coronary blood flow volume assessment before and after administration of adenosine and acetylcholine. The results were compared between groups. RESULTS: Epicardial coronary artery dilation in response to intracoronary nitroglycerin was significantly less in the ASO group than in the control group (left anterior descending [LAD], 5.0 ± 0.05% vs. 18.0 ± 4.5%, p = 0.0009; right coronary artery [RCA], 4.0 ± 0.07% vs. 32.7 ± 12.7%, p = 0.006). Moreover, the coronary blood flow volume reserve was reduced in ASO patients compared with control patients after intracoronary infusion of acetylcholine (2.3 ± 0.9 vs. 4.9 ± 1.7, p = 0.0003) or adenosine (2.7 ± 1.5 vs. 5 ± 0.5, p = 0.002). CONCLUSIONS: Epicardial coronary arteries fail to dilate normally in children after ASO, and the calculated coronary flow volume reserve is consequently reduced.

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U2 - 10.1016/j.jacc.2005.06.065

DO - 10.1016/j.jacc.2005.06.065

M3 - Article

VL - 46

SP - 1565

EP - 1572

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 8

ER -